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Volumn 454, Issue 7205, 2008, Pages 717-721

Secreted transcription factor controls Mycobacterium tuberculosis virulence

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; ESPR PROTEIN; TRANSCRIPTION FACTOR; VIRULENCE FACTOR;

EID: 49649095178     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature07219     Document Type: Article
Times cited : (162)

References (44)
  • 1
    • 0242268398 scopus 로고    scopus 로고
    • Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system
    • Stanley, S. A., Raghavan, S., Hwang, W. W. & Cox, J. S. Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system. Proc. Natl Acad. Sci. USA 100, 13001-13006 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 13001-13006
    • Stanley, S.A.1    Raghavan, S.2    Hwang, W.W.3    Cox, J.S.4
  • 2
    • 0142059794 scopus 로고    scopus 로고
    • The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue
    • Hsu, T. et al. The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue. Proc. Natl Acad. Sci. USA 100, 12420-12425 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 12420-12425
    • Hsu, T.1
  • 3
    • 34249012130 scopus 로고    scopus 로고
    • Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages
    • Pathak, S. K. et al. Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages. Nature Immunol. 8, 610-618 (2007).
    • (2007) Nature Immunol , vol.8 , pp. 610-618
    • Pathak, S.K.1
  • 4
    • 35348892037 scopus 로고    scopus 로고
    • Type VII secretion-mycobacteria show the way
    • Abdallah, A. M. et al. Type VII secretion-mycobacteria show the way. Nature Rev. Microbiol. 5, 883-891 (2007).
    • (2007) Nature Rev. Microbiol , vol.5 , pp. 883-891
    • Abdallah, A.M.1
  • 5
    • 0942290453 scopus 로고    scopus 로고
    • Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis
    • Guinn, K. M. et al. Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis. Mol. Microbiol. 51, 359-370 (2004).
    • (2004) Mol. Microbiol , vol.51 , pp. 359-370
    • Guinn, K.M.1
  • 6
    • 34249870368 scopus 로고    scopus 로고
    • A genetic screen for Mycobacterium tuberculosis mutants defective for phagosome maturation arrest identifies components of the ESX-1 secretion system
    • MacGurn, J. A. & Cox, J. S. A genetic screen for Mycobacterium tuberculosis mutants defective for phagosome maturation arrest identifies components of the ESX-1 secretion system. Infect. Immun. 75, 2668-2678 (2007).
    • (2007) Infect. Immun , vol.75 , pp. 2668-2678
    • MacGurn, J.A.1    Cox, J.S.2
  • 7
    • 14044254749 scopus 로고    scopus 로고
    • Tuberculous granuloma formation is enhanced by a mycobacterium virulence determinant
    • Volkman, H. E. et al. Tuberculous granuloma formation is enhanced by a mycobacterium virulence determinant. PLoS Biol. 2, e367 (2004).
    • (2004) PLoS Biol , vol.2
    • Volkman, H.E.1
  • 8
    • 33847359299 scopus 로고    scopus 로고
    • The Type I IFN response to infection with Mycobacterium tuberculosis requires ESX-1-mediated secretion and contributes to pathogenesis
    • Stanley, S. A., Johndrow, J. E., Manzanillo, P.&Cox, J. S. The Type I IFN response to infection with Mycobacterium tuberculosis requires ESX-1-mediated secretion and contributes to pathogenesis. J. Immunol. 178, 3143-3152 (2007).
    • (2007) J. Immunol , vol.178 , pp. 3143-3152
    • Stanley, S.A.1    Johndrow, J.E.2    Manzanillo, P.3    Cox, J.S.4
  • 9
    • 34547766513 scopus 로고    scopus 로고
    • ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membranelysing activity
    • de Jonge, M. I. et al. ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membranelysing activity. J. Bacteriol. 189, 6028-6034 (2007).
    • (2007) J. Bacteriol , vol.189 , pp. 6028-6034
    • de Jonge, M.I.1
  • 10
    • 0141539435 scopus 로고    scopus 로고
    • Intracellular expression of Mycobacterium tuberculosis-specific 10-kDa antigen down-regulates macrophage B7.1 expression and nitric oxide release
    • Singh, B., Singh, G., Trajkovic, V. & Sharma, P. Intracellular expression of Mycobacterium tuberculosis-specific 10-kDa antigen down-regulates macrophage B7.1 expression and nitric oxide release. Clin. Exp. Immunol. 134, 70-77 (2003).
    • (2003) Clin. Exp. Immunol , vol.134 , pp. 70-77
    • Singh, B.1    Singh, G.2    Trajkovic, V.3    Sharma, P.4
  • 12
    • 0033972623 scopus 로고    scopus 로고
    • MTSA-10, the product of the Rv3874 gene of Mycobacterium tuberculosis, elicits tuberculosis-specific, delayed-type hypersensitivity in guinea pigs
    • Colangeli, R. et al. MTSA-10, the product of the Rv3874 gene of Mycobacterium tuberculosis, elicits tuberculosis-specific, delayed-type hypersensitivity in guinea pigs. Infect. Immun. 68, 990-993 (2000).
    • (2000) Infect. Immun , vol.68 , pp. 990-993
    • Colangeli, R.1
  • 13
    • 0035873516 scopus 로고    scopus 로고
    • Vaccination with the T cell antigen Mtb 8.4 protects against challenge with Mycobacterium tuberculosis
    • Coler, R. N. et al. Vaccination with the T cell antigen Mtb 8.4 protects against challenge with Mycobacterium tuberculosis. J. Immunol. 166, 6227-6235 (2001).
    • (2001) J. Immunol , vol.166 , pp. 6227-6235
    • Coler, R.N.1
  • 14
    • 33750319222 scopus 로고    scopus 로고
    • Mucosal administration of Ag85B-ESAT-6 protects against infection with Mycobacterium tuberculosis and boosts prior bacillus Calmette-Guerin immunity
    • Dietrich, J. et al. Mucosal administration of Ag85B-ESAT-6 protects against infection with Mycobacterium tuberculosis and boosts prior bacillus Calmette-Guerin immunity. J. Immunol. 177, 6353-6360 (2006).
    • (2006) J. Immunol , vol.177 , pp. 6353-6360
    • Dietrich, J.1
  • 15
    • 33748047496 scopus 로고    scopus 로고
    • Envisioning future strategies for vaccination against tuberculosis
    • Kaufmann, S. H. Envisioning future strategies for vaccination against tuberculosis. Nature Rev. Immunol. 6, 699-704 (2006).
    • (2006) Nature Rev. Immunol , vol.6 , pp. 699-704
    • Kaufmann, S.H.1
  • 16
    • 0029920827 scopus 로고    scopus 로고
    • Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis
    • Mahairas, G. G., Sabo, P. J., Hickey, M. J., Singh, D. C. & Stover, C. K. Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis. J. Bacteriol. 178, 1274-1282 (1996).
    • (1996) J. Bacteriol , vol.178 , pp. 1274-1282
    • Mahairas, G.G.1    Sabo, P.J.2    Hickey, M.J.3    Singh, D.C.4    Stover, C.K.5
  • 17
    • 4644320227 scopus 로고    scopus 로고
    • A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion
    • Gao, L. Y. et al. A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion. Mol. Microbiol. 53, 1677-1693 (2004).
    • (2004) Mol. Microbiol , vol.53 , pp. 1677-1693
    • Gao, L.Y.1
  • 18
    • 14544279302 scopus 로고    scopus 로고
    • A protein secretion pathway critical for Mycobacterium tuberculosis virulence is conserved and functional in Mycobacterium smegmatis
    • Converse, S. E. & Cox, J. S. A protein secretion pathway critical for Mycobacterium tuberculosis virulence is conserved and functional in Mycobacterium smegmatis. J. Bacteriol. 187, 1238-1245 (2005).
    • (2005) J. Bacteriol , vol.187 , pp. 1238-1245
    • Converse, S.E.1    Cox, J.S.2
  • 19
    • 29644438456 scopus 로고    scopus 로고
    • Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence
    • Brodin, P. et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun. 74, 88-98 (2006).
    • (2006) Infect. Immun , vol.74 , pp. 88-98
    • Brodin, P.1
  • 20
    • 23044481526 scopus 로고    scopus 로고
    • Mutually dependent secretion of proteins required for mycobacterial virulence
    • Fortune, S. M. et al. Mutually dependent secretion of proteins required for mycobacterial virulence. Proc. Natl Acad. Sci. USA 102, 10676-10681 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 10676-10681
    • Fortune, S.M.1
  • 21
    • 25144441735 scopus 로고    scopus 로고
    • A non-RD1 gene cluster is required for Snm secretion in Mycobacterium tuberculosis
    • MacGurn, J. A., Raghavan, S., Stanley, S. A. & Cox, J. S. A non-RD1 gene cluster is required for Snm secretion in Mycobacterium tuberculosis. Mol. Microbiol. 57, 1653-1663 (2005).
    • (2005) Mol. Microbiol , vol.57 , pp. 1653-1663
    • MacGurn, J.A.1    Raghavan, S.2    Stanley, S.A.3    Cox, J.S.4
  • 22
    • 0034595501 scopus 로고    scopus 로고
    • Enhanced genome annotation using structural profiles in the program 3D-PSSM
    • Kelley, L. A., MacCallum, R. M. & Sternberg, M. J. Enhanced genome annotation using structural profiles in the program 3D-PSSM. J. Mol. Biol. 299, 499-520 (2000).
    • (2000) J. Mol. Biol , vol.299 , pp. 499-520
    • Kelley, L.A.1    MacCallum, R.M.2    Sternberg, M.J.3
  • 23
    • 0030070934 scopus 로고    scopus 로고
    • Crystallisation of the Bacillus subtilis sporulation inhibitor SinR, complexed with its antagonist, SinI
    • Lewis, R. J., Brannigan, J. A., Smith, I. & Wilkinson, A. J. Crystallisation of the Bacillus subtilis sporulation inhibitor SinR, complexed with its antagonist, SinI. FEBS Lett. 378, 98-100 (1996).
    • (1996) FEBS Lett , vol.378 , pp. 98-100
    • Lewis, R.J.1    Brannigan, J.A.2    Smith, I.3    Wilkinson, A.J.4
  • 24
    • 35848943478 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis invasion of macrophages: Linking bacterial gene expression to environmental cues
    • Rohde, K. H., Abramovitch, R. B. & Russell, D. G. Mycobacterium tuberculosis invasion of macrophages: Linking bacterial gene expression to environmental cues. Cell Host Microbe 2, 352-364 (2007).
    • (2007) Cell Host Microbe , vol.2 , pp. 352-364
    • Rohde, K.H.1    Abramovitch, R.B.2    Russell, D.G.3
  • 25
    • 33748776564 scopus 로고    scopus 로고
    • C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis
    • Champion, P. A., Stanley, S. A., Champion, M. M., Brown, E. J. & Cox, J. S. C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science 313, 1632-1636 (2006).
    • (2006) Science , vol.313 , pp. 1632-1636
    • Champion, P.A.1    Stanley, S.A.2    Champion, M.M.3    Brown, E.J.4    Cox, J.S.5
  • 26
    • 0027724892 scopus 로고
    • Sensing structural intermediates in bacterial flagellar assembly by export of a negative regulator
    • Hughes, K. T., Gillen, K. L., Semon, M. J. & Karlinsey, J. E. Sensing structural intermediates in bacterial flagellar assembly by export of a negative regulator. Science 262, 1277-1280 (1993).
    • (1993) Science , vol.262 , pp. 1277-1280
    • Hughes, K.T.1    Gillen, K.L.2    Semon, M.J.3    Karlinsey, J.E.4
  • 27
    • 20344403312 scopus 로고    scopus 로고
    • ExsE, a secreted regulator of type III secretion genes in Pseudomonas aeruginosa
    • Rietsch, A., Vallet-Gely, I., Dove, S. L. & Mekalanos, J. J. ExsE, a secreted regulator of type III secretion genes in Pseudomonas aeruginosa. Proc. Natl Acad. Sci. USA 102, 8006-8011 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 8006-8011
    • Rietsch, A.1    Vallet-Gely, I.2    Dove, S.L.3    Mekalanos, J.J.4
  • 28
    • 22244459205 scopus 로고    scopus 로고
    • A secreted regulatory protein couples transcription to the secretory activity of the Pseudomonas aeruginosa type III secretion system
    • Urbanowski, M. L., Lykken, G. L. & Yahr, T. L. A secreted regulatory protein couples transcription to the secretory activity of the Pseudomonas aeruginosa type III secretion system. Proc. Natl Acad. Sci. USA 102, 9930-9935 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 9930-9935
    • Urbanowski, M.L.1    Lykken, G.L.2    Yahr, T.L.3
  • 29
    • 20344407810 scopus 로고    scopus 로고
    • A secreted anti-activator, OspD1, and its chaperone, Spa15, are involved in the control of transcription by the type III secretion apparatus activity in Shigella flexneri
    • Parsot, C. et al. A secreted anti-activator, OspD1, and its chaperone, Spa15, are involved in the control of transcription by the type III secretion apparatus activity in Shigella flexneri. Mol. Microbiol. 56, 1627-1635 (2005).
    • (2005) Mol. Microbiol , vol.56 , pp. 1627-1635
    • Parsot, C.1
  • 30
    • 0027458469 scopus 로고
    • Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation
    • Ensoli, B. et al. Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation. J. Virol. 67, 277-287 (1993).
    • (1993) J. Virol , vol.67 , pp. 277-287
    • Ensoli, B.1
  • 31
    • 0036677811 scopus 로고    scopus 로고
    • Engrailed homeoprotein secretion is a regulated process
    • Maizel, A. et al. Engrailed homeoprotein secretion is a regulated process. Development 129, 3545-3553 (2002).
    • (2002) Development , vol.129 , pp. 3545-3553
    • Maizel, A.1
  • 32
    • 40349106159 scopus 로고    scopus 로고
    • Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP
    • Frigui, W. et al. Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP. PLoS Pathog. 4, e33 (2008).
    • (2008) PLoS Pathog , vol.4
    • Frigui, W.1
  • 33
    • 38849102911 scopus 로고    scopus 로고
    • Mutation in the transcriptional regulator PhoP contributes to avirulence of Mycobacterium tuberculosis H37Ra strain
    • Lee, J. S. et al. Mutation in the transcriptional regulator PhoP contributes to avirulence of Mycobacterium tuberculosis H37Ra strain. Cell Host Microbe 3, 97-103 (2008).
    • (2008) Cell Host Microbe , vol.3 , pp. 97-103
    • Lee, J.S.1
  • 34
    • 23244432880 scopus 로고    scopus 로고
    • Long-term control of Mycobacterium tuberculosis infection is mediated by dynamic immune responses
    • Lazarevic, V., Nolt, D. & Flynn, J. L. Long-term control of Mycobacterium tuberculosis infection is mediated by dynamic immune responses. J. Immunol. 175, 1107-1117 (2005).
    • (2005) J. Immunol , vol.175 , pp. 1107-1117
    • Lazarevic, V.1    Nolt, D.2    Flynn, J.L.3
  • 35
    • 34247588355 scopus 로고    scopus 로고
    • tuberculosis Ser/Thr protein kinase D phosphorylates an anti-anti-sigma factor homolog
    • Greenstein, A. E. et al. tuberculosis Ser/Thr protein kinase D phosphorylates an anti-anti-sigma factor homolog. PLoS Pathog. 3, e49 (2007).
    • (2007) PLoS Pathog , vol.3
    • Greenstein, A.E.1
  • 36
    • 0043142536 scopus 로고    scopus 로고
    • Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: Insights into the phagosomal environment
    • Schnappinger, D. et al. Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: Insights into the phagosomal environment. J. Exp. Med. 198, 693-704 (2003).
    • (2003) J. Exp. Med , vol.198 , pp. 693-704
    • Schnappinger, D.1
  • 37
    • 0242268398 scopus 로고    scopus 로고
    • Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system
    • Stanley, S. A., Raghavan, S., Hwang, W. W. & Cox, J. S. Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system. Proc. Natl Acad. Sci. USA 100, 13001-13006 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 13001-13006
    • Stanley, S.A.1    Raghavan, S.2    Hwang, W.W.3    Cox, J.S.4
  • 38
    • 25144441735 scopus 로고    scopus 로고
    • A non-RD1 gene cluster is required for Snm secretion in Mycobacterium tuberculosis
    • MacGurn, J. A., Raghavan, S., Stanley, S. A. & Cox, J. S. A non-RD1 gene cluster is required for Snm secretion in Mycobacterium tuberculosis. Mol. Microbiol. 57, 1653-1663 (2005).
    • (2005) Mol. Microbiol , vol.57 , pp. 1653-1663
    • MacGurn, J.A.1    Raghavan, S.2    Stanley, S.A.3    Cox, J.S.4
  • 39
    • 34247588355 scopus 로고    scopus 로고
    • tuberculosis Ser/Thr protein kinase D phosphorylates an anti-anti-sigma factor homolog
    • Greenstein, A. E. et al. tuberculosis Ser/Thr protein kinase D phosphorylates an anti-anti-sigma factor homolog. PLoS Pathog. 3, e49 (2007).
    • (2007) PLoS Pathog , vol.3
    • Greenstein, A.E.1
  • 40
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • Tusher, V. G., Tibshirani, R. & Chu, G. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl Acad. Sci. USA 98, 5116-5121 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 41
    • 0043142536 scopus 로고    scopus 로고
    • Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: Insights into the phagosomal environment
    • Schnappinger, D. et al. Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: Insights into the phagosomal environment. J. Exp. Med. 198, 693-704 (2003).
    • (2003) J. Exp. Med , vol.198 , pp. 693-704
    • Schnappinger, D.1
  • 42
    • 0031726240 scopus 로고    scopus 로고
    • An inducible expression system permitting the efficient purification of a recombinant antigen from Mycobacterium smegmatis
    • Triccas, J. A., Parish, T., Britton, W. J.&Gicquel, B. An inducible expression system permitting the efficient purification of a recombinant antigen from Mycobacterium smegmatis. FEMS Microbiol. Lett. 167, 151-156 (1998).
    • (1998) FEMS Microbiol. Lett , vol.167 , pp. 151-156
    • Triccas, J.A.1    Parish, T.2    Britton, W.J.3    Gicquel, B.4
  • 43
    • 0028079877 scopus 로고
    • Escherichia coli-mycobacteria shuttle vectors for operon and gene fusions to lacZ: The pJEM series
    • Timm, J., Lim, E. M. & Gicquel, B. Escherichia coli-mycobacteria shuttle vectors for operon and gene fusions to lacZ: The pJEM series. J. Bacteriol. 176, 6749-6753 (1994).
    • (1994) J. Bacteriol , vol.176 , pp. 6749-6753
    • Timm, J.1    Lim, E.M.2    Gicquel, B.3
  • 44
    • 19744383611 scopus 로고    scopus 로고
    • Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor
    • Ehrt, S. et al. Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor. Nucleic Acids Res. 33, e21 (2005).
    • (2005) Nucleic Acids Res , vol.33
    • Ehrt, S.1


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