-
1
-
-
80051580618
-
Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths
-
Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011; 61: 212-236.
-
(2011)
CA Cancer J Clin
, vol.61
, pp. 212-236
-
-
Siegel, R.1
Ward, E.2
Brawley, O.3
Jemal, A.4
-
2
-
-
67650924582
-
Pancreatic cancer: Molecular pathogenesis and new therapeutic targets
-
Wong HH, Lemoine NR. Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Nat Rev Gastroenterol Hepatol 2009; 6: 412-422.
-
(2009)
Nat Rev Gastroenterol Hepatol
, vol.6
, pp. 412-422
-
-
Wong, H.H.1
Lemoine, N.R.2
-
4
-
-
36749037264
-
Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression
-
Li M, Zhang Y, Liu Z, et al. Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression. Proc Natl Acad Sci USA 2007; 104: 18636-18641.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 18636-18641
-
-
Li, M.1
Zhang, Y.2
Liu, Z.3
-
5
-
-
70349662179
-
Down-regulation of ZIP4 by RNA interference inhibits pancreatic cancer growth and increases the survival of nude mice with pancreatic cancer xenografts
-
Li M, Zhang Y, Bharadwaj U, et al. Down-regulation of ZIP4 by RNA interference inhibits pancreatic cancer growth and increases the survival of nude mice with pancreatic cancer xenografts. Clin Cancer Res 2009; 15: 5993-6001.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5993-6001
-
-
Li, M.1
Zhang, Y.2
Bharadwaj, U.3
-
6
-
-
79551691442
-
PDX-1: Demonstration of oncogenic properties in pancreatic cancer
-
Liu SH, Patel S, Gingras MC, et al. PDX-1: demonstration of oncogenic properties in pancreatic cancer. Cancer 2011; 117: 723-733.
-
(2011)
Cancer
, vol.117
, pp. 723-733
-
-
Liu, S.H.1
Patel, S.2
Gingras, M.C.3
-
7
-
-
0034828124
-
A novel, clinically relevant animal model of metastatic pancreaticadenocarcinoma biology and therapy
-
Wang B, Shi Q, Abbruzzese J, Xiong Q, Le X, Xie K. A novel, clinically relevant animal model of metastatic pancreaticadenocarcinoma biology and therapy. Int J Gastrointest Cancer 2001; 29: 37-46.
-
(2001)
Int J Gastrointest Cancer
, vol.29
, pp. 37-46
-
-
Wang, B.1
Shi, Q.2
Abbruzzese, J.3
Xiong, Q.4
Le, X.5
Xie, K.6
-
8
-
-
0021330445
-
Induction and chemotherapeutic response of two transplantable ductal adenocarcinomas of the pancreas in C57BL/6 mice
-
Corbett TH, Roberts BJ, Leopold WR, et al. Induction and chemotherapeutic response of two transplantable ductal adenocarcinomas of the pancreas in C57BL/6 mice. Cancer Res 1984; 44: 717-726.
-
(1984)
Cancer Res
, vol.44
, pp. 717-726
-
-
Corbett, T.H.1
Roberts, B.J.2
Leopold, W.R.3
-
9
-
-
62549112118
-
Basic principles and technologies for deciphering the genetic map of cancer
-
Voidonikolas G, Kreml SS, Chen C, et al. Basic principles and technologies for deciphering the genetic map of cancer. World J Surg 2009; 33: 615-629.
-
(2009)
World J Surg
, vol.33
, pp. 615-629
-
-
Voidonikolas, G.1
Kreml, S.S.2
Chen, C.3
-
10
-
-
1542314907
-
Values of mutations of K-ras oncogene at codon 12 in detection of pancreatic cancer: 15-year experience
-
Mu DQ, Peng YS, Xu QJ. Values of mutations of K-ras oncogene at codon 12 in detection of pancreatic cancer: 15-year experience. World J Gastroenterol 2004; 10: 471-475.
-
(2004)
World J Gastroenterol
, vol.10
, pp. 471-475
-
-
Mu, D.Q.1
Peng, Y.S.2
Xu, Q.J.3
-
11
-
-
68049115773
-
SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer
-
Blackford A, Serrano OK, Wolfgang CL, et al. SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res 2009; 15: 4674-4679.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4674-4679
-
-
Blackford, A.1
Serrano, O.K.2
Wolfgang, C.L.3
-
13
-
-
0029715628
-
CDKN2A (p16INK4A) somatic and germline mutations
-
Smith-Sorensen B, Hovig E. CDKN2A (p16INK4A) somatic and germline mutations. Hum Mutat 1996; 7: 294-303.
-
(1996)
Hum Mutat
, vol.7
, pp. 294-303
-
-
Smith-Sorensen, B.1
Hovig, E.2
-
14
-
-
78650015522
-
The role of mutant p53 in human cancer
-
Goh AM, Coffill CR, Lane DP. The role of mutant p53 in human cancer. J Pathol 2011; 223: 116-126.
-
(2011)
J Pathol
, vol.223
, pp. 116-126
-
-
Goh, A.M.1
Coffill, C.R.2
Lane, D.P.3
-
15
-
-
2142686652
-
Mutation spectrum of human SLC39A4 in a panel of patients with acrodermatitis enteropathica
-
Kury S, Kharfi M, Kamoun R, et al. Mutation spectrum of human SLC39A4 in a panel of patients with acrodermatitis enteropathica. Hum Mutat 2003; 22: 337-338.
-
(2003)
Hum Mutat
, vol.22
, pp. 337-338
-
-
Kury, S.1
Kharfi, M.2
Kamoun, R.3
-
16
-
-
0036308552
-
A novel member of a zinc transporter family is defective in acrodermatitis enteropathica
-
Wang K, Zhou B, Kuo YM, Zemansky J, Gitschier J. A novel member of a zinc transporter family is defective in acrodermatitis enteropathica. Am J Hum Genet 2002; 71: 66-73.
-
(2002)
Am J Hum Genet
, vol.71
, pp. 66-73
-
-
Wang, K.1
Zhou, B.2
Kuo, Y.M.3
Zemansky, J.4
Gitschier, J.5
-
17
-
-
0032742985
-
Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes
-
Macfarlane WM, Frayling TM, Ellard S, et al. Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes. J Clin Invest 1999; 104: R33-R39.
-
(1999)
J Clin Invest
, vol.104
-
-
Macfarlane, W.M.1
Frayling, T.M.2
Ellard, S.3
-
18
-
-
0032718689
-
Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus
-
Hani EH, Stoffers DA, Chevre JC, et al. Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus. J Clin Invest 1999; 104: R41-R48.
-
(1999)
J Clin Invest
, vol.104
-
-
Hani, E.H.1
Stoffers, D.A.2
Chevre, J.C.3
-
19
-
-
33947594129
-
Hyperactive Ras in developmental disorders and cancer
-
Schubbert S, Shannon K, Bollag G. Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer 2007; 7: 295-308.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 295-308
-
-
Schubbert, S.1
Shannon, K.2
Bollag, G.3
-
20
-
-
0035207991
-
Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4
-
Moore PS, Sipos B, Orlandini S, et al. Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4. Virchows Arch 2001; 439: 798-802.
-
(2001)
Virchows Arch
, vol.439
, pp. 798-802
-
-
Moore, P.S.1
Sipos, B.2
Orlandini, S.3
-
21
-
-
79958043820
-
Cetuximab in the treatment of patients with colorectal cancer
-
Garrett CR, Eng C. Cetuximab in the treatment of patients with colorectal cancer. Expert Opin Biol Ther 2011; 11: 937-949.
-
(2011)
Expert Opin Biol Ther
, vol.11
, pp. 937-949
-
-
Garrett, C.R.1
Eng, C.2
-
22
-
-
79955589454
-
Genetic diagnosis of pancreatic cancer using specimens obtained by EUS-FNA
-
Ryozawa S, Iwano H, Taba K, Sen-yo M, Uekitani T. Genetic diagnosis of pancreatic cancer using specimens obtained by EUS-FNA. Dig Endosc 2011; 23: 43-45.
-
(2011)
Dig Endosc
, vol.23
, pp. 43-45
-
-
Ryozawa, S.1
Iwano, H.2
Taba, K.3
Sen-Yo, M.4
Uekitani, T.5
-
23
-
-
77957150824
-
KRAS, Hedgehog, Wint and the twisted developmental biology of pancreatic ductal adenocarcinoma
-
Morris JP, Wang SC Hebrok M. KRAS, Hedgehog, Wint and the twisted developmental biology of pancreatic ductal adenocarcinoma. Nat Rev Cancer 2010; 10: 683-695.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 683-695
-
-
Morris, J.P.1
Wang, S.C.2
Hebrok, M.3
-
24
-
-
57449111916
-
Genetic and epigenetic alterations of familial pancreatic cancers
-
Brune K, Hong SM, Li A, et al. Genetic and epigenetic alterations of familial pancreatic cancers. Cancer Epidemiol Biomarkers Prev 2008; 17: 3536-3542.
-
(2008)
Cancer Epidemiol Biomarkers Prev
, vol.17
, pp. 3536-3542
-
-
Brune, K.1
Hong, S.M.2
Li, A.3
-
25
-
-
0141456482
-
Distinct K-ras mutation pattern characterizes signet ring cell colorectal carcinoma
-
Wistuba, II, Behrens C, Albores-Saavedra J, Delgado R, Lopez F, Gazdar AF. Distinct K-ras mutation pattern characterizes signet ring cell colorectal carcinoma. Clin Cancer Res 2003; 9: 3615-3619.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 3615-3619
-
-
Wistuba, I.I.1
Behrens, C.2
Albores-Saavedra, J.3
Delgado, R.4
Lopez, F.5
Gazdar, A.F.6
-
26
-
-
23044466047
-
Specificity and versatility in tgf-beta signaling through Smads
-
Feng XH, Derynck R. Specificity and versatility in tgf-beta signaling through Smads. Annu Rev Cell Dev Biol 2005; 21: 659-693.
-
(2005)
Annu Rev Cell Dev Biol
, vol.21
, pp. 659-693
-
-
Feng, X.H.1
Derynck, R.2
-
27
-
-
0032442852
-
Smads: Transcriptional activators of TGF-beta responses
-
Derynck R, Zhang Y, Feng XH. Smads: transcriptional activators of TGF-beta responses. Cell 1998; 95: 737-740.
-
(1998)
Cell
, vol.95
, pp. 737-740
-
-
Derynck, R.1
Zhang, Y.2
Feng, X.H.3
-
28
-
-
58149239730
-
Phospho-control of TGF-beta superfamily signaling
-
Wrighton KH, Lin X, Feng XH. Phospho-control of TGF-beta superfamily signaling. Cell Res 2009; 19: 8-20.
-
(2009)
Cell Res
, vol.19
, pp. 8-20
-
-
Wrighton, K.H.1
Lin, X.2
Feng, X.H.3
-
29
-
-
0037757793
-
Role of Smad4 (DPC4) inactivation in human cancer
-
Miyaki M, Kuroki T. Role of Smad4 (DPC4) inactivation in human cancer. Biochem Biophys Res Commun 2003; 306: 799-804.
-
(2003)
Biochem Biophys Res Commun
, vol.306
, pp. 799-804
-
-
Miyaki, M.1
Kuroki, T.2
-
30
-
-
79958741371
-
Aberrant TGFbeta/SMAD4 signaling contributes to epigeneticsilencing of a putative tumor suppressor, RunX1T1 in ovarian cancer
-
Yeh KT, Chen TH, Yang HW, et al. Aberrant TGFbeta/SMAD4 signaling contributes to epigeneticsilencing of a putative tumor suppressor, RunX1T1 in ovarian cancer. Epigenetics 2011; 6: 727-739.
-
(2011)
Epigenetics
, vol.6
, pp. 727-739
-
-
Yeh, K.T.1
Chen, T.H.2
Yang, H.W.3
-
31
-
-
84859741104
-
MicroRNA miR- 146b-5p regulates signal transduction of TGF-beta by repressing SMAD4 in thyroid cancer
-
Epub ahead of print
-
Geraldo MV, Yamashita AS, Kimura ET. MicroRNA miR- 146b-5p regulates signal transduction of TGF-beta by repressing SMAD4 in thyroid cancer. Oncogene 2011; [Epub ahead of print]
-
(2011)
Oncogene
-
-
Geraldo, M.V.1
Yamashita, A.S.2
Kimura, E.T.3
-
32
-
-
0142104985
-
Smad-dependent and Smadindependent pathways in TGF-beta family signalling
-
Derynck R, Zhang YE. Smad-dependent and Smadindependent pathways in TGF-beta family signalling. Nature 2003; 425: 577-584.
-
(2003)
Nature
, vol.425
, pp. 577-584
-
-
Derynck, R.1
Zhang, Y.E.2
-
33
-
-
1442352122
-
Tumor-derived C-terminal mutations of Smad4 with decreased DNA binding activity and enhanced intramolecular interaction
-
Kuang C, Chen Y. Tumor-derived C-terminal mutations of Smad4 with decreased DNA binding activity and enhanced intramolecular interaction. Oncogene 2004; 23: 1021-1029.
-
(2004)
Oncogene
, vol.23
, pp. 1021-1029
-
-
Kuang, C.1
Chen, Y.2
-
34
-
-
0033166440
-
Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus
-
Robertson KD, Jones PA. Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus. Oncogene 1999; 18: 3810-3820.
-
(1999)
Oncogene
, vol.18
, pp. 3810-3820
-
-
Robertson, K.D.1
Jones, P.A.2
-
35
-
-
0028059330
-
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
-
Caldas C, Hahn SA, da Costa LT, et al. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet 1994; 8: 27-32.
-
(1994)
Nat Genet
, vol.8
, pp. 27-32
-
-
Caldas, C.1
Hahn, S.A.2
da Costa, L.T.3
-
36
-
-
79952742260
-
Prevalence of CDKN2A mutations in pancreatic cancer patients: Implications for genetic counseling
-
McWilliams RR, Wieben ED, Rabe KG, et al. Prevalence of CDKN2A mutations in pancreatic cancer patients: implications for genetic counseling. Eur J Hum Genet 2011; 19: 472-478.
-
(2011)
Eur J Hum Genet
, vol.19
, pp. 472-478
-
-
McWilliams, R.R.1
Wieben, E.D.2
Rabe, K.G.3
-
37
-
-
0028308492
-
P53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions
-
Redston MS, Caldas C, Seymour AB, et al. p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions. Cancer Res 1994; 54: 3025-3033.
-
(1994)
Cancer Res
, vol.54
, pp. 3025-3033
-
-
Redston, M.S.1
Caldas, C.2
Seymour, A.B.3
-
38
-
-
0030907390
-
Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1
-
Sharma S, Jhala US, Johnson T, Ferreri K, Leonard J, Montminy M. Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1. Mol Cell Biol 1997; 17: 2598-2604.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 2598-2604
-
-
Sharma, S.1
Jhala, U.S.2
Johnson, T.3
Ferreri, K.4
Leonard, J.5
Montminy, M.6
-
39
-
-
0141787919
-
Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1
-
Schwitzgebel VM, Mamin A, Brun T, et al. Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1. J Clin Endocrinol Metab 2003; 88: 4398-4406.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 4398-4406
-
-
Schwitzgebel, V.M.1
Mamin, A.2
Brun, T.3
-
40
-
-
84863121044
-
Molecular characteristics of pancreatic ductal adenocarcinoma
-
article ID
-
Ottenhof NA, de Wilde RF, Maitra A, Hruban RH, Offerhaus GJ. Molecular characteristics of pancreatic ductal adenocarcinoma. Patholog Res Int 2011; 2011: 620601 (article ID).
-
(2011)
Patholog Res Int
, vol.2011
, pp. 620601
-
-
Ottenhof, N.A.1
de Wilde, R.F.2
Maitra, A.3
Hruban, R.H.4
Offerhaus, G.J.5
|