Inhibitory effect of astragalin on expression of lipopolysaccharideinduced inflammatory mediators through NF-κB in macrophages

Archives of Pharmacal Research

Volumn 34, Issue 12, 2011, Pages 2101-2107

  Kim, Mi Sun ^a   Kim, Sang Hyun ^a  

^a Kyungpook National University School of Medicine   (South Korea)

Author keywords

Astragalin; Flavonoid; Inflammation; Macrophages; Nitric oxide; Nuclear factor B

Indexed keywords

ASTRAGALIN; CHEMOKINE; CYCLOOXYGENASE 2; CYTOKINE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; QUERCETIN;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; EX VIVO STUDY; IN VITRO STUDY; INFLAMMATION; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROTEIN EXPRESSION;

ANIMALS; CELL LINE; CELL SURVIVAL; CYCLOOXYGENASE 2; GENE EXPRESSION REGULATION; INFLAMMATION MEDIATORS; KAEMPFEROLS; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED ICR; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II;

EID: 84863116303     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-011-1213-x     Document Type: Article

References (28)

1. Abad, M. J., Bessa, A. L., Ballarin, B., Aragon, O., Gonzales, E., and Bermejo, P., Anti-inflammatory activity of four Bolivian Baccharis species (Compositae). J. Ethnopharmacol., 103, 338-344 (2006). (Pubitemid 43143367)
2. Altinoz, M. A. and Korkmaz, R., NF-kappaB, macrophage migration inhibitory factor and cyclooxygenase-inhibitions as likely mechanisms behind the acetaminophenand NSAID-prevention of the ovarian cancer. Neoplasma, 51, 239-247 (2004). (Pubitemid 38915539)
3. Bitis, L., Kultur, S., Melikoglu, G., Ozsoy, N., and Can, A., Flavonoids and antioxidant activity of Rosa agrestis leaves. Nat. Prod. Res., 24, 580-589 (2010).
4. Cho, S. Y., Park, S. J., Kwon, M. J., Jeong, T. S., Bok, S. H., Choi, W. Y., Jeong, W. I., Ryu, S. Y., Do, S. H., Lee, C. S., Song, J. C., and Jeong, K. S., Quercetin suppresses proinflammatory cytokines production through MAP kinases and NF-kappaB pathway in lipopolysaccharide-stimulated macrophage. Mol. Cell. Biochem., 243, 153-160 (2003).
5. Eads, D., Hansen, R., Oyegunwa, A., Cecil, C., Culver, C., Scholle, F., Petty, I., and Laster, S., Terameprocol, a methylated derivative of nordihydroguaiaretic acid, inhibits production of prostaglandins and several key inflammatory cytokines and chemokines. J. Inflamm. (Lond), 6, 2 (2009).
6. Gross, S. S. and Wolin, M. S., Nitric oxide: pathophysiological mechanisms. Annu. Rev. Physiol., 57, 737-769 (1995).
7. Hamalainen, M., Nieminen, R., Vuorela, P., Heinonen, M., and Moilanen, E., Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators Inflamm., 2007, 45673 (2007).
8. Higa, S., Hirano, T., Kotani, M., Matsumoto, M., Fujita, A., Suemura, M., Kawase, I., and Tanaka, T., Fisetin, a flavonol, inhibits TH2-type cytokine production by activated human basophils. J. Allergy Clin. Immunol., 111, 1299-1306 (2003). (Pubitemid 36683686)
9. Hirano, T., Arimitsu, J., Higa, S., Naka, T., Ogata, A., Shima, Y., Fujimoto, M., Yamadori, T., Ohkawara, T., Kuwabara, Y., Kawai, M., Kawase, I., and Tanaka, T., Luteolin, a flavonoid, inhibits CD40 ligand expression by activated human basophils. Int. Arch. Allergy Immunol., 140, 150-156 (2006). (Pubitemid 43725809)
10. Inaba, H., Tagashira, M., Honma, D., Kanda, T., Kou, Y., Ohtake, Y., and Amano, A., Identification of hop polyphenolic components which inhibit prostaglandin E2 production by gingival epithelial cells stimulated with periodontal pathogen. Biol. Pharm. Bull., 31, 527-530 (2008). (Pubitemid 351442153)
11. Jung, C. H., Kim, J. H., Hong, M. H., Seog, H. M., Oh, S. H., Lee, P. J., Kim, G. J., Kim, H. M., Um, J. Y., and Ko, S. G., Phenolic-rich fraction from Rhus verniciflua Stokes (RVS) suppress inflammatory response via NF-kappaB and JNK pathway in lipopolysaccharide-induced RAW 264.7 macrophages. J. Ethnopharmacol., 110, 490-497 (2007). (Pubitemid 46386364)
12. Kameda, K., Takaku, T., Okuda, H., Kimura, Y., Okuda, T., Hatano, T., Agata, I., and Arichi, S., Inhibitory effects of various flavonoids isolated from leaves of persimmon on angiotensin-converting enzyme activity. J. Nat. Prod., 50, 680-683 (1987). (Pubitemid 18068610)
13. Kim, M. S., Park, S. B., Suk, K., Kim, I. K., Kim, S. Y., Kim, J. A., Lee, S. H., and Kim, S. H., Gallotannin isolated from Euphorbia species, 1,2,6-tri-O-galloyl-beta-D-allose, decreases nitric oxide production through inhibition of nuclear factor-kappa>B and downstream inducible nitric oxide synthase expression in macrophages. Biol. Pharm. Bull., 32, 1053-1056 (2009).
14. Kim, S. H., Johnson, V. J., and Sharma, R. P., Mercury inhibits nitric oxide production but activates proinflammatory cytokine expression in murine macrophage: differential modulation of NF-kappaB and p38 MAPK signaling pathways. Nitric Oxide, 7, 67-74 (2002). (Pubitemid 35007262)
15. Kim, S. H. and Sharma, R. P., Mercury-induced apoptosis and necrosis in murine macrophages: role of calciuminduced reactive oxygen species and p38 mitogen-activated protein kinase signaling. Toxicol. Appl. Pharmacol., 196, 47-57 (2004). (Pubitemid 38393693)
16. Kim, S. H., Jun, C. D., Suk, K., Choi, B. J., Lim, H., Park, S., Lee, S. H., Shin, H. Y., Kim, D. K., and Shin, T. Y., Gallic acid inhibits histamine release and pro-inflammatory cytokine production in mast cells. Toxicol. Sci., 91, 123-131 (2006).
17. Kim, S. H., Lee, S., Suk, K., Bark, H., Jun, C. D., Kim, D. K., Choi, C. H., and Yoshimura, T., Discoidin domain receptor 1 mediates collagen-induced nitric oxide production in J774A.1 murine macrophages. Free Radic. Biol. Med., 42, 343-352 (2007). (Pubitemid 46038041)
18. Kotani, M., Matsumoto, M., Fujita, A., Higa, S., Wang, W., Suemura, M., Kishimoto, T., and Tanaka, T., Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice. J. Allergy Clin. Immunol., 106, 159-166 (2000). (Pubitemid 30482866)
19. Lee, S., Suk, K., Kim, I. K., Jang, I. S., Park, J. W., Johnson, V. J., Kwon, T. K., Choi, B. J., and Kim, S. H., Signaling pathways of bisphenol A-induced apoptosis in hippocampal neuronal cells: role of calcium-induced reactive oxygen species, mitogen-activated protein kinases, and nuclear factor-kappaB. J. Neurosci. Res., 86, 2932-2942 (2008).
20. Lee, S. H., Soyoola, E., Chanmugam, P., Hart, S., Sun, W., Zhong, H., Liou, S., Simmons, D., and Hwang, D., Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J. Biol. Chem., 267, 25934-25938 (1992). (Pubitemid 23013998)
21. Liu, P. T. and Modlin, R. L., Human macrophage host defense against Mycobacterium tuberculosis. Curr. Opin. Immunol., 20, 371-376 (2008).
22. Maier, J. A., Hla, T., and Maciag, T., Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells. J. Biol. Chem., 265, 10805-10808 (1990).
23. Metcalfe, D. D., Baram, D., and Mekori, Y. A., Mast cells. Physiol. Rev., 77, 1033-1079 (1997). (Pubitemid 27459579)
24. Nhiem, N. X., Tai, B. H., Quang, T. H., Kiem, P. V., Minh, C. V., Nam, N. H., Kim, J. H., Im, L. R., Lee, Y. M., and Kim, Y. H., A new ursane-type triterpenoid glycoside from Centella asiatica leaves modulates the production of nitric oxide and secretion of TNF-alpha in activated RAW 264.7 cells. Bioorg. Med. Chem. Lett., 21, 1777-1781 (2011).
25. Park, H. H., Lee, S., Son, H. Y., Park, S. B., Kim, M. S., Choi, E. J., Singh, T. S., Ha, J. H., Lee, M. G., Kim, J. E., Hyun, M. C., Kwon, T. K., Kim, Y. H., and Kim, S. H., Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells. Arch. Pharm. Res., 31, 1303-1311 (2008).
26. Shen, S. C., Lee, W. R., Lin, H. Y., Huang, H. C., Ko, C. H., Yang, L. L., and Chen, Y. C., In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production. Eur. J. Pharmacol., 446, 187-194 (2002).
27. Xie, Q. W., Kashiwabara, Y., and Nathan, C., Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J. Biol. Chem., 269, 4705-4708 (1994). (Pubitemid 24239438)
28. Yasukawa, K., Takido, M., Takeuchi, M., Sato, Y., Nitta, K., and Nakagawa, S., Inhibitory effects of flavonol glycosides on 12-O- tetradecanoylphorbol-13-acetate-induced tumor promotion. Chem. Pharm. Bull. (Tokyo), 38, 774-776 (1990). (Pubitemid 20316816)