Acridine yellow G blocks glioblastoma growth via dual inhibition of epidermal growth factor receptor and protein kinase C kinases

Journal of Biological Chemistry

Volumn 287, Issue 9, 2012, Pages 6113-6127

  Qi, Qi ^a   He, Kunyan ^a   Yoo, Min Heui ^a   Chan, Chi Bun ^a   Liu, Xia ^a   Zhang, Zhaobin ^a   Olson, Jeffrey J ^a   Xiao, Ge ^b   Wang, Liya ^a   Mao, Hui ^a   Fu, Haian ^a   Tao, Hui ^a   Ramalingam, Suresh S ^a   Sun, Shi Yong ^a   Mischel, Paul S ^c   Ye, Keqiang ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN TUMORS; CELL-BASED; CELL-CYCLE ARREST; CONSTITUTIVELY ACTIVES; DELETION MUTANTS; EPIDERMAL GROWTH FACTOR RECEPTORS; GLIOBLASTOMAS; HUMAN CANCER; MALIGNANT GLIOMA; MAMMALIAN TARGET; ORAL ADMINISTRATION; PROOF OF CONCEPT; PROTEIN KINASE C; SMALL MOLECULES; THERAPEUTIC AGENTS;

CELL DEATH; CELL PROLIFERATION; DISEASES; TUMORS;

ENZYMES;

ACRIDINE DERIVATIVE; ACRIDINE YELLOW G; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; MAMMALIAN TARGET OF RAPAMYCIN; METHYLENE BLUE; PROTEIN KINASE C; TOLONIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; EMBRYO; ENZYME INHIBITION; FEMALE; GLIOBLASTOMA; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TUMOR VOLUME;

AMINOACRIDINES; ANIMALS; ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; G1 PHASE; GLIOBLASTOMA; HUMANS; MICE; MICE, NUDE; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MAMMALIA;

EID: 84863119515     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.293605     Document Type: Article

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