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Volumn 56, Issue 3, 2012, Pages 1162-1169

Identification of a Cryptococcus neoformans cytochrome P450 lanosterol 14α-demethylase (Erg11) residue critical for differential susceptibility between fluconazole/voriconazole and itraconazole/posaconazole

Author keywords

[No Author keywords available]

Indexed keywords

FLUCONAZOLE; FUNGAL ENZYME; ITRACONAZOLE; PHENYLALANINE; POSACONAZOLE; STEROL 14ALPHA DEMETHYLASE; TYROSINE; VORICONAZOLE;

EID: 84863164890     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.05502-11     Document Type: Article
Times cited : (92)

References (30)
  • 2
    • 0037532708 scopus 로고    scopus 로고
    • Cryptococcus neoformans var. neoformans resistant to fluconazole in an HIV-negative patient with chronic lymphocytic leukemia
    • DOI 10.1046/j.1469-0691.2003.00571.x
    • Assing K, Birgens H, Arendrup M. 2003. Cryptococcus neoformans var neoformans resistant to fluconazole in an HIV-negative patient with chronic lymphocytic leukemia. Clin. Microbiol. Infect. 9:441-444. (Pubitemid 36758137)
    • (2003) Clinical Microbiology and Infection , vol.9 , Issue.5 , pp. 441-444
    • Assing, K.1    Birgens, H.2    Arendrup, M.3
  • 3
    • 0031913283 scopus 로고    scopus 로고
    • The hidden danger of primary fluconazole prophylaxis for patients with AIDS
    • Berg J, Clancy CJ, Nguyen MH. 1998. The hidden danger of primary fluconazole prophylaxis for patients with AIDS. Clin. Infect. Dis. 26:186-187. (Pubitemid 28068178)
    • (1998) Clinical Infectious Diseases , vol.26 , Issue.1 , pp. 186-187
    • Berg, J.1    Clancy, C.J.2    Nguyen, M.H.3
  • 4
    • 33750304833 scopus 로고    scopus 로고
    • Symptomatic relapse of HIV-associated cryptococcal meningitis after initial huconazole monotherapy: The role of fluconazole resistance and immune reconstitution
    • DOI 10.1086/507895
    • Bicanic T, Harrison T, Niepieklo A, Dyakopu N, Meintjes G. 2006. Symptomatic relapse of HIV-associated cryptococcal meningitis after initial fluconazole monotherapy: the role of fluconazole resistance and immune reconstitution. Clin. Infect. Dis. 43:1069-1073. (Pubitemid 44631110)
    • (2006) Clinical Infectious Diseases , vol.43 , Issue.8 , pp. 1069-1073
    • Bicanic, T.1    Harrison, T.2    Niepieklo, A.3    Dyakopu, N.4    Meintjes, G.5
  • 7
    • 2542494102 scopus 로고    scopus 로고
    • Application of real-time quantitative PCR to molecular analysis of Candida albicans strains exhibiting reduced susceptibility to azoles
    • Chau AS, Mendrick CA, Sabatelli FJ, Loebenberg D, McNicholas PM. 2004. Application of real-time quantitative PCR to molecular analysis of Candida albicans strains exhibiting reduced susceptibility to azoles. Antimicrob. Agents Chemother. 48:2124 -2131.
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 2124-2131
    • Chau, A.S.1    Mendrick, C.A.2    Sabatelli, F.J.3    Loebenberg, D.4    McNicholas, P.M.5
  • 8
    • 62949225044 scopus 로고    scopus 로고
    • Clinical and Laboratory Standards Institute. approved standard, 3rd ed.CLSI document M27-A3. Clinical and Laboratory Standards Institute, Wayne, PA
    • Clinical and Laboratory Standards Institute. 2008.Reference method for broth dilution antifungal susceptibility testing of yeasts; approved standard, 3rd ed.CLSI document M27-A3. Clinical and Laboratory Standards Institute, Wayne, PA.
    • (2008) Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts
  • 9
    • 0037417050 scopus 로고    scopus 로고
    • A point mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus
    • Diaz-Guerra TM, Mellado E, Cuenca-Estrella M, Rodriguez-Tudela JL. 2003. A point mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus. Antimicrob. Agents Chemother. 47:1120-1124.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 1120-1124
    • Diaz-Guerra, T.M.1    Mellado, E.2    Cuenca-Estrella, M.3    Rodriguez-Tudela, J.L.4
  • 10
    • 0035941394 scopus 로고    scopus 로고
    • Development of azole resistance during fluconazole maintenance therapy for AIDS-associated cryptococcal disease [4]
    • DOI 10.1097/00002030-200111230-00026
    • Friese G, Discher T, Fussle R, Schmalreck A, Lohmeyer J. 2001. Development of azole resistance during fluconazole maintenance therapy for AIDS-associated cryptococcal disease. AIDS 15:2344-2345. (Pubitemid 34059852)
    • (2001) AIDS , vol.15 , Issue.17 , pp. 2344-2345
    • Friese, G.1    Discher, T.2    Fussle, R.3    Schmalreck, A.4    Lohmeyer, J.5
  • 13
    • 0041664878 scopus 로고    scopus 로고
    • Conservation in the CYP51 family. Role of the B= helix/BC loop and helices F and G in enzymatic function
    • DOI 10.1021/bi034663f
    • Lepesheva GI, Virus C, Waterman MR. 2003. Conservation in the CYP51 family. Role of the B= helix/BC loop and helices F and G in enzymatic function. Biochemistry 42:9091-9101. (Pubitemid 36935417)
    • (2003) Biochemistry , vol.42 , Issue.30 , pp. 9091-9101
    • Lepesheva, G.I.1    Virus, C.2    Waterman, M.R.3
  • 16
    • 77749291956 scopus 로고    scopus 로고
    • Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: New substitutions and a review of the literature
    • Morio F, Loge C, Besse B, Hennequin C, Le Pape P. 2010. Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature. Diagn. Microbiol. Infect. Dis. 66:373-384.
    • (2010) Diagn. Microbiol. Infect. Dis. , vol.66 , pp. 373-384
    • Morio, F.1    Loge, C.2    Besse, B.3    Hennequin, C.4    Le Pape, P.5
  • 17
    • 58049098654 scopus 로고    scopus 로고
    • Sterol 24-C-methyltransferase: An enzymatic target for the disruption of ergosterol biosynthesis and homeostasis in Cryptococcus neoformans
    • Nes WD, et al. 2009. Sterol 24-C-methyltransferase: an enzymatic target for the disruption of ergosterol biosynthesis and homeostasis in Cryptococcus neoformans. Arch. Biochem. Biophys. 481:210-218.
    • (2009) Arch. Biochem. Biophys. , vol.481 , pp. 210-218
    • Nes, W.D.1
  • 22
    • 0033047485 scopus 로고    scopus 로고
    • A comparison of itraconazole versus fluconazole as maintenance therapy for AIDS-associated cryptococcal meningitis
    • National Institute of Allergy and Infectious Diseases Mycoses Study Group
    • Saag MS, et al. 1999. A comparison of itraconazole versus fluconazole as maintenance therapy for AIDS-associated cryptococcal meningitis. National Institute of Allergy and Infectious Diseases Mycoses Study Group. Clin. Infect. Dis. 28:291-296.
    • (1999) Clin. Infect. Dis. , vol.28 , pp. 291-296
    • Saag, M.S.1
  • 23
    • 67749102047 scopus 로고    scopus 로고
    • Three-dimensional model of lanosterol 14 alpha-demethylase from Cryptococcus neoformans: Active-site characterization and insights into azole binding
    • Sheng C, et al. 2009. Three-dimensional model of lanosterol 14 alpha-demethylase from Cryptococcus neoformans: active-site characterization and insights into azole binding. Antimicrob. Agents Chemother. 53:3487-3495.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 3487-3495
    • Sheng, C.1
  • 24
    • 67650003683 scopus 로고    scopus 로고
    • Hetero-resistance to fluconazole in Cryptococcus neoformans is intrinsic and associated with virulence
    • Sionov E, Chang YC, Garraffo HM, Kwon-Chung KJ. 2009. Hetero-resistance to fluconazole in Cryptococcus neoformans is intrinsic and associated with virulence. Antimicrob. Agents Chemother. 53:2804-2815.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 2804-2815
    • Sionov, E.1    Chang, Y.C.2    Garraffo, H.M.3    Kwon-Chung, K.J.4
  • 25
    • 77954047286 scopus 로고    scopus 로고
    • Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes
    • Sionov E, Lee H, Chang YC, Kwon-Chung KJ. 2010. Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes. PLoS Pathog. 6:e1000848.
    • (2010) PLoS Pathog. , vol.6
    • Sionov, E.1    Lee, H.2    Chang, Y.C.3    Kwon-Chung, K.J.4
  • 26
    • 0027441959 scopus 로고
    • Effects of itraconazole on cytochrome P-450-dependent sterol 14 alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans
    • Vanden Bossche H, et al. 1993. Effects of itraconazole on cytochrome P-450-dependent sterol 14 alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans. Antimicrob. Agents Chemother. 37:2101-2105.
    • (1993) Antimicrob. Agents Chemother. , vol.37 , pp. 2101-2105
    • Vanden Bossche, H.1
  • 27
    • 77952638521 scopus 로고    scopus 로고
    • Heteroresistance of Cryptococcus gattii to fluconazole
    • Varma A, Kwon-Chung KJ. 2010. Heteroresistance of Cryptococcus gattii to fluconazole. Antimicrob. Agents Chemother. 54:2303-2311.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 2303-2311
    • Varma, A.1    Kwon-Chung, K.J.2
  • 29
    • 33749189082 scopus 로고    scopus 로고
    • Activity of newer triazoles against Histoplasma capsulatum from patients with AIDS who failed fluconazole
    • Wheat LJ, et al. 2006. Activity of newer triazoles against Histoplasma capsulatum from patients with AIDS who failed fluconazole. J. Antimicrob. Chemother. 57:1235-1239.
    • (2006) J. Antimicrob. Chemother. , vol.57 , pp. 1235-1239
    • Wheat, L.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.