Mapping drug interactions at the covalent topoisomerase II-DNA complex by bisantrene/amsacrine congeners

Journal of Biological Chemistry

Volumn 273, Issue 21, 1998, Pages 12732-12739

  Capranico, Giovanni ^a   Guano, Fulvio ^a   Moro, Stefano ^b   Zagotto, Giuseppe ^b   Sissi, Claudia ^b   Gatto, Barbara ^b   Zunino, Franco ^a   Menta, Ernesto ^c   Palumbo, Manlio ^b  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c Boehringer Ingelheim Italia SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMSACRINE; ANTINEOPLASTIC AGENT; BISANTRENE; DIHYDRO 1H IMIDAZOL 2 YLHYDRAZONE; DNA TOPOISOMERASE (ATP HYDROLYSING); DRUG CARRIER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; DNA CLEAVAGE; DRUG CONFORMATION; DRUG DNA BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMSACRINE; ANTHRACENES; ANTINEOPLASTIC AGENTS; DNA; DNA TOPOISOMERASES, TYPE II; HYDROLYSIS; MAGNETIC RESONANCE SPECTROSCOPY; THERMODYNAMICS;

ANIMALIA;

EID: 0032557571     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.21.12732     Document Type: Article

References (29)

1. Palumbo, M. (1998) Advances in DNA Sequence-specific Agents 3, Jai Press Inc., Greenwhich, CT
2. Capranico, G., Binaschi, M., Borgnetto, M. E., Zunino, F., and Palumbo, M. (1997) Trends Pharmacol. Sci. 18, 303-346
3. Baguley, B. C. (1991) Anti-Cancer Drug Des. 6, 1-35
4. Bailly, C., Denny, W. A., and Waring, M. J. (1996) Anti-Cancer Drug Des. 11, 611-624
5. Pommier, Y. (1997) in Cancer Therapeutics: Experimental and Clinical Agents (Teicher, B. A., ed) pp. 153-174, Humana Press Inc., Totowa, NJ
6. Liu, L. F. (1989) Annu. Rev. Biochem. 58, 351-375
7. Froelich-Ammon, S. J., and Osheroff, N. (1995) J. Biol. Chem. 270, 21429-21432
8. Wang, J. C. (1996) Annu. Rev. Biochem. 65, 635-692
9. Watt, P. M., and Hickson, I. D. (1994) Biochem. J. 303, 681-695
10. Osheroff, N., Zechiedrich, E. L., and Gale, K. C. (1991) BioEssays 13, 269-273
11. Capranico, G., Kohn, K. W., and Pommier, Y. (1990) Nucleic Acids Res. 18, 6611-6619
12. Pommier, Y., Capranico, G., Orr, A., and Kohn, K. W. (1991) J. Mol. Biol. 222, 909-924
13. Freudenreich, C. H., and Kreuzer, K. N. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 11007-11011
14. Jaxel, C., Capranico, G., Kerrigan, D., Kohn, K. W., and Pommier, Y. (1991) J. Biol. Chem. 266, 20418-20423
15. Pommier, Y., Kohlhagen, G., Kohn, K. W., Leteurtre, F., Wani, M. C., and Wall, M. E. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 8861-8865
16. Macdonald, T. L., Lehnert, E. K., Loper, J. T., Chow, K.-C., and Ross, W. E. (1991) in DMA Topoisomerases in Cancer (Potmesil, M., and Kohn, K. W., eds) pp. 199-214, Oxford University Press, New York
17. Capranico, G., Palumbo, M., Tinelli, S., Mabilia, M., Pozzan, A., and Zunino, F. (1994) J. Mol. Biol. 235, 1218-1230
18. Zagotto, G., Oliva, A., Guano, F., Menta, E., Capranico, G., and Palumbo, M. (1998) Bioorg. & Med. Chem. Lett. 8, 121-126
19. De Isabella, P., Capranico, G., Binaschi, M., Tinelli, S., and Zunino, F. (1990) Mol. Pharmacol. 37, 11-16
20. Cornarotti, M., Tinelli, S., Willmore, E., Zunino, F., Fisher, L. M., Austin, C. A., and Capranico, G. (1996) Mol. Pharmacol. 50, 1463-1471
21. McGhee, J. D., and von Hippel, P. H. (1974) J. Mol. Biol. 86, 469-489
22. De Isabella, P., Zunino, F., and Capranico, G. (1995) Nucleic Acids Res. 23, 223-229
23. Pommier, V., Capranico, G., Orr, A., and Kohn, K. W. (1991) Nucleic Acids Res. 19, 5973-5980
24. Hehre, W. J., Radom, L., Schleyer, P. V. R., and Pople, J. A. (1986) Ab Initio Molecular Orbital Theory, John Wiley & Sons, New York
25. Martin, Y. C., Bures, M. G., and Willet, P. (1990) in Reviews in Computational Chemistry (Lipkowitz, K. B., and Boyd, D. B., eds) p. 213, VCH Publisher, Inc., New York
26. Dewar, M. J. S., Zoebisch, E. G., Healy, E. F., and Stewart, J. J. P. (1985) J. Am. Chem. Soc. 107, 3902-3910
27. Wunz, T. P., Craven, M. T., Karol, M. D., Hill, G. C., and Remers, W. A. (1990) J. Med. Chem. 33, 1549-1553
28. Chen, K.-X., Gresh, N., and Pullman, B. (1988) Nucleic Acids Res 16, 3061-3073
29. De Isabella, P., Palumbo, M., Sissi, C., Capranico, G., Carenini, N., Menta, E., Oliva, A., Spinelli, S., Krapcho, A. P., Giuliani, F. C., and Zunino, F. (1995) Mol. Pharmacol. 48, 30-38