Mutation of a positively charged cytoplasmic motif within CD1d results in multiple defects in antigen presentation to NKT cells

Journal of Immunology

Volumn 188, Issue 5, 2012, Pages 2235-2243

  Shin, Jung Hoon ^a   Park, Ji Young ^a   Shin, Young Hyun ^a   Lee, Hyunji ^a   Park, Yoon Kyung ^a   Jung, Sundo ^a   Park, Se Ho ^a  

^a Korea University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ARGININE; CD1D ANTIGEN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CELL SURFACE; CONTROLLED STUDY; CYTOPLASM; DENDRITIC CELL; INTRACELLULAR TRANSPORT; LYSOSOME; MOUSE; MUTATION; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF;

AMINO ACID MOTIFS; ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD1D; ARGININE; CELL LINE, TUMOR; CELL MEMBRANE; CYTOPLASM; INTRACELLULAR FLUID; LYSOSOMES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTAGENESIS, SITE-DIRECTED; NATURAL KILLER T-CELLS; PROTEIN TRANSPORT; SEQUENCE DELETION; STATIC ELECTRICITY;

EID: 84863149929     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1100236     Document Type: Article

References (31)

1. Calabi, F., J. M. Jarvis, L. Martin, and C. Milstein. 1989. Two classes of CD1 genes. Eur. J. Immunol. 19: 285-292. (Pubitemid 19098904)
2. Porcelli, S. A. 1995. The CD1 family: a third lineage of antigen-presenting molecules. Adv. Immunol. 59: 1-98.
3. Porcelli, S. A., and R. L. Modlin. 1999. The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids. Annu. Rev. Immunol. 17: 297-329. (Pubitemid 29241127)
4. Park, S. H., and A. Bendelac. 2000. CD1-restricted T-cell responses and microbial infection. Nature 406: 788-792.
5. Brossay, L., N. Burdin, S. Tangri, and M. Kronenberg. 1998. Antigen-presenting function of mouse CD1: one molecule with two different kinds of antigenic ligands. Immunol. Rev. 163: 139-150. (Pubitemid 28327867)
6. De Libero, G., and L. Mori. 2005. Recognition of lipid antigens by T cells. Nat. Rev. Immunol. 5: 485-496. (Pubitemid 40835036)
7. Brossay, L., S. Tangri, M. Bix, S. Cardell, R. Locksley, and M. Kronenberg. 1998. Mouse CD1-autoreactive T cells have diverse patterns of reactivity to CD1+ targets. J. Immunol. 160: 3681-3688. (Pubitemid 28176068)
8. Park, S. H., J. H. Roark, and A. Bendelac. 1998. Tissue-specific recognition of mouse CD1 molecules. J. Immunol. 160: 3128-3134. (Pubitemid 28164700)
9. Behar, S. M., T. A. Podrebarac, C. J. Roy, C. R. Wang, and M. B. Brenner. 1999. Diverse TCRs recognize murine CD1. J. Immunol. 162: 161-167. (Pubitemid 29018916)
10. Hava, D. L., M. Brigl, P. van den Elzen, D. M. Zajonc, I. A. Wilson, and M. B. Brenner. 2005. CD1 assembly and the formation of CD1-antigen complexes. Curr. Opin. Immunol. 17: 88-94. (Pubitemid 40094019)
11. Jayawardena-Wolf, J., K. Benlagha, Y. H. Chiu, R. Mehr, and A. Bendelac. 2001. CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain. Immunity 15: 897-908. (Pubitemid 34075371)
12. Chiu, Y. H., S. H. Park, K. Benlagha, C. Forestier, J. Jayawardena-Wolf, P. B. Savage, L. Teyton, and A. Bendelac. 2002. Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1d. Nat. Immunol. 3: 55-60. (Pubitemid 34065618)
13. Roberts, T. J., V. Sriram, P. M. Spence, M. Gui, K. Hayakawa, I. Bacik, J. R. Bennink, J. W. Yewdell, and R. R. Brutkiewicz. 2002. Recycling CD1d1 molecules present endogenous antigens processed in an endocytic compartment to NKT cells. J. Immunol. 168: 5409-5414. (Pubitemid 34556117)
14. Zhou, D., J. Mattner, C. Cantu, III, N. Schrantz, N. Yin, Y. Gao, Y. Sagiv, K. Hudspeth, Y. P. Wu, T. Yamashita, et al. 2004. Lysosomal glycosphingolipid recognition by NKT cells. Science 306: 1786-1789. (Pubitemid 39601398)
15. Zhou, D., C. Cantu, III, Y. Sagiv, N. Schrantz, A. B. Kulkarni, X. Qi, D. J. Mahuran, C. R. Morales, G. A. Grabowski, K. Benlagha, et al. 2004. Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins. Science 303: 523-527. (Pubitemid 38120850)
16. Prigozy, T. I., O. Naidenko, P. Qasba, D. Elewaut, L. Brossay, A. Khurana, T. Natori, Y. Koezuka, A. Kulkarni, and M. Kronenberg. 2001. Glycolipid antigen processing for presentation by CD1d molecules. Science 291: 664-667. (Pubitemid 32150427)
17. Cernadas, M., M. Sugita, N. van der Wel, X. Cao, J. E. Gumperz, S. Maltsev, G. S. Besra, S. M. Behar, P. J. Peters, and M. B. Brenner. 2003. Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development. J. Immunol. 171: 4149-4155. (Pubitemid 37238691)
18. Elewaut, D., A. P. Lawton, N. A. Nagarajan, E. Maverakis, A. Khurana, S. Honing, C. A. Benedict, E. Sercarz, O. Bakke, M. Kronenberg, and T. I. Prigozy. 2003. The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Valpha14i NKT cells. J. Exp. Med. 198: 1133-1146. (Pubitemid 37323379)
19. Lawton, A. P., T. I. Prigozy, L. Brossay, B. Pei, A. Khurana, D. Martin, T. Zhu, K. Späte, M. Ozga, S. Höning, et al. 2005. The mouse CD1d cytoplasmic tail mediates CD1d trafficking and antigen presentation by adaptor protein 3-dependent and -independent mechanisms. J. Immunol. 174: 3179-3186. (Pubitemid 40354019)
20. Sugita, M., X. Cao, G. F. Watts, R. A. Rogers, J. S. Bonifacino, and M. B. Brenner. 2002. Failure of trafficking and antigen presentation by CD1 in AP-3-deficient cells. Immunity 16: 697-706. (Pubitemid 34626690)
21. Park, Y. K., J. W. Lee, Y. G. Ko, S. Hong, and S. H. Park. 2005. Lipid rafts are required for efficient signal transduction by CD1d. Biochem. Biophys. Res. Commun. 327: 1143-1154. (Pubitemid 40137986)
22. Sagiv, Y., L. Bai, D. G. Wei, R. Agami, P. B. Savage, L. Teyton, and A. Bendelac. 2007. A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d. J. Exp. Med. 204: 921-928. (Pubitemid 46631619)
23. Grebe, K. M., and T. A. Potter. 2002. Enumeration, phenotyping, and identification of activation events in conjugates between T cells and antigen-presenting cells by flow cytometry. Sci. STKE 2002: pl14.
24. Chiu, Y. H., J. Jayawardena, A. Weiss, D. Lee, S. H. Park, A. Dautry-Varsat, and A. Bendelac. 1999. Distinct subsets of CD1d-restricted T cells recognize self-antigens loaded in different cellular compartments. J. Exp. Med. 189: 103-110. (Pubitemid 29047030)
25. Lang, G. A., S. D. Maltsev, G. S. Besra, and M. L. Lang. 2004. Presentation of alpha-galactosylceramide by murine CD1d to natural killer T cells is facilitated by plasma membrane glycolipid rafts. Immunology 112: 386-396. (Pubitemid 38859516)
26. Kawano, T., J. Cui, Y. Koezuka, I. Toura, Y. Kaneko, K. Motoki, H. Ueno, R. Nakagawa, H. Sato, E. Kondo, et al. 1997. CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. Science 278: 1626-1629. (Pubitemid 27516282)
27. Bai, L., Y. Sagiv, Y. Liu, S. Freigang, K. O. Yu, L. Teyton, S. A. Porcelli, P. B. Savage, and A. Bendelac. 2009. Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen alphaGalCer. Proc. Natl. Acad. Sci. USA 106: 10254-10259.
28. Roy, K. C., I. Maricic, A. Khurana, T. R. Smith, R. C. Halder, and V. Kumar. 2008. Involvement of secretory and endosomal compartments in presentation of an exogenous self-glycolipid to type II NKT cells. J. Immunol. 180: 2942-2950.
29. Roark, J. H., S. H. Park, J. Jayawardena, U. Kavita, M. Shannon, and A. Bendelac. 1998. CD1.1 expression by mouse antigen-presenting cells and marginal zone B cells. J. Immunol. 160: 3121-3127. (Pubitemid 28164699)
30. Yu, K. O., J. S. Im, P. A. Illarionov, R. M. Ndonye, A. R. Howell, G. S. Besra, and S. A. Porcelli. 2007. Production and characterization of monoclonal antibodies against complexes of the NKT cell ligand alpha-galactosylceramide bound to mouse CD1d. J. Immunol. Methods 323: 11-23. (Pubitemid 46719203)
31. Liu, J., D. Shaji, S. Cho, W. Du, J. Gervay-Hague, and R. R. Brutkiewicz. 2010. A threonine-based targeting signal in the human CD1d cytoplasmic tail controls its functional expression. J. Immunol. 184: 4973-4981.