STAT5 isoforms regulate colorectal cancer cell apoptosis via reduction of mitochondrial membrane potential and generation of reactive oxygen species

Journal of Cellular Physiology

Volumn 227, Issue 6, 2012, Pages 2421-2429

  Du, Wan ^a   Wang, Ying Chao ^a   Hong, Jie ^a   Su, Wen Yu ^a   Lin, Yan Wei ^a   Lu, Rong ^a   Xiong, Hua ^a   Fang, Jing Yuan ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; ISOPROTEIN; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STAT5A PROTEIN; STAT5B PROTEIN;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER STAGING; CARCINOGENESIS; CELL CYCLE PROGRESSION; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; COLORECTAL NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MIDDLE AGED; NEOPLASM STAGING; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; STAT5 TRANSCRIPTION FACTOR; TIME FACTORS; TISSUE ARRAY ANALYSIS; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 84863115240     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22977     Document Type: Article

References (34)

1. Amorino GP, Hamilton VM, Valerie K, Dent P, Lammering G, Schmidt-Ullrich RK. 2002. Epidermal growth factor receptor dependence of radiation-induced transcription factor activation in human breast carcinoma cells. Mol Biol Cell 13: 2233-2244.
2. Berx G, Becker KF, Höfler H, van Roy F. 1998. Mutations of the human E-cadherin (CDH1) gene. Hum Mutat 12: 226-237.
3. Bowman T, Garcia R, Turkson J, Jove R. 2000. STATs in oncogenesis. Oncogene 19: 2474-2488.
4. Bromberg J, Darnell JE, Jr. 2000. The role of STATs in transcriptional control and their impact on cellular function. Oncogene 19: 2468-2473.
5. Buettner R, Mora LB, Jove R. 2002. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res 8: 945-954.
6. Buitenhuis M, Coffer PJ, Koenderman L. 2004. Signal transducer and activator of transcription 5 (STAT5). Int J Biochem Cell Biol 36: 2120-2124.
7. Coffer PJ, Koenderman L, de Groot RP. 2000. The role of STATs in myeloid differentiation and leukemia. Oncogene 19: 2511-2522.
8. Cui Y, Riedlinger G, Miyoshi K, Tang W, Li C, Deng CX, Robinson GW, Hennighausen L. 2004. Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol 24: 8037-8047.
9. Davey HW, Park SH, Grattan DR, McLachlan MJ, Waxman DJ. 1999. STAT5b-deficient mice are growth hormone pulse-resistant. Role of STAT5b in sex-specific liver p450 expression. J Biol Chem 274: 35331-35336.
10. Ghibelli L, Coppola S, Rotilio G, Lafavia E, Maresca V, Ciriolo MR. 1995. Non-oxidative loss of glutathione in apoptosis via GSH extrusion. Biochem Biophys Res Commun 216: 313-320.
11. Imada K, Bloom ET, Nakajima H, Horvath-Arcidiacono JA, Udy GB, Davey HW, Leonard WJ. 1998. Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity. J Exp Med 188: 2067-2074.
12. Klejman A, Schreiner SJ, Nieborowska-Skorska M, Slupianek A, Wilson M, Smithgall TE, Skorski T. 2002. The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells. EMBO J 21: 5766-5774.
13. Lee SW, Ko YG, Bang S, Kim KS, Kim S. 2000. Death effector domain of a mammalian apoptosis mediator, FADD, induces bacterial cell death. Mol Microbiol 35: 1540-1549.
14. Lehmann U, Schmitz J, Weissenbach M, Sobota RM, Hortner M, Friederichs K, Behrmann I, Tsiaris W, Sasaki A, Schneider-Mergener J, Yoshimura A, Neel BG, Heinrich PC, Schaper F. 2003. SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. J Biol Chem 278: 661-671.
15. Li H, Ahonen TJ, Alanen K, Xie J, LeBaron MJ, Pretlow TG, Ealley EL, Zhang Y, Nurmi M, Singh B, Martikainen PM, Nevalainen MT. 2004. Activation of signal transducer and activator of transcription 5 in human prostate cancer is associated with high histological grade. Cancer Res 64: 4774-4782.
16. Li H, Zhang Y, Glass A, Zellweger T, Gehan E, Bubendorf L, Gelmann EP, Nevalainen MT. 2005. Activation of signal transducer and activator of transcription-5 in prostate cancer predicts early recurrence. Clin Cancer Res 11: 5863-5868.
17. Lilly M, Sandholm J, Cooper JJ, Koskinen PJ, Kraft A. 1999. The PIM-1 serine kinase prolongs survival and inhibits apoptosis-related mitochondrial dysfunction in part through a bcl-2-dependent pathway. Oncogene 18: 4022-4031.
18. Liu X, Robinson GW, Gouilleux F, Groner B, Hennighausen L. 1995. Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Proc Natl Acad Sci USA 92: 8831-8835.
19. Liu X, Robinson GW, Wagner KU, Garrett L, Wynshaw-Boris A, Hennighausen L. 1997. Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev 11: 179-186.
20. Lu R, Wang X, Chen ZF, Sun DF, Tian XQ, Fang JY. 2007. Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decreases DNA methylation in colon cancer cells. J Biol Chem 282: 12249-12259.
21. Morita Y, Naka T, Kawazoe Y, Fujimoto M, Narazaki M, Nakagawa R, Fukuyama H, Nagata S, Kishimoto T. 2000. Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts. Proc Natl Acad Sci USA 97: 5405-5410.
22. Nakajima H, Liu XW, Wynshaw-Boris A, Rosenthal LA, Imada K, Finbloom DS, Hennighausen L, Leonard WJ. 1997. An indirect effect of Stat5a in IL-2-induced proliferation: A critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction. Immunity 7: 691-701.
23. Nevalainen MT, Xie J, Torhorst J, Bubendorf L, Haas P, Kononen J, Sauter G, Rui H. 2004. Signal transducer and activator of transcription-5 activation and breast cancer prognosis. J Clin Oncol 22: 2053-2060.
24. Teglund S, McKay C, Schuetz E, van Deursen JM, Stravopodis D, Wang D, Brown M, Bodner S, Grosveld G, Ihle JN. 1998. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 93: 841-850.
25. Tinhofer I, Bernhard D, Senfter M, Anether G, Loeffler M, Kroemer G, Kofler R, Csordas A, Greil R. 2001. Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2. FASEB J 15: 1613-1615.
26. Udy GB, Towers RP, Snell RG, Wilkins RJ, Park SH, Ram PA, Waxman DJ, Davey HW. 1997. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc Natl Acad Sci USA 94: 7239-7244.
27. Wang YY, Zhou GB, Yin T, Chen B, Shi JY, Liang WX, Jin XL, You JH, Yang G, Shen ZX, Chen J, Xiong SM, Chen GQ, Xu F, Liu YW, Chen Z, Chen SJ. 2005. AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: Implication in stepwise leukemogenesis and response to Gleevec. Proc Natl Acad Sci USA 102: 1104-1109.
28. Wang Z, Tang X, Li Y, Leu C, Guo L, Zheng X, Zhu D. 2008. 20-Hydroxyeicosatetraenoic acid inhibits the apoptotic responses in pulmonary artery smooth muscle cells. Eur J Pharmacol 588: 9-17.
29. Xi S, Zhang Q, Dyer KF, Lerner EC, Smithgall TE, Gooding WE, Kamens J, Grandis JR. 2003a. Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck. J Biol Chem 278: 31574-31583.
30. Xi S, Zhang Q, Gooding WE, Smithgall TE, Grandis JR. 2003b. Constitutive activation of Stat5b contributes to carcinogenesis in vivo. Cancer Res 63: 6763-6771.
31. Xiong H, Zhang ZG, Tian XQ, Sun DF, Liang QC, Zhang YJ, Lu R, Chen YX, Fang JY. 2008. Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells. Neoplasia 10: 287-297.
32. Xiong H, Su WY, Liang QC, Zhang ZG, Chen HM, Du W, Chen YX, Fang JY. 2009. Inhibition of STAT5 induces G1 cell cycle arrest and reduces tumor cell invasion in human colorectal cancer cells. Lab Invest 89: 717-725.
33. Yamabuki T, Takano A, Hayama S, Ishikawa N, Kato T, Miyamoto M, Ito T, Ito H, Miyagi Y, Nakayama H, Fujita M, Hosokawa M, Tsuchiya E, Kohno N, Kondo S, Nakamura Y, Daigo Y. 2007. Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas. Cancer Res 67: 2517-2525.
34. Ying W. 2008. NAD+/NADH and NADP+/NADPH in cellular functions and cell death: Regulation and biological consequences. Antioxid Redox Signal 10: 179-206.