C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis

Science

Volumn 313, Issue 5793, 2006, Pages 1632-1636

  DiGiuseppe Champion, Patricia A ^a,b   Stanley, Sarah A ^a,b   Champion, Matthew M ^c   Brown, Eric J ^b   Cox, Jeffery S ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c APPLIED BIOSYSTEMS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; CARBON; CELL CULTURE; CELLS; PROTEINS; YEAST;

ESK-1/SNM SYSTEM; MACROPHAGES; MYCOBACTERIUM TUBERCULOSIS; VIRULENCE;

BACTERIA;

BACTERIAL PROTEIN; EARLY SECRETED ANTIGEN 6; MEMBRANE PROTEIN; PROTEIN CFP 10; PROTEIN ESX 1; UBIQUITIN; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

BACTERIUM; MUTATION; PROTEIN; VIRULENCE; YEAST;

ARTICLE; BACTERIAL CELL; BACTERIAL VIRULENCE; CARBOXY TERMINAL SEQUENCE; CYTOSOL; HOST; MACROPHAGE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; YEAST;

AMINO ACID SEQUENCE; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; DIMERIZATION; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PROTEIN BINDING; PROTEIN SORTING SIGNALS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; TWO-HYBRID SYSTEM TECHNIQUES; UBIQUITIN; VIRULENCE FACTORS;

CORYNEBACTERINEAE; MYCOBACTERIUM TUBERCULOSIS;

EID: 33748776564     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1131167     Document Type: Article

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27. We thank H. Madhani and the Cox laboratory for the critical reading of this manuscript, and members of the Cox, A. Sil, and E. Brown laboratories for helpful discussion. This investigation was supported by NIH under Ruth L. Kirschstein National Research Service Award A10S1SS to P.A.C. This work was supported by NIH grants A163302 and A151667. J.S.C gratefully acknowledges the support of the Sandier Family Supporting Foundation and the W. M. Keck Foundation.