Effects of the mixture of Swertia pseudochmensis Hara and Silybum marianum Gaertn extracts on CCl4-induced liver injury in rats with non-alcoholic fatty liver disease

Journal of Chinese Integrative Medicine

Volumn 10, Issue 2, 2012, Pages 193-199

  Mao, Zhi Min ^a   Song, Hai Yan ^a   Yang, Li Li ^a   Liu, Tao ^a   Li, Dong Fei ^a   Zheng, Pei Yong ^a   Liu, Ping ^a   Ji, Guang ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Carbon tetrachloride; Fatty live; Liver injury; Non alcoholic; Oxidative stress; Plant extracts; Rats

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; GLUTATHIONE; MALONALDEHYDE; PLANT EXTRACT; SILYBUM MARIANUM EXTRACT; SWERTIA PSEUDOCHINENSIS EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; FATTY LIVER; HISTOPATHOLOGY; LIVER; LIVER INJURY; MALE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRIACYLGLYCEROL BLOOD LEVEL; WESTERN BLOTTING;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CARBON TETRACHLORIDE; DIET, HIGH-FAT; DRUG-INDUCED LIVER INJURY; DRUGS, CHINESE HERBAL; FATTY LIVER; GLUTATHIONE; LIVER; MALE; MALONDIALDEHYDE; MILK THISTLE; RATS; RATS, WISTAR; SWERTIA; TRIGLYCERIDES;

EID: 84863122942     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20120210     Document Type: Article

References (22)

1. The Chinese National Workshop on Fatty Liver and Alcoholic Liver Disease for the Chinese Liver Disease Association. Guidelines for management of nonalcoholic fatty liver disease: an updated and revised edition. Zhonghua Gan Zang Bing Za Zhi. 2010; 18(3): 163-166. Chinese.
2. Xie P, Zhou XX, Zhang Q. Pathogenesis and treatment of non-alcoholic fatty liver disease. J Chin Inter Med. 2010; 8(3): 201-209. Chinese with abstract in English.
3. Malik A, Cheah PL, Hilmi IN, Chan SP, Goh KL. Non-alcoholic fatty liver disease in Malaysia: a demographic, anthropometric, metabolic and histological study. J Dig Dis. 2007; 8(1): 58-64.
4. Donthamsetty S, Bhave VS, Mitra MS, Latendresse JR, Mehendale HM. Nonalcoholic fatty liver sensitizes rats to carbon tetrachloride hepatotoxicity. Hepatology. 2007; 45(2): 391-403.
5. Fan JG, Ding XD, Wang GL, Xu ZJ, Tian LY, Zheng XY. Expression of uncoupling protein 2 and its relationship to the content of adenosine triphosphate in the nonalcoholic fatty livers of rats fed a high-fat diet. Zhonghua Gan Zang Bing Za Zhi. 2005; 13(5): 374-377. Chinese with abstract in English.
6. Jiang XL, Zhang J, Liu SL, Wang GH. Oxidative stress and enzymatic antioxidant status in patients with hepatosteatosis. Sichuan Yi Xue. 2009; 30(12): 1958-1960. Chinese with abstract in English.
7. Singh R, Wang Y, Schattenberg JM, Xiang Y, Czaja MJ. Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation. Am J Physiol Gastrointest Liver Physiol. 2009; 297(5): G907-G917.
8. Adams LA, Lindor KD. Nonalcoholic fatty liver disease. Ann Epidemiol. 2007; 17(11): 863-869.
9. Krauss S, Zhang CY, Lowell BB. The mitochondrial uncoupling-protein homologues. Nat Rev Mol Cell Biol. 2005; 6(3): 248-261.
10. Wang W, Zhou JY. Uncoupling protein 2 and alcoholic liver disease. Guo Ji Nei Ke Xue Za Zhi. 2008; 35(5): 295-298. Chinese with abstract in English.
11. Ricquier D, Bouillaud F. Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance. J Physiol. 2000; 529 (Pt 1): 3-10.
12. Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, Levi-Meyrueis C, Bouillaud F, Seldin MF, Surwit RS, Ricquier D, Warden CH. Uncoupling protein-2: a novel gene linked to obesity and hyperinsu-linemia. Nat Genet. 1997; 15(3): 269-272.
13. Chan CB, Saleh MC, Koshkin V, Wheeler MB. Uncoupling protein 2 and islet function. Diabetes. 2004; 53 (Suppl 1): S136-S142.
14. Diehl AM, Hoek JB. Mitochondrial uncoupling: role of uncoupling protein anion carriers and relationship to thermogenesis and weight control "the benefits of losing contr?,'. J Bioenerg Biomembr. 1999; 31(5): 493-506.
15. Rashid A, Wu TC, Huang CC, Chen CH, Lin HZ, Yang SQ, Lee FY, Diehl AM. Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver. Hepatology. 1999; 29(4): 1131-1138.
16. Chavin KD, Yang SQ, Lin HZ, Chatham J, Chacko VP, Hoek JB, Walajtys-Rode E, Rashid A, Chen CH, Huang cc. Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion. J Biol Chem. 1999; 274(9): 5692-5700.
17. Zheng PY, Ma ZS, Liu T, Xing LJ, Ji G. Effect of Jiangzhi Granulas on serum leptin and liver leptin receptor mRNA of nonalcoholic fatty liver disease rat. Zhongguo Zhong Yi Yao Xin Xi Za Zhi. 2008; 15(6): 36-38. Chinese with abstract in Enlgish.
18. Ma ZS, Liu T, Zheng PY, Xing LJ, Ji G. Effect of Chinese medicine Jiangzhi Granula on hepatic lipid of nonalcoholic fatty liver disease rats. Zhonghua Zhong Yi Yao Xue Kan. 2007; 25 (5): 942-944. Chinese with abstract in English.
19. Zheng PY, Ma ZS, Hua YQ, Liu T, Xing LJ, Ji G. Effects of puerarin on expressions of leptin receptor mRNA, phosphorylated Janus kinase 2/phosphorylated signal transducers and activators of transcription 3 proteins in the liver of rats with non-alcoholic fatty liver. J Chin Inter Med. 2008; 6(9): 921-927. Chinese with abstract in English.
20. Zhou DC, Piao HS, Qin WJ, Ye ZG. Research progress of Swertia pseudochinensis Hara. Shizhen Guo Yi Guo Yao. 2011; 22(2): 462-465. Chinese.
21. Zhou DC, Piao HS, Zhang SY, Zhang GP. Protective effects of Swertia pseudochinensis Hara extract on experimental liver injury. Zhongguo Shi Yan Fang Ji Xue Za Zhi. 2010; 16(17): 125-128. Chinese with abstract in English.
22. Yu LC, Gu CH. Research progress of pharmacological effect of Silymarin. Zhongguo Yi Yuan Yao Xue Za Zhi. 2001; 21(8): 493-494. Chinese.