C-Fos expression reveals aberrant neural network activity during cued fear conditioning in APPswe transgenic mice

Neurobiology of Learning and Memory

Volumn 98, Issue 1, 2012, Pages 1-11

  Lelos, Mariah J ^a   Good, Mark A ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Amygdala; Amyloid; C Fos; Fear; Hippocampus; Tg2576

Indexed keywords

AMYLOID PRECURSOR PROTEIN; PROTEIN C FOS;

AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONDITIONING; CONTROLLED STUDY; DENTATE GYRUS; GENE MUTATION; GENOTYPE; HABITUATION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MOUSE; NERVE CELL NETWORK; NONHUMAN; ONCOGENE C FOS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; TRANSGENIC MOUSE;

AMYGDALA; ANIMALS; BEHAVIOR, ANIMAL; CONDITIONING (PSYCHOLOGY); FEAR; HIPPOCAMPUS; MALE; MICE; MICE, TRANSGENIC; MOTOR ACTIVITY; NERVE NET; PROTO-ONCOGENE PROTEINS C-FOS;

EID: 84863110762     PISSN: 10747427     EISSN: 10959564     Source Type: Journal    
DOI: 10.1016/j.nlm.2012.03.001     Document Type: Article

References (50)

1. Albasser M.M., Poirier G.L., Aggleton J.P. Qualitatively different modes of perirhinal-hippocampal engagement when rats explore novel vs. familiar objects as revealed by c-Fos imaging. European Journal of Neuroscience 2010, 31:134-147.
2. Badowska-Szalewska E., Klejbor I., Dziwiatkowski J., Spodnik J.H., Morys J. The influence of acute and chronic open-field exposure on the hippocampal formation: An immunohistochemical study. Folia Morphol (Warsz) 2006, 65:343-351.
3. Barnes P., Good M. Impaired Pavlovian cued fear conditioning in Tg2576 mice expressing a human mutant amyloid precursor protein gene. Behavioural Brain Research 2005, 157:107-117.
4. Barnes J., Whitwell J.L., Frost C., Josephs K.A., Rossor M., Fox N.C. Measurements of the amygdala and hippocampus in pathologically confirmed Alzheimer disease and frontotemporal lobar degeneration. Archives of Neurology 2006, 63:1434-1439.
5. Basso M., Yang J., Warren L., MacAvoy M.G., Varma P., Bronen R.A., van Dyck C.H. Volumetry of amygdala and hippocampus and memory performance in Alzheimer's disease. Psychiatry Research 2006, 146:251-261.
6. Causal models in the social sciences 1985, Aldine de Gruyter, New York. 2nd ed. H.M. Blalock, H.M. Blalock (Eds.).
7. Boucard A., Marchand A., Nogues X. Reliability and validity of structural equation modeling applied to neuroimaging data: a simulation study. Journal of Neuroscience Methods 2007, 166:278-292.
8. Buchel C., Dolan R.J. Classical fear conditioning in functional neuroimaging. Current Opinion in Neurobiology 2000, 10:219-223.
9. Campeau S., Hayward M.D., Hope B.T., Rosen J.B., Nestler E.J., Davis M. Induction of the c-fos proto-oncogene in rat amygdala during unconditioned and conditioned fear. Brain Research 1991, 565:349-352.
10. Chapman P.F., White G.L., Jones M.W., Cooper-Blacketer D., Marshall V.J., Irizarry M., Younkin L., Good M.A., Bliss T.V., Hyman B.T., Younkin S.G., Hsiao K.K. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nature Neuroscience 1999, 2:271-276.
11. Chen Y., Fenoglio K.A., Dube C.M., Grigoriadis D.E., Baram T.Z. Cellular and molecular mechanisms of hippocampal activation by acute stress are age-dependent. Molecular Psychiatry 2006, 11:992-1002.
12. Comery T.A., Martone R.L., Aschmies S., Atchison K.P., Diamantidis G., Gong X., Zhou H., Kreft A.F., Pangalos M.N., Sonnenberg-Reines J., Jacobsen J.S., Marquis K.L. Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease. Journal of Neuroscience 2005, 25:8898-8902.
13. Corcoran K.A., Lu Y., Turner R.S., Maren S. Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease. Learning and Memory 2002, 9:243-252.
14. Dunsmoor J.E., Bandettini P.A., Knight D.C. Impact of continuous versus intermittent CS-UCS pairing on human brain activation during Pavlovian fear conditioning. Behavioral Neuroscience 2007, 121:635-642.
15. Fan, X., Wang, L., & Thompson, B. (1996). The effects of sample size, estimation methods, and model misspecification on SEM fit indices. Paper presented at the 1996 annual meeting of American Educational Research Association. New York, NY, April 8-12, Session #16.52.
16. Fanselow M.S. Conditioned and unconditional components of post-shock freezing. Pavlovian Journal of Biological Science 1980, 15:177-182.
17. Hamann S., Monarch E.S., Goldstein F.C. Impaired fear conditioning in Alzheimer's disease. Neuropsychologia 2002, 40:1187-1195.
18. Hoefer M., Allison S.C., Schauer G.F., Neuhaus J.M., Hall J., Dang J.N., Weiner M.W., Miller B.L., Rosen H.J. Fear conditioning in frontotemporal lobar degeneration and Alzheimer's disease. Brain 2008, 131:1646-1657.
19. Hu L.T., Bentler P.M. Fit indices in covariance structure modeling: sensitivity to underparameterized model misspecification. Psychological Methods 1998, 3:424-453.
20. Imbimbo B.P., Giardino L., Sivilia S., Giuliani A., Gusciglio M., Pietrini V., Del Giudice E., D'Arrigo A., Leon A., Villetti G., Calza L. CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer's disease. Journal of Alzheimers Disease 2010, 20:159-173.
21. Jacobsen J.S., Wu C.C., Redwine J.M., Comery T.A., Arias R., Bowlby M., Martone R., Morrison J.H., Pangalos M.N., Reinhart P.H., Bloom F.E. Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America 2006, 103:5161-5166.
22. Kalynchuk L.E., Davis A.C., Gregus A., Taggart J., Chris Dodd C., Wintink A.J., Marchant E.G. Hippocampal involvement in the expression of kindling-induced fear in rats. Neuroscience and Biobehavioral Reviews 2001, 25:687-696.
23. Kelloway E.K. Using LISREL for Structural Equation Modelling: A Researcher's Guide 1998, Sage Publications, London.
24. Kim M., Davis M. Electrolytic lesions of the amygdala block acquisition and expression of fear-potentiated startle even with extensive training but do not prevent reacquisition. Behavioral Neuroscience 1993, 107:580-595.
25. Kim J.J., Jung M.W. Neural circuits and mechanisms involved in Pavlovian fear conditioning: a critical review. Neuroscience and Biobehavioral Reviews 2006, 30:188-202.
26. Knafo S., Venero C., Merino-Serrais P., Fernaud-Espinosa I., Gonzalez-Soriano J., Ferrer I., Santpere G., DeFelipe J. Morphological alterations to neurons of the amygdala and impaired fear conditioning in a transgenic mouse model of Alzheimer's disease. Journal of Pathology 2009, 219:41-51.
27. Lehner M., Wislowska-Stanek A., Taracha E., Maciejak P., Szyndler J., Skorzewska A., Turzynska D., Sobolewska A., Hamed A., Bidzinski A., Plaznik A. The expression of c-Fos and colocalisation of c-Fos and glucocorticoid receptors in brain structures of low and high anxiety rats subjected to extinction trials and re-learning of a conditioned fear response. Neurobiology of Learning and Memory 2009, 92:535-543.
28. Lelos M.J., Thomas R.S., Kidd E.J., Good M.A. Outcome-specific satiety reveals a deficit in context-outcome, but not stimulus- or action-outcome, associations in aged Tg2576 mice. Behavioral Neuroscience 2011, 125:412-425.
29. Majak K., Pitkanen A. Activation of the amygdalo-entorhinal pathway in fear-conditioning in rat. European Journal of Neuroscience 2003, 18:1652-1659.
30. Maren S. Neurotoxic or electrolytic lesions of the ventral subiculum produce deficits in the acquisition and expression of Pavlovian fear conditioning in rats. Behavioral Neuroscience 1999, 113:283-290.
31. Maren S. Pavlovian fear conditioning as a behavioral assay for hippocampus and amygdala function: cautions and caveats. European Journal of Neuroscience 2008, 28:1661-1666.
32. Maren S., Holt W.G. Hippocampus and Pavlovian fear conditioning in rats: muscimol infusions into the ventral, but not dorsal, hippocampus impair the acquisition of conditional freezing to an auditory conditional stimulus. Behavioral Neuroscience 2004, 118:97-110.
33. Markesbery W.R., Schmitt F.A., Kryscio R.J., Davis D.G., Smith C.D., Wekstein D.R. Neuropathologic substrate of mild cognitive impairment. Archives of Neurology 2006, 63:38-46.
34. Masliah E., Mallory M., Hansen L., DeTeresa R., Alford M., Terry R. Synaptic and neuritic alterations during the progression of Alzheimer's disease. Neuroscience Letters 1994, 174:67-72.
35. McIntosh A.R., Gonzalez-Lima F. Structural modeling of functional neural pathways mapped with 2-deoxyglucose: effects of acoustic startle habituation on the auditory system. Brain Research 1991, 547:295-302.
36. McNally G.P., Johansen J.P., Blair H.T. Placing prediction into the fear circuit. Trends in Neurosciences 2011, 34:283-292.
37. Milanovic S., Radulovic J., Laban O., Stiedl O., Henn F., Spiess J. Production of the Fos protein after contextual fear conditioning of C57BL/6N mice. Brain Research 1998, 784:37-47.
38. Paxinos G., Franklin K.B.J. The mouse brain in stereotaxic coordinates 2001, Academic Press, London. 2nd ed.
39. Pedersen W.A., McMillan P.J., Kulstad J.J., Leverenz J.B., Craft S., Haynatzki G.R. Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice. Experimental Neurology 2006, 199:265-273.
40. Perez-Cruz C., Nolte M.W., van Gaalen M.M., Rustay N.R., Termont A., Tanghe A., Kirchhoff F., Ebert U. Reduced spine density in specific regions of CA1 pyramidal neurons in two transgenic mouse models of Alzheimer's disease. Journal of Neuroscience 2011, 31:3926-3934.
41. Quinn J.F., Bussiere J.R., Hammond R.S., Montine T.J., Henson E., Jones R.E., Stackman R.W. Chronic dietary alpha-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice. Neurobiology of Aging 2007, 28:213-225.
42. Richmond M.A., Yee B.K., Pouzet B., Veenman L., Rawlins J.N., Feldon J., Bannerman D.M. Dissociating context and space within the hippocampus: effects of complete, dorsal, and ventral excitotoxic hippocampal lesions on conditioned freezing and spatial learning. Behavioral Neuroscience 1999, 113:1189-1203.
43. Sanders M.J., Wiltgen B.J., Fanselow M.S. The place of the hippocampus in fear conditioning. European Journal of Pharmacology 2003, 463:217-223.
44. Scheff S.W., Price D.A. Alzheimer's disease-related alterations in synaptic density: neocortex and hippocampus. Journal of Alzheimers Disease 2006, 9:101-115.
45. Scheff S.W., Price D.A., Schmitt F.A., Scheff M.A., Mufson E.J. Synaptic loss in the inferior temporal gyrus in mild cognitive impairment and Alzheimer's disease. Journal of Alzheimers Disease 2011, 24:547-557.
46. Sierra-Mercado D., Padilla-Coreano N., Quirk G.J. Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear. Neuropsychopharmacology 2011, 36:529-538.
47. Steiger J.H. Structural model evaluation and modification: An interval estimationapproach. Multivariate Behavioral Research 1990, 25:173-180.
48. Swank M.W., Ellis A.E., Cochran B.N. C-Fos antisense blocks acquisition and extinction of conditioned taste aversion in mice. NeuroReport 1996, 7:1866-1870.
49. Tabachnik B.G., Fidell L.S. Using multivariate statistics 1996, Harper Collins, New York. 3rd ed.
50. Weitemier A.Z., Ryabinin A.E. Subregion-specific differences in hippocampal activity between delay and trace fear conditioning: An immunohistochemical analysis. Brain Research 2004, 995:55-65.