Functional desaturase fads1 (δ5) and fads2 (δ6) orthologues evolved before the origin of jawed vertebrates

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Costa, Luís Filipe Costa ^a   Monroig, Óscar ^b   Leaver, Michael J ^c   Wilson, Jonathan ^a   Cunha, Isabel ^a   Tocher, Douglas R ^c  

^a UNIVERSITY OF PORTO   (Portugal)

^b CSIC Instituto de Acuicultura de Torre de la Sal IATS   (Spain)

^c UNIVERSITY OF STIRLING   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; DELTA 5 FATTY ACID DESATURASE; DELTA-5 FATTY ACID DESATURASE; FADS2 PROTEIN, HUMAN; FATTY ACID; LINOLEIC ACID; LINOLENIC ACID;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; BIOLOGY; CATSHARK; CHEMISTRY; CLUSTER ANALYSIS; CONTROLLED STUDY; DOG; ENZYME ACTIVITY; EVOLUTION; FADS1 GENE; FADS2 GENE; FADS4 GENE; FATTY ACID METABOLISM; FISH; FUNCTIONAL GENOMICS; GENE; GENE DUPLICATION; GENE FUNCTION; GENE IDENTIFICATION; GENE LOSS; GENETIC CONSERVATION; GENETIC VARIABILITY; GENOMICS; HUMAN; MAMMAL; MARKER GENE; METABOLISM; METHODOLOGY; MOLECULAR EVOLUTION; MOUSE; NONHUMAN; ORTHOLOGY; PHYLOGENY; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; SHARK; SPECIES DIFFERENCE; STATISTICAL MODEL; TELEOST; VERTEBRATE;

ALPHA-LINOLENIC ACID; ANIMALS; BIOLOGICAL EVOLUTION; CHEMISTRY; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; DOGS; EVOLUTION, MOLECULAR; FATTY ACID DESATURASES; FATTY ACIDS; FISHES; HUMANS; LIKELIHOOD FUNCTIONS; LINOLEIC ACID; METABOLISM; METHODS; MICE; MODELS, GENETIC; PHYLOGENY; SACCHAROMYCES CEREVISIAE; SHARKS; VERTEBRATES;

AVES; GNATHOSTOMATA (VERTEBRATE); MAMMALIA; REPTILIA; SCYLIORHINUS CANICULA; TELEOSTEI; VERTEBRATA;

EID: 84863130946     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031950     Document Type: Article

References (44)

1. Tocher DR, (2003) Metabolism and functions of lipids and fatty acids in teleost fish. Rev Fisheries Sci 11: 107-184.
2. Tocher DR, (2010) Fatty acid requirements in ontogeny of marine and freshwater fish. Aquaculture Res 41: 717-732.
3. Burdge GC, Calder PC, (2005) Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. Reprod Nutr Dev 45: 581-97.
4. Rivers JPW, Sinclair AJ, Crawford MA, (1975) Inability of the cat to desaturate essential fatty acids. Nature 258: 171-173.
5. Cook HW, McMaster RCR, (2004) Biochemistry of Lipids, Lipoproteins, and Membranes. In: Vance DE, Vance JE, editors. Amsterdam Elsevier pp. 181-204.
6. Park WJ, Kothapalli KS, Lawrence P, Tyburczy C, Brenna JT, (2009) An alternate pathway to long-chain polyunsaturates: The FADS2 gene product Delta8-desaturates 20:2n-6 and 20:3n-3. J Lipid Res 50: 1195-1202.
7. Monroig O., Li Y, Tocher DR, (2011) Delta-8 desaturation activity varies among fatty acyl desaturases of teleost fish: high activity in delta-6 desaturases of marine species. Comp. Biochem. Physiol 159B: 206-213.
8. Sprecher H, (2000) Metabolism of highly unsaturated n-3 and n-6 fatty acids. Biochim Biophys Acta 1486: 219-231.
9. López Alonso D, López Alonso F, García-Maroto J, Rodríguez-Ruiz JA, Garrido M, et al. (2003) Evolution of the membrane-bound fatty acid desaturases. Biochemical Systematics Ecol 31: 1111-112.
10. Sperling P, Ternes P, Zank TK, Heinz E, (2003) The evolution of desaturases. Prostaglandins Leukot Essent Fatty Acids 68: 73-95.
11. Marquardt A, Stöhr H, White K, Weber BH, (2000) cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. Genomics 66: 175-83.
12. Blanchard H, Legrand P, Pédrono F, (2011) Fatty Acid Desaturase 3 (Fads3) is a singular member of the Fads cluster. Biochimie 93: 87-90.
13. Michaelson LV, Napier JA, Lewis M, Griffiths G, Lazarus CM, et al. (1998) Functional identification of a fatty acid delta5 desaturase gene from Caenorhabditis elegans. FEBS Lett 439: 215-8.
14. Napier JA, Hey SJ, Lacey DJ, Shewry PR, (1998) Identification of a Caenorhabditis elegans Delta6-fatty-acid-desaturase by heterologous expression in Saccharomyces cerevisiae. Biochem J 330: 611-4.
15. Hastings N, Agaba M, Tocher DR, Leaver MJ, Dick JR, et al. (2001) A vertebrate fatty acid desaturase with Delta 5 and Delta 6 activities. Proc Natl Acad Sci U S A 98: 14304-9.
16. Li Y, Monroig O, Zhang L, Wang S, Zheng X, et al. (2010) Vertebrate fatty acyl desaturase with Δ4 activity. Proc Natl Acad Sci U S A 107: 16840-5.
17. Hastings N, Agaba MK, Tocher DR, Zheng X, Dickson CA, et al. (2005) Molecular cloning and functional characterization of fatty acyl desaturase and elongase cDNAs involved in the production of eicosapentaenoic and docosahexaenoic acids from alpha-linolenic acid in Atlantic salmon (Salmo salar). Mar Biotechnol 6: 463-74.
18. Zheng X, Tocher DR, Dickson CA, Bell JG, Teale AJ, (2005) Highly unsaturated fatty acid synthesis in vertebrates: new insights with the cloning and characterization of a delta6 desaturase of Atlantic salmon. Lipids 40: 13-24.
19. Monroig O, Zheng X, Morais S, Leaver MJ, Taggart JB, et al. (2010) Multiple genes for functional Δ6 fatty acyl desaturases (Fad) in Atlantic salmon (Salmo salar L.): Gene and cDNA characterization, functional expression, tissue distribution and nutritional regulation. Biochim Biophys Acta 1801: 1072-81.
20. Tocher DR, Zheng X, Schlechtriem C, Hastings N, Dick JR, et al. (2006) Highly unsaturated fatty acid synthesis in marine fish; cloning, functional characterization and nutritional regulation of fatty acid Δ6 desaturase of Atlantic cod (Gadus morhua L.). Lipids 41: 1003-1016.
21. Zheng X, Seiliez I, Hastings N, Tocher DR, Panserat S, et al. (2004) Characterization and comparison of fatty acyl Δ6 desaturase cDNAs from freshwater and marine teleost fish species. Comp Biochem Physiol 139B: 269-279.
22. Zheng X, Ding Z, Xu Y, Monroig O, Morais S, et al. (2009) Physiological roles of fatty acyl desaturase and elongase in marine fish: Characterisation of cDNAs of fatty acyl Δ6 desaturase and Elovl5 elongase of cobia (Rachycentron canadum). Aquaculture 290: 122-131.
23. Sinclair AJ, McLean JG, Monger EA, (1979) Metabolism of linoleic acid in the cat. Lipids 14: 932-6.
24. Sinclair AJ, Slattery W, McLean JG, Monger EA, (1981) Essential fatty acid deficiency and evidence for arachidonate synthesis in the cat. Br J Nutr 46: 93-6.
25. Leaver MJ, Bautista JM, Björnsson T, Jönsson E, Krey G, et al. (2008) Towards fish lipid nutrigenomics: current state and prospects for fin-fish aquaculture. Rev Fisheries Sci 16 (S1): 71-92.
26. Vanhercke T, Shrestha P, Green AG, Singh SP, (2011) Mechanistic and structural insights into the regioselectivity of an acyl-CoA fatty acid desaturase via directed molecular evolution. J Biol Chem 286: 12860-12869.
27. Sargent JR, Henderson RJ, Tocher DR, (1989) The lipids. pp. 154-219 In Fish Nutrition (Halver JE, ed) 2nd Edition, Ch. 4 Academic Press, San Diego.
28. Sargent JR, Bell JG, Bell MV, Henderson RJ, Tocher DR, (1995) Dietary origins and functions of long-chain (n-3) polyunsaturated fatty acids in marine fish. J Mar Biotechnol 3: 26-28.
29. Gillan FT, Hogg RW, Drew EA, (1984) The sterol and fatty acid compositions of seven tropical seagrasses from North Queensland, Australia. Phytochemistry 23: 2817-2821.
30. Mohd-Yusof NY, Monroig O., Mohd-Adnan A, Wan K-L, Tocher DR, (2010) Investigation of highly unsaturated fatty acid metabolism in the Asian sea bass, Lates calcarifer. Fish Physiol Biochem 36: 827-843.
31. Knoll HA, Summons RE, Waldbauer JR, Zumberge JE, (2007) The geological succession of primary producers in the oceans. In: Falkowski PG, Knoll AH, editors. Evolution of Primary Producers in the Sea Academic Press, New York.
32. Shimeld SM, Holland PW, (2000) Vertebrate innovations. Proc Natl Acad Sci U S A 97: 4449-52.
33. Putnam NH, Butts T, Ferrier DE, Furlong RF, Hellsten U, et al. (2008) The amphioxus genome and the evolution of the chordate karyotype. Nature 453: 1064-1071.
34. Evans H, De Tomaso T, Quail M, Rogers J, Gracey AY, et al. (2008) Ancient and modern duplication events and the evolution of stearoyl-CoA desaturases in teleost fishes. Physiol Genomics 35: 18-29.
35. Castro LF, Wilson JM, Gonçalves O, Galante-Oliveira S, Rocha E, et al. (2011) The evolutionary history of the stearoyl-CoA desaturase gene family in vertebrates. BMC Evol Biol 11: 132.
36. Morais S, Monroig O, Zheng X, Leaver MJ, Tocher DR, (2009) Highly unsaturated fatty acid synthesis in Atlantic salmon: characterisation of ELOVL5- and ELOVL2-like elongases. Mar Biotechnol 11: 627-639.
37. Monroig O, Rotllant J, Sánchez E, Cerdá-Reverter JM, Tocher DR, (2009) Expression of long-chain polyunsaturated fatty acid (LC-PUFA) biosynthesis genes during zebrafish Danio rerio early embryogenesis. Biochim Biophys Acta 1791: 1093-101.
38. Venkatesh B, Kirkness EF, Loh YH, Halpern AL, Lee AP, et al. (2007) Survey sequencing and comparative analysis of the elephant shark (Callorhinchus milii) genome. PLoS Biol 5: e101.
39. Katoh K, Toh H, (2008) Recent developments in the MAFFT multiple sequence alignment program. Brief Bioinform 9: 286-98.
40. Abascal F, Zardoya R, Posada D, (2005) ProtTest: selection of best-fit models of protein evolution. Bioinformatics 21: 2104-2105.
41. Guindon S, Dufayard JF, Lefort V, Anisimova M, Hordijk W, et al. (2010) New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0. Systematic Biol 59: 307-21.
42. Anisimova M, Gascuel O, (2006) Approximate Likelihood-Ratio Test for Branches: A Fast, Accurate, and Powerful Alternative. Systematic Biology 55: 539-552.
43. Perrière G, Gouy M, (1996) WWW-Query: an on-line retrieval system for biological sequence banks. Biochimie 78: 364-369.
44. Agaba M, Tocher DR, Dickson C, Dick JR, Teale AJ, (2004) Zebrafish cDNA encoding multifunctional fatty acid elongase involved in production of eicosapentaenoic (20:5n-3) and docosahexaenoic (22:6n-3) acids. Mar Biotechnol 6: 251-261.