Neurotoxic or electrolytic lesions of the ventral subiculum produce deficits in the acquisition and expression of Pavlovian fear conditioning in rats

Behavioral Neuroscience

Volumn 113, Issue 2, 1999, Pages 283-290

  Maren, Stephen ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX LESION; CONDITIONING; CONTROLLED STUDY; ELECTROLYSIS; FEAR; MALE; MOTOR ACTIVITY; NEUROTOXICITY; NONHUMAN; RAT; SHOCK; SUBICULUM;

ANIMALS; AVOIDANCE LEARNING; CONDITIONING, CLASSICAL; FEAR; HIPPOCAMPUS; MALE; MOTOR ACTIVITY; NERVE NET; RATS; RATS, LONG-EVANS;

EID: 0032921394     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/0735-7044.113.2.283     Document Type: Article

References (35)

1. Blanchard, D. C., Blanchard, R. J., Lee, E. M. C., & Fukunaga, K. K. (1977). Movement arrest and the hippocampus. Physiological Psychology, 5, 331-335.
2. Burns, L. H., Annett, L., Kelley, A. E., Everitt, B. J., & Robbins, T. W. (1996). Effects of lesions to amygdala, ventral subiculum, medial prefrontal cortex, and nucleus accumbens on the reaction to novelty: Implication for limbic-striatal interactions. Behavioral Neuroscience, 110, 60-73.
3. Campeau, S., & Davis, M. (1995a). Involvement of the central nucleus and basolateral complex of the amygdala in fear conditioning measured with fear-potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli. Journal of Neuroscience, 15, 2301-2311.
4. Campeau, S., & Davis, M. (1995b). Involvement of subcortical and cortical afferents to the lateral nucleus of the amygdala in fear conditioning measured with fear-potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli. Journal of Neuroscience, 15, 2312-2327.
5. Canteras, N. S., & Swanson, L. W. (1992). Projections of the ventral subiculum to the amygdala, septum, and hypothalamus: A PHAL anterograde tract-tracing study in the rat. Journal of Comparative Neurology, 324, 180-194.
6. Corodimas, K. P., & LeDoux, J. E. (1995). Disruptive effects of posttraining perirhinal cortex lesions on conditioned fear: Contributions of contextual cues. Behavioral Neuroscience 109 613-619.
7. Davis, M., Rainnie, D., & Cassell, M. (1994). Neurotransmission in the rat amygdala related to fear and anxiety. Trends in Neurosciences, 17, 208-214.
8. Douglas, R. J., & Isaacson, R. L. (1964). Hippocampal lesions and activity. Psychonomic Science, 1, 187-188.
9. Fanselow, M. S. (1994). Neural organization of the defensive behavior system responsible for fear. Psychonomic Bulletin & Review, 1, 429-438.
10. Floresco, S. B., Seamans, J. K., & Phillips, A. G. (1997). Selective roles for hippocampal, prefrontal cortical, and ventral striatal circuits in radial-arm maze tasks with or without a delay. Journal of Neuroscience, 17, 1880-1890.
11. Frankland, P. W., Cestari, V., Filipkowski, R. K., McDonald, R. J., & Silva, A. J. (1998). The dorsal hippocampus is essential for context discrimination but not for contextual conditioning. Behavioral Neuroscience, 112, 863-874.
12. Helmstetter, F. J. (1992). The amygdala is essential for the expression of conditional hypoalgesia. Behavioral Neuroscience, 106, 518-528.
13. Kiernan, M. J., Bailey, G., Sims, J., Lukes, D., & Cranney, J. (1996). Accumbal lesions attenuate contextual fear conditioning in the rat. Society for Neuroscience Abstracts, 22, 1381.
14. Kim, J. J., & Fanselow, M. S. (1992). Modality-specific retrograde amnesia of fear. Science, 256, 675-677.
15. Maren, S. (1996). Synaptic transmission and plasticity in the amygdala: An emerging physiology of fear conditioning circuits. Molecular Neurobiology, 13, 1-22.
16. Maren, S. (1998). Overtraining does not mitigate contextual fear conditioning deficits produced by neurotoxic lesions of the basolateral amygdala. Journal of Neuroscience, 18, 3088-3097.
17. Maren, S., Aharonov, G., & Fanselow, M. S. (1996). Retrograde abolition of conditional fear after excitotoxic lesions in the basolateral amygdala of rats: Absence of a temporal gradient. Behavioral Neuroscience, 110, 718-726.
18. Maren, S., Aharonov, G., & Fanselow, M. S. (1997). Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats. Behavioural Brain Research, 88, 261-274.
19. Maren, S., Anagnostaras, S. G., & Fanselow, M. S. (1998). The startled seahorse: Is the hippocampus necessary for contextual fear conditioning? Trends in Cognitive Sciences, 2, 39-42.
20. Maren, S., & Fanselow, M. S. (1995). Synaptic plasticity in the basolateral amygdala induced by hippocampal formation stimulation in vivo. Journal of Neuroscience, 15, 7548-7564.
21. Maren, S., & Fanselow, M. S. (1996). The amygdala and fear conditioning: Has the nut been cracked? Neuron, 16, 237-240.
22. Maren, S., & Fanselow, M. S. (1997). Electrolytic lesions of the dorsal hippocampus, fimbria/fornix, or entorhinal cortex produce anterograde deficits in contextual fear conditioning in rats. Neurobiology of Learning and Memory, 67, 142-149.
23. McNish, K. A., Gewiritz, J. C., & Davis, M. (1997). Evidence of contextual fear after lesions of the hippocampus: A disruption of freezing but not fear potentiated startle. Journal of Neuroscience, 17, 9353-9360.
24. Milner, B., Squire, L. R., & Kandel, E. R. (1998). Cognitive neuroscience and the study of memory. Neuron, 20, 445-468.
25. Mitchell, D., Maren, S., & Hwang, R. (1993). The effects of hippocampal lesions on two neotic choice tasks. Psychobiology, 21, 193-202.
26. Morris, R. G. M., Garrud, P., Rawlins, J. N., & O'Keefe, J. (1982). Place navigation impaired in rats with hippocampal lesions. Nature, 297, 681-683.
27. Phillips, R. G., & LeDoux, J. E. (1992). Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behavioral Neuroscience, 106, 274-285.
28. Phillips, R. G., & LeDoux, J. E. (1995). Lesions of the fornix but not the entorhinal or perirhinal cortex interfere with contextual fear conditioning. Journal of Neuroscience, 15, 5308-5315.
29. Riedel, G., Harrington, N. R., Hall, G., Macphail, E. M. (1997). Nucleus accumbens lesions impair context, but not cue, conditioning in rats. Neuroreport, 8, 2477-2481.
30. Rogan, M., & LeDoux, J. E. (1996). Emotion: Systems, cells, synaptic plasticity. Cell, 85, 469-475.
31. Rosen, J. B., Hitchcock, J. M., Miserendino, M. J. D., Falls, W. A., Campeau, S., & Davis, M. (1992). Lesions of the perirhinal cortex but not of the frontal, medial, prefrontal, visual, or insular cortex block fear-potentiated startle using a visual conditioned stimulus. Journal of Neuroscience, 12, 4624-4633.
32. Selden, N. R., Everitt, B. J., Jarrard, L. E., & Robbins, T. W. (1991). Complementary roles for the amygdala and hippocampus in aversive conditioning to explicit and contextual cues. Neuroscience, 42, 335-350.
33. Swanson, L. W. (1992). Brain maps: Structure of the rat brain. Amsterdam: Elsevier.
34. Threshold Activity (Version 1.06) [Computer software]. (1996). Burlington, VT: MED Associates.
35. Westbrook, R. F., Good, A. J., & Kieman, M. J. (1997). Microinjection of morphine into the nucleus accumbens impairs contextual learning in rats. Behavioral Neuroscience, 111, 996-1013.