Biochemical characterization of a thrombin-like enzyme and a fibrinolytic serine protease from snake (Agkistrodon saxatilis) venom

Toxicon

Volumn 39, Issue 4, 2001, Pages 555-560

  Koh, You Seok ^a   Chung, Kwang Hoe ^b   Kim, Doo Sik ^a  

^a Bioproducts Research Center   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

Fibrinogen clotting; Fibrinolytic enzyme; Snake venom; Thrombin like enzyme

Indexed keywords

ANCROD; BATROXOBIN; CARBOHYDRATE; FIBRINOGEN; PROTEINASE INHIBITOR; SERINE PROTEINASE; SNAKE VENOM; THROMBIN;

AGKISTRODON; AGKISTRODON SAXATILIS; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BLOOD VISCOSITY; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME SPECIFICITY; FIBRINOGENOLYSIS; FIBRINOLYSIS; MOLECULAR WEIGHT; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PURIFICATION; SNAKE;

EID: 0342844374     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(00)00169-0     Document Type: Article

References (14)

1. Astrup T., Mullertz S. The fibrin plate method for the estimation of fibrinolytic activity. Arch. Biochem. Biophys. 40:1952;346-351.
2. Au L.C., Lin S.B., Chou J.S., Teh G.W., Chang K.J., Shih C.M. Molecular cloning and sequence analysis of the cDNA for ancrod, a thrombin-like enzyme from the venom of Calloselasma rhodostoma. Biochem. J. 294:1993;387-390.
3. Chang M.C., Huang T.F. The antiplatelet activity of ancrod on administration to rabbits. J. Lab. Clin. Med. 125:1995;508-516.
4. Esnouf M.P., Tunnah G.W. The isolation and properties of the thrombin-like activity from Ancistrodon rhodostoma venom. Brit. J. Haematol. 13:1967;581-590.
5. Hofmann H., Dumarey C., Bon C. Blood coagulation induced by Bothrops atrox venom: identification and properties of a factor X activator. Biochimie. 65:1983;201-210.
6. Itoh N., Tanaka N., Funakoshi I., Kawasaki T., Mihashi S., Yamashina I. Organization of the gene for batroxobin, a thrombin-like snake venom enzyme. Homology with the trypsin/kallikrein gene family. J. Biol. Chem. 263:1988;7628-7631.
7. Jandrot-Perrus M., Huisse M.G., Krstenansky J.L., Bezeaud A., Guillin M.C. Effect of the hirudin carboxy-terminal peptide 54-65 on the interaction of thrombin with platelets. Thromb. Haemost. 66:1991;300-305.
8. Markland F.S., Damus P.S. Purification and properties of a thrombin-like enzyme from the venom of Crotalus adamanteus (Eastern diamond back rattle-snake). J. Biol. Chem. 246:1971;6460-6473.
9. Matsui T., Sakurai Y., Fujimura Y., Hayashi I., Oh-Ishi S., Suzuki M., Hamako J., Yamamoto Y., Yamazaki J., Kinoshita M., Titani K. Purification and amino acid sequence of halystase from snake venom of Agkistrodon halys blomhoffii, a serine protease that cleaves specifically fibrinogen and kininogen. Eur. J. Biochem. 252:1998;569-575.
10. Pan H., Du X., Yang G., Zhou Y., Wu X. cDNA cloning and expression of acutin. Biochem. Biophys. Res. Commun. 255:1999;412-415.
11. Shieh T.C., Kawabata S.I., Kihara H., Ohno M., Iwanaga S. Amino acid sequence of a coagulant enzyme, flavoxobin, from Trimeresurus flavoviridis venom. J. Biochem. 103:1988;596-605.
12. Siigur E., Siigur J. Purification and characterization of lebetase, a fibrinolytic enzyme from Vipera lebetina (snake) venom. Biochem. Biophys. Acta. 1074:1991;223-229.
13. Siigur J., Samel M., Tonismagi K., Subbi J., Siigur E., Tu A.T. Biochemical characterization of lebetase, a direct-acting fibrinolytic enzyme from Vipera lebetina snake venom. Thromb. Res. 90:1998;39-49.
14. Stocker K.F. Snake venom proteins affecting hemostasis and fibrinolysis. Stocker K.F. Medical Use of Snake Venom Proteins. 1990;97-160 CRC Press, Boca Raton.