Antifibrinolytic role of a bee venom serine protease inhibitor that acts as a plasmin inhibitor

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Choo, Young Moo ^a   Lee, Kwang Sik ^a   Yoon, Hyung Joo ^b   Qiu, Yuling ^a   Wan, Hu ^a   Sohn, Mi Ri ^a   Da Sohn, Hunge ^a   Jin, Byung Rae ^a  

^a Dong A University   (South Korea)

^b National Academy of Agricultural Science   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFIBRINOLYTIC AGENT; APROTININ; BEE VENOM; BLOOD CLOTTING FACTOR 10A; PLASMIN; PLASMIN INHIBITOR; SERINE PROTEINASE INHIBITOR; THROMBIN; TISSUE PLASMINOGEN ACTIVATOR; FIBRINOLYTIC AGENT;

ARTICLE; BOMBUS IGNITUS; BUMBLEBEE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; EXPRESSED SEQUENCE TAG; FIBRINOLYSIS; GENETIC CODE; HEMOSTASIS; IC 50; NONHUMAN; NUCLEOTIDE SEQUENCE; SEQUENCE ALIGNMENT; ANIMAL; BEE; CHEMISTRY; DRUG ANTAGONISM; HUMAN; ISOLATION AND PURIFICATION;

ANIMALS; ANTIFIBRINOLYTIC AGENTS; BEE VENOMS; BEES; FIBRINOLYSIN; FIBRINOLYTIC AGENTS; HEMOSTASIS; HUMANS; SERINE PROTEINASE INHIBITORS;

EID: 84863138374     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032269     Document Type: Article

References (25)

1. Neurath H, (1984) Evolution of proteolytic enzymes. Science 224: 350-357.
2. Krem MM, Cera ED, (2002) Evolution of enzyme cascades from embryonic development to blood coagulation. Trends Biochem Sci 27: 67-74.
3. van Gent D, Sharp P, Morgan K, Kalsheker N, (2003) Serpins: structure, function and molecular evolution. Int J Biochem Cell Biol 35: 1536-1547.
4. Braud S, Bon C, Wisner A, (2000) Snake venom proteins acting on hemostasis. Biochimie 82: 851-859.
5. Matsui T, Fujimura Y, Titani K, (2000) Snake venom proteases affecting hemostasis and thrombisis. Biochim Biophys Acta 1477: 146-156.
6. Kini RM, (2005) Serine proteases affecting blood coagulation and fibrinolysis from snake venoms. Pathophysiol Haemost Thrombo 34: 200-204.
7. Masci PP, Whitaker AN, Sparrow LG, de Jersey J, Winzor DJ, et al. (2000) Textilinins from Pseudonaja textilis textilis. Characterization of two plasmin inhibitors that reduce bleeding in an animal model. Blood Coagul Fibrinolysis 11: 385-393.
8. Flight S, Johnson L, Trabi M, Gaffney P, Lavin M, et al. (2005) Comparison of textinin-1 with aprotinin as serine protease inhibitors and as antifibrinolytic agents. Pathophysiol Haemost Thromb 34: 188-193.
9. Flight SM, Johnson LA, Du QS, Warner RL, Trabi M, et al. (2009) Textilinin-1, an alternative anti-bleeding agent to aprotinin: Importance of plasmin inhibition in controlling blood loss. British J Hematol 145: 207-211.
10. Miller EKI, Trabi M, Masci PP, Lavin MF, de Jersey J, et al. (2009) Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textiles). FEBS J 276: 3163-3175.
11. Xin Y, Choo YM, Hu Z, Lee KS, Yoon HJ, et al. (2009) Molecular cloning and characterization of a venom phospholipase A2 from the bumblebee Bombus ignitus. Comp Biochem Physiol B 154: 195-202.
12. Choo YM, Lee KS, Yoon HJ, Je YH, Lee SW, et al. (2010a) Molecular cloning and antimicrobial activity of bombolitin, a component of bumblebee Bombus ignitus venom. Comp Biochem Physiol B 156: 168-173.
13. Choo YM, Lee KS, Yoon HJ, Kim BY, Sohn MR, et al. (2010b) Dual strategy of bee venom serine protease: prophenoloxidase-activating factor in arthropods and fibrin(ogen)olytic enzyme in mammals. PLoS ONE 5: e10393.
14. Qiu Y, Choo YM, Yoon HJ, Jia J, Cui Z, et al. (2011) Fibrin(ogen)olytic activity of bumblebee venom serine protease. Toxicol Appl Pharmacol 255: 207-213.
15. Shafqat J, Zaidi ZH, Jornvall H, (1990) Purification and characterization of a chymotrpsin Kunitz inhibitor type of polypeptide from the venom of cobra (Naja naja naja). FEBS Lett 275: 6-8.
16. Siddigi AR, Zaidi ZH, Jornvall H, (1991) Purification and characterization of a Kunitz-type trpsin inhibitor from leaf-nosed viper venom. FEBS Lett 294: 141-143.
17. Lu J, Yang H, Yu H, Gao W, Lai R, et al. (2008) A novel serine protease inhibitor from Bungarus fasciatus venom. Peptides 29: 369-374.
18. Hider RC, (1988) Honeybee venom: a rich source of pharmacologically active peptides. Endeavour 12: 60-65.
19. Son DJ, Lee JW, Lee YH, Song HS, Lee CK, et al. (2007) Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds. Pharmacol Ther 115: 246-270.
20. Davis R, Whittington R, (1995) Aprotinin. A review of its pharmacology and therapeutic efficacy in reducing blood loss associated with cardiac surgery. Drugs 49: 954-983.
21. Segal H, (2000) Aprotinin: pharmacological reduction of perioperative bleeding. Lancet 355: 1289-1290.
22. Roystone D, (1990) The serine antiprotease aprotinin (Trasylol™): a novel approach to reducing postoperative bleeding. Blood Coagul Fibrinolysis 1: 53-69.
23. Koh YS, Chung KH, Kim DS, (2001) Biochemical characterization of a thrombin-like enzyme and a fibrinolytic serine protease from snake (Agkistrodon saxatilis) venom. Toxicon 39: 555-560.
24. He J, Chen S, Gu J, (2007) Identification and characterization of Harobin, a novel fibrin(ogen)olytic serine protease from a sea snake (Lapemis hardwickii). FEBS Lett 581: 2965-2973.
25. Sinauridze EL, Romanov AN, Gribkova IV, Kondakova OA, Surov SS, et al. (2011) New synthetic thrombin inhibitors: molecular design and experimental verification. PLoS ONE 6: e19969.