Monoclonal antibody that blocks the toll-like receptor 5 binding region of flagellin

Hybridoma

Volumn 31, Issue 1, 2012, Pages 60-62

  Li, Yaoming ^a   Liu, Fang ^a   Han, Chen ^a   Yan, Huimin ^a,b  

^a WUHAN INSTITUTE OF VIROLOGY   (China)

^b WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; FLAGELLIN; INTERLEUKIN 8; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 5G10; MONOCYTE CHEMOTACTIC PROTEIN 1; TOLL LIKE RECEPTOR 5; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY PRODUCTION; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; CROSS REACTION; CYTOKINE PRODUCTION; CYTOSOL; HOST RESISTANCE; HUMAN; HUMAN CELL; HYBRIDIZATION; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; CACO-2 CELLS; EPITOPE MAPPING; FEMALE; FLAGELLIN; HUMANS; INTERLEUKIN-8; MICE; MICE, INBRED BALB C; TOLL-LIKE RECEPTOR 5;

EID: 84863159919     PISSN: 15540014     EISSN: 15578348     Source Type: Journal    
DOI: 10.1089/hyb.2011.0083     Document Type: Article

References (11)

1. Eaves-Pyles TD, Wong HR, Odoms K, and Pyles RB: Salmonella flagellin-dependent proinflammatory responses are localized to the conserved amino and carboxyl regions of the protein. J Immunol 2001;167:7009-7016. (Pubitemid 33144196)
2. Zeng H, Carlson AQ, Guo Y, Yu Y, Collier-Hyams LS, Madara JL, Gewirtz AT, and Neish AS: Flagellin is the major proinflammatory determinant of enteropathogenic Salmonella. J Immunol 2003;171:3668-3674. (Pubitemid 37254570)
3. Andersen-Nissen E, Smith KD, Strobe KL, Barrett SL, Cookson BT, Logan SM, and Aderem A: Evasion of Toll-like receptor 5 by flagellated bacteria. Proc Natl Acad Sci USA 2005;102:9247-9252. (Pubitemid 40923549)
4. Feuillet V, Medjane S, Mondor I, Demaria O, Pagni PP, Galan JE, Flavell RA, and Alexopoulou L: Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria. Proc Natl Acad Sci USA 2006;103:12487-12492. (Pubitemid 44274883)
5. Miao EA, Alpuche-Aranda CM, Dors M, Clark AE, Bader MW, Miller SI, and Aderem A: Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1b via Ipaf. Nat Immunol 2006;7:569-575. (Pubitemid 43797337)
6. Franchi L, Amer A, Body-Malapel M, Kanneganti T, Ozoren N, Jagirdar R, Inohara N, Vandenabeele P, Bertin J, Coyle A, Grant EP, and Nunez G: Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1b in salmonella-infected macrophages. Nat Immunol 2006;7:376-382.
7. Liu F, Yang J, Zhang Y, Zhou D, Chen Y, Gai W, Shi W, Li Q, Tien P, and Yan H: Recombinant flagellins with partial deletions of the hypervariable domain lose antigenicity but not mucosal adjuvancy. Biochem Biophys Res Commun 2010;329:582-587.
8. Li Y, Hou L, Ye J, Liu X, Dan H, Jin M, Chen H, and Cao S: Development of a convenient immunochromatographic strip for the diagnosis of infection with Japanese encephalitis virus in swine. J Virol Methods 2010;168:51-56.
9. Jacchieri SG, Torquato R, and Brentani RR: Structural study of binding of flagellin by Toll-like receptor 5. J Bacteriol 2003;185:4243-4247. (Pubitemid 36835265)
10. Steiner TS: How flagellin and toll-like receptor 5 contribute to enteric infection. Infect Immun 2007;75:545-552. (Pubitemid 46203416)
11. Lodes MJ, Cong Y, Elson CO, Mohamath R, Landers CJ, Targan SR, Madeline F, and Hershberg RM: Bacterial fla-gellin is a dominant antigen in Crohn's disease. J Clin Invest 2004;113:1296-1306. (Pubitemid 39069929)