Poncirin promotes osteoblast differentiation but inhibits adipocyte differentiation in mesenchymal stem cells

European Journal of Pharmacology

Volumn 664, Issue 1-3, 2011, Pages 54-59

  Yoon, Hyung Young ^a   Yun, Sun Il ^a   Kim, Bo Young ^a   Jin, Qinglong ^b   Woo, Eun Rhan ^b   Jeong, Seon Yong ^a   Chung, Yoon Sok ^a  

^a Ajou University School of Medicine   (South Korea)

^b Chosun University   (South Korea)

Author keywords

Adipocyte; Differentiation; Mesenchymal stem cell; Osteoblast; Poncirin

Indexed keywords

ALKALINE PHOSPHATASE; CCAAT ENHANCER BINDING PROTEIN BETA; FLAVONOID GLYCOSIDE; MESSENGER RNA; OSTEOCALCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PORCININ; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; GENE EXPRESSION; LIPID STORAGE; MALE; MARKER GENE; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADIPOCYTES; ADIPOGENESIS; ANIMALS; BIOLOGICAL MARKERS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL LINE; CORE BINDING FACTOR ALPHA 1 SUBUNIT; FEMUR; FLAVONOIDS; GENE EXPRESSION REGULATION; MALE; MESENCHYMAL STEM CELLS; MICE; MINERALS; OSTEOBLASTS; TIBIA; TRANSCRIPTION, GENETIC;

EID: 79957886180     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.04.047     Document Type: Article

References (28)

1. Akune, T., Ohba, S., Kamekura, S., Yamaguchi, M., Chung, U.I., Kubota, N., Terauchi, Y., Harada, Y., Azuma, Y., Nakamura, K., Kadowaki, T., Kawaguchi, H., 2004. PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J. Clin. Invest. 113, 846-855.
2. Asakura, A., Komaki, M., Rudnicki, M., 2001. Muscle satellite cells are multipotential stem cells that exhibit myogenic, osteogenic, and adipogenic differentiation. Differentiation 68, 245-253. (Pubitemid 33754997)
3. Aubin, J.E., 1998. Bone stem cells. J. Cell. Biochem. Suppl. 30-31, 73-82.
4. Audran, M., 2006. Drug combination strategies for osteoporosis. Joint Bone Spine 73, 374-378.
5. Boskey, A.L., Maresca, M., Ullrich, W., Doty, S.B., Butler, W.T., Prince, C.W., 1993. Osteopontin-hydroxyapatite interactions in vitro: inhibition of hydroxyapatite formation and growth in a gelatin-gel. Bone Miner. 22, 147-159. (Pubitemid 23272798)
6. Chung, Y.S., Lee, M.D., Lee, S.K., Kim, H.M., Fitzpatrick, L.A., 2000. HMG-CoA reductase inhibitors increase BMD in type 2 diabetes mellitus patients. J. Clin. Endocrinol. Metab. 85, 1137-1142.
7. Collin, P., Nefussi, J.R., Wetterwald, A., Nicolas, V., Boy-Lefebvre, M.L., Fleisch, H., Forest, N., 1992. Expression of collagen, osteocalcin, and bone alkaline phosphatase in a mineralizing rat osteoblastic cell culture. Calcif. Tissue Int. 50, 175-183.
8. Dennis, J.E., Merriam, A., Awadallah, A., Yoo, J.U., Johnstone, B., Caplan, A.I., 1999. A quardripotential mesenchymal progenitor cell isolated from the marrow of an adult mouse. J. Bone Miner. Res. 14, 700-709.
9. Franceschi, R.T., Ge, C., Xiao, G., Roca, H., Jiang, D., 2007. Transcriptional regulation of osteoblasts. Ann. N.Y. Acad. Sci. 1116, 196-207.
10. Hong, J.H., Hwang, E.S., McManus, M.T., Amsterdam, A., Tian, Y., Kalmukova, R., Mueller, E., Benjamin, T., Spiegelman, B.M., Sharp, P.A., Hopkins, N., Yaffe, M.B., 2005. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 309, 1074-1078. (Pubitemid 41134465)
11. Hong, D., Chen, H.X., Xue, Y., Li, D.M., Wan, X.C., Ge, R., Li, J.C., 2009. Osteoblastogenic effects of dexamethasone through upregulation of TAZ expression in rat mesenchymal stem cells. J. Steroid Biochem. Mol. Biol. 116, 86-92.
12. Hunter, G.K., Hauschka, P.V., Poole, A.R., Rosenberg, L.C., Goldberg, H.A., 1996. Nucleation and inhibition of hydroxyapatite formation by mineralized tissue proteins. Biochem. J. 317, 59-64. (Pubitemid 26238329)
13. Jaiswal, N., Haynesworth, S.E., Caplan, A.I., Bruder, S.P., 1997. Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J. Cell. Biochem. 64, 295-312.
14. Kawaguchi, H., Manabe, N., Miyaura, C., Dhikuda, H., Nakamura, K., Kuro-o, M., 1999. Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopenia. J. Clin. Invest. 104, 229-237.
15. Kim, D.H., Bae, E.A., Han, M.J., 1999. Anti-helicobacter pylori activity of the metabolites of poncirin from Poncirus trifoliata by human intestinal bacteria. Biol. Pharm. Bull. 22, 422-424.
16. Lee, C.J., Lee, H.H., Seok, J.H., Hur, G.M., Park, Js., Bae, S., Lim, J.H., Park, Y.C., 2004. Effects of betaine, coumarin and flavonoids on mucin release from cultured hamster tracheal surface epithelial cells. Phytother. Res. 18, 301-305.
17. Lee, H.W., Suh, J.H., Kim, H.N., Kim, A.Y., Park, S.Y., Shin, C.S., Choi, J.Y., Kim, J.B., 2008. Berberine promotes osteoblast differentiation by Runx2 activation with p38 MAPK. J. Bone Miner. Res. 23, 1227-1237.
18. Lin, Y.F., Jing, W., Wu, L., Li, X.Y., Wu, Y., Liu, L., Tang, W., Long, J., Tian, W.D., Mo, X.M., 2008. Identification of osteo-adipo progenitor cells in fat tissue. Cell Prolif. 41, 803-812.
19. Liu, J.C., Chan, P., Hsu, F.L., Chen, Y.J., Hsieh, M.H., Lo, M.Y., Lin, J.Y., 2002. The in vitro inhibitory effects of crude extracts of traditional Chinese herbs on 3-hydroxy-3-methylglutaryl-coenzyme A reductase on Vero cells. Am. J. Chin. Med. 30, 629-636.
20. Meunier, P.J., 2001. Anabolic agents for treating postmenopausal osteoporosis. Joint Bone Spine 68, 576-581. (Pubitemid 34037294)
21. Mundy, G.R., 2001. Statins and their potential for osteoporosis. Bone 29, 495-497. (Pubitemid 33124289)
22. Pittenger, M.F., Mackay, A.M., Beck, S.C., Jaiswal, R.K., Douglas, R., Mosca, J.D., Moorman, M.A., Simonetti, D.W., Craig, S., Marshak, D.R., 1999. Multilineage potential of adult human mesenchymal stem cells. Science 284, 143-147. (Pubitemid 29282067)
23. Prusty, D., Park, B.H., Davis, K.E., Farmer, S.R., 2002. Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor gamma (PPAR-γ) and C/EBP alpha gene expression during the differentiation of 3T3-L1 preadipocytes. J. Biol. Chem. 277, 46226-46232.
24. Rittling, S.R., Matsumoto, H.N., McKee, M.D., Nanci, A., An, X.R., Novick, K.E., Kowalski, A. J., Noda, M., Denhardt, D.T., 1998. Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro. J. Bone Miner. Res. 13, 1101-1111.
25. Shin, T.Y., Oh, J.M., Choi, G.J., Park, W.H., Kim, C.H., Jun, C.D., Kim, S.H., 2006. Antiinflammatory effect of Poncirus trifoliata fruit though inhibition of NF-κB activation in mast cells. Toxicol. In Vitro 20, 1071-1076. (Pubitemid 44067375)
26. Turner, C.H., 1991. Toward a cure for osteoporosis: reversal of excessive bone fragility. Osteoporos. Int. 2, 12-19.
27. Xiao, G., Jiang, D., Gopalakrishnan, R., Franceschi, R.T., 2002. Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2. J. Biol. Chem. 277, 36181-36187.
28. Youn, W.G., Kim, D.H., Kim, N.J., Hong, N.D., 1992. Biological active components of fruits of Poncirus trifoliata. Yakhak Hoeji 36, 548-555.