Omega-3 fatty acids do not improve endothelial function in virologically suppressed HIV-infected men: A randomized placebo-controlled trial

AIDS Research and Human Retroviruses

Volumn 28, Issue 7, 2012, Pages 649-655

  Hileman, Corrilynn O ^a,b   Carman, Teresa L ^b,c   Storer, Norma J ^b,c   Labbato, Danielle E ^b,c   White, Cynthia A ^b,c   McComsey, Grace A ^b,c  

^a METROHEALTH MEDICAL CENTER   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPROTEIN; OMEGA 3 ACID ETHYL ESTER; PLACEBO;

ADULT; ARTICLE; CARDIOVASCULAR RISK; CELL ACTIVATION; CELL FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG ACTIVITY; DRUG EFFICACY; ENDOTHELIUM; ENDOTHELIUM CELL; FEMALE; GLUCOSE METABOLISM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFLAMMATION; INSULIN RESISTANCE; MALE; PATIENT COMPLIANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; ULTRASOUND;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANTI-HIV AGENTS; ARTERIOSCLEROSIS; BLOOD GLUCOSE; BRACHIAL ARTERY; CD4 LYMPHOCYTE COUNT; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; FATTY ACIDS, OMEGA-3; HUMANS; LIPOPROTEINS; MALE; MIDDLE AGED; TREATMENT OUTCOME; ULTRASONOGRAPHY, DOPPLER, COLOR;

EID: 84863196692     PISSN: 08892229     EISSN: 19318405     Source Type: Journal    
DOI: 10.1089/aid.2011.0088     Document Type: Article

References (37)

1. Sackoff JE, Hanna DB, Pfeiffer MR, and Torian LV: Causes of death among persons with AIDS in the era of highly active antiretroviral therapy: New York City. Ann Intern Med 2006;145(6):397-406. (Pubitemid 46768570)
2. Currier JS, Kendall MA, Zackin R, et al.: Carotid artery intima- media thickness and HIV infection: Traditional risk factors overshadow impact of protease inhibitor exposure. AIDS 2005;19(9):927-933. (Pubitemid 40834935)
3. Hsue PY, Lo JC, Franklin A, et al.: Progression of atherosclerosis as assessed by carotid intima-media thickness in patients with HIV infection. Circulation 2004;109(13):1603-1608. (Pubitemid 38451715)
4. El-Sadr WM, Lundgren JD, Neaton JD, et al.: CD4 + countguided interruption of antiretroviral treatment. N Engl J Med 2006;355(22):2283-2296. (Pubitemid 44837777)
5. Hsue PY, Hunt PW, Schnell A, et al.: Role of viral replication, antiretroviral therapy, and immunodeficiency in HIVassociated atherosclerosis. AIDS 2009;23(9):1059-1067.
6. Kuller LH, Tracy R, Belloso W, et al.: Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med 2008;5(10):e203.
7. Calmy A, Gayet-Ageron A, Montecucco F, et al.: HIV increases markers of cardiovascular risk: results from a randomized, treatment interruption trial. AIDS 2009;23(8): 929-939.
8. Triant VA, Meigs JB, and Grinspoon SK: Association of Creactive protein and HIV infection with acute myocardial infarction. J Acquir Immune Defic Syndr 2009;51(3):268-273.
9. Rissanen T, Voutilainen S, Nyyssonen K, Lakka TA, and Salonen JT: Fish oil-derived fatty acids, docosahexaenoic acid and docosapentaenoic acid, and the risk of acute coronary events: The Kuopio ischaemic heart disease risk factor study. Circulation 2000;102(22):2677-2679.
10. Kromhout D, Bosschieter EB, and de Lezenne Coulander C: The inverse relation between fish consumption and 20-year mortality from coronary heart disease. N Engl J Med 1985; 312(19):1205-1209. (Pubitemid 15009153)
11. Oomen CM, Feskens EJ, Rasanen L, et al.: Fish consumption and coronary heart disease mortality in Finland, Italy, and The Netherlands. Am J Epidemiol 2000;151(10):999-1006. (Pubitemid 30463579)
12. Bucher HC, Hengstler P, Schindler C, and Meier G: N-3 polyunsaturated fatty acids in coronary heart disease: A meta-analysis of randomized controlled trials. Am J Med 2002;112(4):298-304. (Pubitemid 34219443)
13. Weber C, Erl W, Pietsch A, Danesch U, and Weber PC: Docosahexaenoic acid selectively attenuates induction of vascular cell adhesion molecule-1 and subsequent monocytic cell adhesion to human endothelial cells stimulated by tumor necrosis factor-alpha. Arterioscler Thromb Vasc Biol 1995;15(5):622-628.
14. Mishra A, Chaudhary A, and Sethi S: Oxidized omega-3 fatty acids inhibit NF-kappaB activation via a PPARalphadependent pathway. Arterioscler Thromb Vasc Biol 2004; 24(9):1621-1627. (Pubitemid 39180885)
15. Mori TA, Woodman RJ, Burke V, Puddey IB, Croft KD, and Beilin LJ: Effect of eicosapentaenoic acid and docosahexaenoic acid on oxidative stress and inflammatory markers in treated-hypertensive type 2 diabetic subjects. Free Radic Biol Med 2003;35(7):772-781. (Pubitemid 37329480)
16. Mehra MR, Lavie CJ, Ventura HO, and Milani RV: Fish oils produce anti-inflammatory effects and improve body weight in severe heart failure. J Heart Lung Transplant 2006;25(7): 834-838. (Pubitemid 43963369)
17. De Caterina R and Libby P: Control of endothelial leukocyte adhesion molecules by fatty acids. Lipids 1996;31(Suppl): S57-63.
18. Lopez-Garcia E, Schulze MB, Manson JE, et al.: Consumption of (n-3) fatty acids is related to plasma biomarkers of inflammation and endothelial activation in women. J Nutr 2004;134(7):1806-1811. (Pubitemid 38886573)
19. Ross R: Atherosclerosis-an inflammatory disease. N Engl J Med 1999;340(2):115-126.
20. Melendez MM, McNurlan MA, Mynarcik DC, Khan S, and Gelato MC: Endothelial adhesion molecules are associated with inflammation in subjects with HIV disease. Clin Infect Dis 2008;46(5):775-780. (Pubitemid 351321565)
21. Ross AC, Armentrout R, ORiordan MA, et al.: Endothelial activation markers are linked to HIV status and are independent of antiretroviral therapy and lipoatrophy. J Acquir Immune Defic Syndr 2008;49(5):499-506.
22. Francisci D, Giannini S, Baldelli F, et al.: HIV type 1 infection, and not short-term HAART, induces endothelial dysfunction. AIDS 2009;23(5):589-596.
23. Corretti MC, Anderson TJ, Benjamin EJ, et al.: Guidelines for the ultrasound assessment of endothelial-dependent flowmediated vasodilation of the brachial artery: A report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 2002;39(2):257-265. (Pubitemid 34084631)
24. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, and Turner RC: Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28(7):412-419. (Pubitemid 15018832)
25. Morgan DR, Dixon LJ, Hanratty CG, et al.: Effects of dietary omega-3 fatty acid supplementation on endothelium-dependent vasodilation in patients with chronic heart failure. Am J Cardiol 2006;97(4):547-551. (Pubitemid 43190048)
26. Khan F, Elherik K, Bolton-Smith C, et al.: The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjects. Cardiovasc Res 2003; 59(4):955-962. (Pubitemid 38366251)
27. Shah AP, Ichiuji AM, Han JK, et al.: Cardiovascular and endothelial effects of fish oil supplementation in healthy volunteers. J Cardiovasc Pharmacol Ther 2007;12(3):213-219. (Pubitemid 47305434)
28. Hileman CO, Carman TL, Gripshover BM, et al.: Salsalate is poorly tolerated and fails to improve endothelial function in virologically suppressed HIV-infected adults. AIDS 31; 24(12):1958-1961.
29. Wohl DA, Tien HC, Busby M, et al.: Randomized study of the safety and efficacy of fish oil (omega-3 fatty acid) supplementation with dietary and exercise counseling for the treatment of antiretroviral therapy-associated hypertriglyceridemia. Clin Infect Dis 2005;41(10):1498-1504. (Pubitemid 41579995)
30. Woods MN, Wanke CA, Ling PR, et al.: Effect of a dietary intervention and n-3 fatty acid supplementation on measures of serum lipid and insulin sensitivity in persons with HIV. Am J Clin Nutr 2009;90(6):1566-1578.
31. Thusgaard M, Christensen JH, Morn B, et al.: Effect of fish oil (n-3 polyunsaturated fatty acids) on plasma lipids, lipoproteins and inflammatory markers in HIV-infected patients treated with antiretroviral therapy: A randomized, doubleblind, placebo-controlled study. Scand J Infect Dis 2009;41(10):760-766.
32. Carter VM, Woolley I, Jolley D, Nyulasi I, Mijch A, and Dart A: A randomised controlled trial of omega-3 fatty acid supplementation for the treatment of hypertriglyceridemia in HIV-infected males on highly active antiretroviral therapy. Sex Health 2006;3(4):287-290.
33. De Truchis P, Kirstetter M, Perier A, et al.: Reduction in triglyceride level with N-3 polyunsaturated fatty acids in HIV-infected patients taking potent antiretroviral therapy: A randomized prospective study. J Acquir Immune Defic Syndr 2007;44(3):278-285. (Pubitemid 46328343)
34. Gerber JG, Kitch DW, Fichtenbaum CJ, et al.: Fish oil and fenofibrate for the treatment of hypertriglyceridemia in HIV-infected subjects on antiretroviral therapy: Results of ACTG A5186. J Acquir Immune Defic Syndr 2008;47(4): 459-466. (Pubitemid 351366958)
35. Murphy RL, Berzins B, Zala C, et al.: Change to atazanavir/ ritonavir treatment improves lipids but not endothelial function in patients on stable antiretroviral therapy. AIDS 27;24(6):885-890.
36. Torriani FJ, Komarow L, Parker RA, et al.: Endothelial function in human immunodeficiency virus-infected antiretroviral- naive subjects before and after starting potent antiretroviral therapy: The ACTG (AIDS Clinical Trials Group) Study 5152s. J Am Coll Cardiol 2008;52(7):569-576.
37. Marchioli R, Barzi F, Bomba E, et al.: Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: Time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nellInfarto Miocardico (GISSI)-Prevenzione. Circulation 2002; 105(16):1897-1903. (Pubitemid 34437615)