Effects of ethyl acetate extract of Poncirus trifoliata fruit for glucocorticoid-induced osteoporosis

Biomolecules and Therapeutics

Volumn 20, Issue 1, 2012, Pages 89-95

  Yoon, Hyung Young ^a   Cho, Yun Seok ^b   Jin, Qinglong ^c   Kim, Hyun Gyu ^b   Woo, Eun Rhan ^c   Chung, Yoon Sok ^a  

^a Ajou University School of Medicine   (South Korea)

^b Hanlim Pharmaceuticals   (South Korea)

^c Chosun University   (South Korea)

Author keywords

Ethyl acetate extract; Glucocorticoid induced osteoporosis; Osteoblast; Osteoclast; Poncirus trifoliata fruit

Indexed keywords

ACETIC ACID ETHYL ESTER; ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ALKALINE PHOSPHATASE; AURANTIIN; DEXAMETHASONE; MESSENGER RNA; OSTEOPONTIN; OSTEOPROTEGERIN; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; PONCIRIN; PREDNISOLONE; STRONTIUM CHLORIDE; TRIFOLIATE ORANGE EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; CELL DIFFERENTIATION; CONTROLLED STUDY; CORTICOSTEROID INDUCED OSTEOPOROSIS; DRUG EFFECT; DRUG ISOLATION; DRUG STRUCTURE; ENZYME ACTIVITY; FRUIT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MOUSE; MULTINUCLEAR CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OSTEOBLAST; OSTEOCLAST; PROTEIN EXPRESSION; TRIFOLIATE ORANGE;

EID: 84863180570     PISSN: 19769148     EISSN: 20054483     Source Type: Journal    
DOI: 10.4062/biomolther.2012.20.1.089     Document Type: Article

References (39)

1. Audran, M. (2000) Raloxifene, selective estrogen receptor modulator (SERM). Introduction and conclusion. Joint. Bone. Spine. 67 Suppl 1, 3s-6s, 23s-25s.
2. Bensky, D., Clavey, S., and Stöger, E. (2004). Herbs that regulate the Qi, Chinese Herbal Medicine: Materia Medica. Eastland Press Inc., Seattle.
3. Boling, E. P. (2004) Secondary osteoporosis: underlying disease and the risk for glucocorticoid-induced osteoporosis. Clin. Ther. 26, 1-14.
4. Canalis, E. (1996) Clinical review 83: Mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis. J. Clin. Endocrinol. Metab. 81, 3441-3447.
5. Chen, T. L. (2004) Inhibition of growth and differentiation of osteoprogenitors in mouse bone marrow stromal cell cultures by increased donor age and glucocorticoid treatment. Bone. 35, 83-95.
6. Cho, E. J., Piao, X., Piao, L., Piao, H., Park, M. K., Kim, B. K. and Park J. H. (2000) Chemical constituents of the fruit of Citrus junos. Nat. Prod. Sci. 6, 179-182.
7. Ding, P., Tang, Q. and Chen, L. (2009) Effects of naringin on proliferation, differentiation and matrix mineralization of MC3T3-E1 cells. Zhongguo. Zhong. Yao. Za. Zhi. 34, 1712-1716.
8. Fazzalari, N. L. (2008) Bone remodeling: a review of the bone microenvironment perspective for fragility fracture (osteoporosis) of the hip. Semin. Cell. Dev. Biol. 19, 467-472.
9. Geusens, P. and Reid, D. (2005) Newer drug treatments: their effects on fracture prevention. Best. Pract. Res. Clin. Rheumatol. 19, 983-989.
10. Han, A. R., Kim, J. B., Lee, J., Nam, J. W., Lee, I. S., Shim, C. K., Lee, K. T. and Seo, E. K. (2007) A new flavanone glycoside from the dried immature fruits of Poncirus trifoliata. Chem. Pharm. Bull. (Tokyo). 55, 1270-1273.
11. Katagiri, H. (2006) Active vitamin D and vitamin K as therapeutic agents for osteoporosis. Nihon. Rinsho. 64, 1639-1643.
12. Kawaguchi, H., Manabe, N., Miyaura, C., Chikuda, H., Nakamura, K. and Kuro-o, M. (1999) Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopenia. J. Clin. Invest. 104, 229-237.
13. Khosla, S. (2001) Minireview: the OPG/RANKL/RANK system. Endocrinology. 142, 5050-5055.
14. Kim, D. H., Bae, E. A. and Han, M. J. (1999) Anti-Helicobacter pylori activity of the metabolites of poncirin from Poncirus trifoliata by human intestinal bacteria. Biol. Pharm. Bull. 22, 422-424.
15. Kim, H. J., Zhao, H., Kitaura, H., Bhattacharyya, S., Brewer, J. A., Muglia, L. J., Ross, F. P. and Teitelbaum, S. L. (2006) Glucocorticoids suppress bone formation via the osteoclast. J. Clin. Invest. 116, 2152-2160.
16. Kim, K. W., Suh, S. J., Lee, T. K., Ha, K. T., Kim, J. K., Kim, K. H., Kim, D. I., Jeon, J. H., Moon, T. C. and Kim, C. H. (2008) Effect of safflower seeds supplementation on stimulation of the proliferation, differentiation and mineralization of osteoblastic MC3T3-E1 cells. J. Ethnopharmacol. 115, 42-49.
17. Kim, B. Y., Yoon, H. Y., Yun, S. I., Woo, E. R., Song, N. K., Kim, H. G., Jeong, S. Y. and Chung, Y. S. (2011) In vitro and In vivo Inhibition of Glucocorticoid-induced Osteoporosis by the Hexane Extract of Poncirus trifoliata. Phytother. Res. 2011.
18. Kulenović, I., Rasić, S. and Kulenović, E. (2006) Osteoporosis: current trends in diagnosis and management. Bosn. J. Basic. Med. Sci. 6, 24-28.
19. Lane, N. E., Yao, W., Balooch, M., Nalla, R. K., Balooch, G., Habelitz, S., Kinney, J. H. and Bonewald, L. F. (2006) Glucocorticoid-treated mice have localized changes in trabecular bone material properties and osteocyte lacunar size that are not observed in placebo-treated or estrogen-deficient mice. J. Bone. Miner. Res. 21, 466-476.
20. Liu, J. C., Chan, P., Hsu, F. L., Chen, Y. J., Hsieh, M. H., Lo, M. Y. and Lin, J. Y. (2002) The in vitro inhibitory effects of crude extracts of traditional Chinese herbs on 3-hydroxy-3-methylglutaryl-coenzyme A reductase on Vero cells. Am. J. Chin. Med. 30, 629-636.
21. Malluche, H. H., Koszewski, N., Monier-Faugere, M. C., Williams, J. P. and Mawad, H. (2006) Influence of the parathyroid glands on bone metabolism. Eur. J. Clin. Invest. 36 Suppl 2, 23-33.
22. Manolagas, S. C. (2000) Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr. Rev. 21, 115-137.
23. Meunier, P. J. (2001) Anabolic agents for treating postmenopausal osteoporosis. Joint. Bone. Spine. 68, 576-581.
24. Mundy, G. R. (2001) Statins and their potential for osteoporosis. Bone. 29, 495-497.
25. Neuprez, A., Hiligsmann, M., Scholtissen, S., Bruyere, O. and Reginster, J. Y. (2008) Strontium ranelate: the first agent of a new therapeutic class in osteoporosis. Adv. Ther. 25, 1235-1256.
26. O'Brien, C. A., Jia, D., Plotkin, L. I., Bellido, T., Powers, C. C., Stewart, S. A., Manolagas, S. C. and Weinstein, R. S. (2004) Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength. Endocrinology. 145, 1835-1841.
27. Sato, M., Garsky, V., Majeska, R. J., Einhorn, T. A., Murray, J., Tashjian, A. H. Jr. and Gould, R. J. (1994) Structure-activity studies of the s-echistatin inhibition of bone resorption. J. Bone. Miner. Res. 9, 1441-1449.
28. Schäcke, H., Döcke, W. D. and Asadullah, K. (2002) Mechanisms involved in the side effects of glucocorticoids. Pharmacol. Ther. 96, 23-43.
29. Shin, T. Y., Oh, J. M., Choi, B. J., Park, W. H., Kim, C. H., Jun, C. D. and Kim, S. H. (2006) Anti-inflammatory effect of Poncirus trifoliate fruit through inhibition of NF-kappaB activation in mast cells. Toxicol. In. Vitro. 20, 1071-1076.
30. Stein, G. S., Lian, J. B., Stein, J. L., Van Wijnen, A. J. and Montecino, M. (1996) Transcriptional control of osteoblast growth and differentiation. Physiol. Rev. 76, 593-629.
31. Suh, S. J., Yun, W. S., Kim, K. S., Jin, U. H., Kim, J. K., Kim, M. S., Kwon, D. Y. and Kim, C. H. (2007) Stimulative effects of Ulmus davidiana Planch (Ulmaceae) on osteoblastic MC3T3-E1 cells. J. Ethnopharmacol. 109, 480-485.
32. Turner, C. H. (1991) Toward a cure for osteoporosis: reversal of excessive bone fragility. Osteoporos. Int. 2, 12-19.
33. Walsh, L. J., Wong, C. A., Pringle, M. and Tattersfield, A. E. (1996) Use of oral corticosteroids in the community and the prevention of secondary osteoporosis: a cross sectional study. BMJ. 313, 344-346.
34. Wei, M., Yang, Z., Li, P., Zhang, Y. and Sse, W. C. (2007) Anti-osteoporosis activity of naringin in the retinoic acid-induced osteoporosis model. Am. J. Chin. Med. 35, 663-667.
35. Weinstein, R. S., Chen, J. R., Powers, C. C., Stewart, S. A., Landes, R. D., Bellido, T., Jilka, R. L., Parfitt, A. M. and Manolagas, S. C. (2002) Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids. J. Clin. Invest. 109, 1041-1048.
36. Weinstein, R. S., Jilka, R. L., Parfitt, A. M. and Manolagas, S. C. (1998) Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J. Clin. Invest. 102, 274-282.
37. Yeung, H. C. (1985). An excellent Chinese herbal giving information on over 500 species. Rather technical and probably best suited to the more accomplished user of herbs. Handbook of Chinese Herbs and Formulas. Institute of Chinese Medicine, Los Angeles.
38. Yoon, H. Y., Yun, S. I., Kim, B. Y., Jin, Q., Woo, E. R., Jeong, S. Y. and Chung, Y. S. (2011) Poncirin promotes osteoblast differentiation but inhibits adipocyte differentiation in mesenchymal stem cells. Eur. J. Pharmacol. 664, 54-59.
39. Zhang, P., Dai, K. R., Yan, S. G., Yan, W. Q., Zhang, C., Chen, D. Q., Xu, B. and Xu, Z. W. (2009) Effects of naringin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cell. Eur. J. Pharmacol. 607, 1-5.