A polymorphic indel containing the RS3 microsatellite in the 5′ flanking region of the vasopressin V1a receptor gene is associated with chimpanzee (Pan troglodytes) personality

Genes, Brain and Behavior

Volumn 11, Issue 5, 2012, Pages 552-558

  Hopkins, W D ^a,b   Donaldson, Z R ^c   Young, L J ^d  

^a GEORGIA STATE UNIVERSITY   (United States)

^b EMORY UNIVERSITY   (United States)

^c New York Presbyterian Morgan Stanley Children's Hospital   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Behavior; Chimpanzee; Dominance; Personality; Vasopressin

Indexed keywords

VASOPRESSIN; VASOPRESSIN V1A RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; COGNITION; DNA FLANKING REGION; FEMALE; GENE; GENE FREQUENCY; INDEL MUTATION; MALE; NONHUMAN; PAN TROGLODYTES; PRIORITY JOURNAL; PROMOTER REGION; RS3 GENE; SEX DIFFERENCE; SOCIAL INTERACTION;

5' FLANKING REGION; ALLELES; ANIMALS; FEMALE; GENE FREQUENCY; MALE; MICROSATELLITE REPEATS; PAN TROGLODYTES; PERSONALITY; POLYMORPHISM, GENETIC; RECEPTORS, VASOPRESSIN; SEX CHARACTERISTICS; SOCIAL BEHAVIOR;

MAMMALIA; MURIDAE; PAN; PAN TROGLODYTES;

EID: 84863206927     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2012.00799.x     Document Type: Article

References (38)

1. Avinum, R., Israel, S., Shalev, I., Gritsenko, I., Bornstein, G., Ebstein, R.P. & Knafo, A. (2011) AVPR1A variant associated with preschoolers' lower altruistic behavior. PLoS ONE 6, E25274.
2. Babb, P.L., Fernandez-Duque, E. & Schurr, T.G. (2010) AVPR1A sequence variation in monogomous owl monkeys (Aotus azarai) and its implications for the evolution of platyrrhine social behavior. J Mol Evol 71, 279-297.
3. Bachner-Melman, R., Dina, C., Zohar, A.H., Constantini, N., Lerer, E., Hoch, S., Sella, S., Nemanov, L., Gritsenko, I., Lichtenberg, P., Granot, R. & Ebstein, R.P. (2005) AVPR1a and SLC6A4 gene polymorphisms are associated with creative dance performance. Plos Genet 1, e42.
4. Consortium, T.C.S.a.A. (2005) Initial sequence of the chimpanzee genome and comparison with the human genome. Nature 437, 69-87.
5. De Vries, G.J., Crenshaw, B.D. & Al-Shamma, H.A. (1992) Oxytocin in maternal, sexual and social behaviors: Gonadal steroid modulation of vasopresson pathways. Ann N Y Acad Sci 652, 387-396.
6. Digman, J.M. (1990) Personality structure: Emergence of the five factor model. Annu Rev Psychol 41, 417-440.
7. Donaldson, Z.R. & Young, L.J. (2008) Oxytocin, vasopressin and the neurogenetics of sociality. Science 322, 900-904.
8. Donaldson, Z.R., Bai, Y., Kondrashov, F.A., Stoinski, T.L., Hammock, E.A.D. & Young, L.J. (2008) Evolution of a behavior-linked microsatellite-containing element of the 5' flanking region of the primate AVPR1A gene. BMC Evol Biol 8, 180-188.
9. Ebstein, R.P. (2006) The molecular genetic architecture of human personality: beyond self-report questionnaires. Mol Psychiatry 11, 427-445.
10. Foster, M.W., Gilby, I.C., Murray, C.M., Johnson, A., Wroblewski, E.E. & Pusey, A.E. (2009) Alpha male grooming patterns: implications for dominance "style". Am J Primatol 71, 136-144.
11. Freeman, H.D. & Gosling, S.D. (2010) Personality in nonhuman primates: a review and evaluation of past research. Am J Primatol 72, 653-671.
12. Goodson, J.L. & Bass, A.H. (2001) Social behavior functions and related anatomical characteristics of vasotocin/vasopressin systems in vertebrates. Brain Res Rev 35, 246-265.
13. Gosling, S.D. (2001) From mice to men: what can we learn about personality from animal research? Psychol Bull 127, 45-86.
14. Hammock, E.A. & Young, L.Y. (2004) Functional microsatellite polymorphisms associated with divergent social structure in vole species. Mol Biol Evol 21, 1057-1063.
15. Hammock, E.A. & Young, L.J. (2005) Micosatellite instability generates diversity in brain and sociobehavioral traits. Science 308, 1630-1634.
16. Hammock, E.A. & Young, L.J. (2006) Oxytocin, vasopressin and pair bonding: implications for autism. Philos Trans R Soc London B Biol Sci 361, 2187-2198.
17. Hammock, E.A., Lim, M.M., Nair, H.P. & Young, L.J. (2005) Association of vasopressin 1a receptor levels with a regulatory microsattelite and behavior. Genes Brain Behav 4, 289-301.
18. Hong, K.W., Weiss, A., Morimura, N., Udono, T., Hayasaka, I., Humle, T., Murayama, Y., Ito, S. & Uinoue-Murayama, M. (2011) Polymorphism of the tryptophan hydroxylase 2 (TPH2) gene is associated with chimpanzee neuroticism. PLoS ONE 6, e22144.
19. King, J.E. & Figueredo, A.J. (1997) The five-factor model plus dominance in chimpanzee personality. J Res Pers 31, 257-271.
20. King, J.E., Weiss, A. & Farmer, K.H. (2005) A chimpanzee (Pan troglodytes) analogue of cross-national generalization of personality structure: zoological parks and African sanctuary. J Pers 73, 389-410.
21. Knafo, A., Israel, S., Darvasi, A., Bachner0Melman, R., Uzefovsky, F., Cohen, L., Feldman, E., Lerer, E., Laiba, E., Raz, Y., Nemanov, L., Gritsenko, I., Dina, C., Agam, G., Dean, B., Bornstein, G. & Ebstein, R.P. (2008) Individual differences in allocation of funds in the Dictator Game and post-mortem hippocampal mRNA levels are correlated with length of the arginine vasopressin 1 a receptor (AVPR1A) RS3 promotor region repeat. Genes Brain Behav 7, 266-275.
22. Lim, M.M., Wang, Z., Olazabel, D.E., Ren, X., Terwillinger, E.F. & Young, L.J. (2004) Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene. Nature 429, 754-757.
23. Lim, M.M., Nair, H.P. & Young, L.J. (2005) Species and sex differences in brain distribution of CRF receptor subtypes 1 and 2 in monogomous and promiscuous vole species. J Comp Neurol 487, 75-92.
24. Melke, J. (2008) Autism: which genes are involved? Clin Neuropsychiatry 5, 63-69.
25. Meyer-Lindenberg, A., Kolachana, B.S., Gold, B., Olsh, A., Nicodemus, K.K., Mattay, V., Dean, M. & Weinberger, D.M. (2008) Genetic variants in AVPR1A linked to autism predict amygdala activation and personality traits in healthy humans. Mol Psychiatry 13, 968-975.
26. Meyer-Lindenberg, A., Domes, G., Kirsch, P. & Heinrichs, M. (2011) Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine. Nat Neurosci Rev 12, 524-538.
27. Prichard, Z.M., Mackinnon, A.J., Jorm, A.F. & Eastel, S. (2007) AVPR1A and OXTR polymorphisms are associated with sexual and reproductive behavioral phenotypes in humans. Hum Mutat 981, 1-6.
28. Pusey, A.E., Williams, J. & Goodall, J. (1997) The influence of dominance rank on the reproductive success of female chimpanzees. Science 277, 828-831.
29. Rosso, L., Keller, L., Kaessmann, H. & Hammond, R.L. (2008) Matng systems and avpr1a promoter variation in primates. Biol Lett 4, 375-378.
30. Tansey, K.E., Hill, M.J., Cochrane, L.E., Gill, M., Anney, R.J.L. & Gallagher, L. (2011) Functionality of promoter microsatellites of arginine vasopressin receptor 1A (AVPR1A): implications for autism. Mol Autism 2, 1-8.
31. Thompson, R.R., George, K., Walton, J.C., Orr, S.P. & Benson, J. (2006) Sex-specific influences of vasopressin on human social communication. Proc Natl Acad Sci 103, 7889-7894.
32. Ukkola-Vuoti, L., Oikkonen, J., Onkamo, P., Karma, K., Raijas, P. & Jarvela, I. (2011) Association of the argine vasopressin receptor 1A (AVPR1A) haplotypes with listening to music. J Hum Genet 56, 324-329.
33. Uzefovsky, F., Shalev, I., Israel, S., Knafo, A. & Ebstein, R.P. (2012) Vasopressin selectively impairs emotion recognition in men. Psychoneuroendocrinology 37, 576-580.
34. Walum, H., Westberg, L., Henningsson, S., Neiderhiser, J.M., Reiss, D., Igl, W., Ganiban, J.M., Spotts, E.L., Pedersen, N.L., Eriksson, E. & Lichenstein, P. (2008) Genetic variation in the vasopressin receptor 1a gene (AVPR1A) associates with pair bonding behavior in humans. Proc Natl Acad Sci 105, 14153-14156.
35. Weiss, A., King, J.E. & Hopkins, W.D. (2007) A cross-setting study of chimpanzee (Pan troglodytes) personality structure and development: zoological parks and Yerkes National Primate Research Center. Am J Primatol 69, 1264-1277.
36. Winslow, J.T., Hastings, N., Carter, C.S., Harbaugh, C.R. & Insel, T.R. (1993) The role of central vasopressin in pair bonding in monogamous praire voles. Nature 365, 545-548.
37. Wittig, R.M. & Boesch, C. (2003) Food competition and linear dominance hierarchy among female chimpanzees of the Tai National Park. Int J Primatol 24, 848-867.
38. Young, L.J. & Wang, Z. (2004) The neurobiology of pair bonding. Nat Neurosci Rev 7, 1048-1054.