Changes in cytokine levels during admission and mortality in acute alcoholic hepatitis

Alcohol

Volumn 46, Issue 5, 2012, Pages 433-440

  Gonzalez Reimers E ^a   Sanchez Perez M J ^a   Santolaria Fernandez F ^a   Abreu Gonzalez P ^b   De la Vega Prieto, M J ^a   Vina Rodriguez J ^a   Aleman Valls M R ^a   Rodriguez Gaspar M ^a  

^a HOSPITAL UNIVERSITARIO DE CANARIAS   (Spain)

^b UNIVERSIDAD DE LA LAGUNA   (Spain)

Author keywords

Acute phase reaction; Alcoholic hepatitis; Cytokine sequential; Cytokines; Lipid peroxidation; Short term survival

Indexed keywords

BENZODIAZEPINE; C REACTIVE PROTEIN; CEPHALOSPORIN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; LEVOFLOXACIN; MALONALDEHYDE; PREDNISONE; THIAMINE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ALCOHOL LIVER DISEASE; ALCOHOL WITHDRAWAL; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DEATH; FEMALE; FLUID THERAPY; HOSPITAL ADMISSION; HUMAN; INFECTION; LONG TERM SURVIVAL; MAJOR CLINICAL STUDY; MALE; MORTALITY; STATISTICAL ANALYSIS; STEROID THERAPY;

ADULT; C-REACTIVE PROTEIN; CYTOKINES; FEMALE; HEPATITIS, ALCOHOLIC; HOSPITAL MORTALITY; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-4; INTERLEUKIN-6; INTERLEUKIN-8; MALE; MALONDIALDEHYDE; MIDDLE AGED; PATIENT ADMISSION; SURVIVAL ANALYSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84863101965     PISSN: 07418329     EISSN: 18736823     Source Type: Journal    
DOI: 10.1016/j.alcohol.2011.10.001     Document Type: Article

References (33)

1. Bansal S., Liu C.P., Sepuri N.B., Anandatheerthavarada H.K., Selvaraj V., Hoek J., et al. Mitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress. Journal of Biological Chemistry 2010, 285:24609-24619.
2. Bird G. Interleukin-8 in chronic alcoholic liver disease. Acta Gastroenterologica Belgica 1994, 57:255-259.
3. Bird G.L., Sheron N., Goka A.K., Alexander G.J., Williams R.S. Increased plasma tumor necrosis factor in severe alcoholic hepatitis. Annals of Internal Medicine 1990, 112:917-920.
4. Crews F.T., Bechara R., Brown L.A., Guidot D.M., Mandrecker P., Oak S., et al. Cytokines and alcohol. Alcoholism: Clinical & Experimental Research 2006, 30:720-730.
5. Drucker C., Gewiese J., Malchow S., Scheller J., Rose-John S. Impact of interleukin-6 classic and trans-signaling on liver damage and regeneration. Journal of Autoimmunity 2010, 34:29-37.
6. Eggers V., Pascher A., Althoff H., Thiele S., Mütze J., Selignow J., et al. Immune reactivity is more suppressed in patients with alcoholic liver disease than in patients with virus-induced cirrhosis after CRH stimulation. Alcoholism: Clinical & Experimental Research 2006, 30:140-149.
7. El-Assal O., Hong F., Kim W.H., Radaeva S., Gao B. IL-6 deficient mice are susceptible to ethanol-induced hepatic steatosis: IL-6 protects against ethanol-induced oxidative stress and mitochondrial permeability transition in the liver. Cellular and Molecular Immunology 2004, 1:205-211.
8. Frank J., Witte K., Schrödl W., Schütt C. Chronic alcoholism causes deleterious conditioning of innate immunity. Alcohol and Alcoholism 2004, 39:386-392.
9. Fujimoto M., Uemura M., Nakatani Y., Tsujita S., Hoppo K., Tamagawa T., et al. Plasma endotoxin and serum cytokine levels in patients with alcoholic hepatitis: relation to severity of liver disturbance. Alcoholism: Clinical & Experimental Research 2000, 24:48S-54S.
10. Fukui H. Relation of endotoxin, endotoxin binding proteins and macrophages to severe alcoholic liver injury and multiple organ failure. Alcoholism: Clinical & Experimental Research 2005, 29(11 Suppl.):172S-179S.
11. González-Quintela A., Domínguez-Santalla M.J., Pérez L.F., Vidal C., Lojo S., Barrio E. Influence of acute alcohol intake and alcohol withdrawal on circulating levels of IL-6, IL-8, IL-10 and IL-12. Cytokine 2000, 12:1437-1440.
12. González-Reimers E., García-Valdecasas E., Santolaria-Fernández F., de la Vega-Prieto M.J., Ros-Vilamajó R., Martínez-Riera A., et al. Proinflammatory cytokines in stable chronic alcoholics: relationships with lean and fat mass. Food & Chemical Toxicology 2007, 45:904-909.
13. Hernández-Plasencia D., Santolaria-Fernández F., Hernández-García M.T., González-Reimers E., Batista-López N., Jorge-Hernández J.A., et al. Subjective nutritional assessment and short term prognosis. Journal of Nutritional and Environmental Medicine 1991, 2:151-162.
14. Hill D.B., Marsano L.S., Cohen D., Allen J., Shedlofsky S., McClain C.J. Increased plasma interleukin-6 concentrations in alcoholic hepatitis. Journal of Laboratory and Clinical Medicine 1992, 119:547-552.
15. Hill D.B., Marsano L.S., McClain C.J. Increased plasma interleukin-8 concentrations in alcoholic hepatitis. Hepatology 1993, 18:576-580.
16. Huang Y.S., Chan C.Y., Wu J.C., Pai C.H., Chao Y., Lee S.D. Serum levels of interleukin-8 in alcoholic liver disease: relationship with disease stage, biochemical parameters and survival. Journal of Hepatology 1996, 24:377-384.
17. Jayatilleke A., Shaw S. Stimulation of monocyte interleukin-8 by lipid peroxidation products: a mechanism for alcohol-induced liver injury. Alcohol 1998, 16:119-123.
18. Jeong W.I., Park O., Gao B. Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis. Gastroenterology 2008, 134:248-258.
19. Khoruts A., Stahnke L., McClain C.J., Logan G., Allen J.I. Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients. Hepatology 1991, 13:267-276.
20. Kikugawa K., Kojima T., Yamaki S., Kosugi H. Interpretation of the thiobarbituric acid reactivity of rat liver and brain homogenates in the presence of ferric ion and ethylediaminotetraacetic acid. Analytical Biochemistry 1992, 202:249-255.
21. Kono H., Rusyn I., Yin M., Gäbele E., Yamashina S., Dikalova A., et al. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. Journal of Clinical Investigation 2000, 106:867-872.
22. Loguercio C., Federico A. Oxidative stress in viral and alcoholic hepatitis. Free Radical Biology and Medicine 2003, 34:1-10.
23. Louis H., Van Laethem J.L., Wu W., Quertinmont E., Degraef C., Van den Bergh K., et al. Interleukin 10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice. Hepatology 1998, 28:1607-1615.
24. Maddrey W.C., Boitnott J.K., Bedine M.S., Weber F.L., Mezey E., White R.I. Corticosteroid therapy of alcoholic hepatitis. Gastroenterology 1978, 75:193-199.
25. Naveau S., Balian A., Capron F., Raynard B., Fallik D., Agostini H., et al. Balance between pro and anti-inflammatory cytokines in patients with acute alcoholic hepatitis. Gastroenterologie clinique et biologique 2005, 29:269-274.
26. Poli G. Pathogenesis of liver fibrosis: role of oxidative stress. Molecular Aspects of Medicine 2000, 21:49-98.
27. Qin L., He J., Hanes R.N., Pluzarev O., Hong J.S., Crews F.T. Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment. Journal of Neuroinflammation 2008, 10.1186/1742-2094-5-10.
28. Rao R.K., Seth A., Sheth P. Recent advances in alcoholic liver disease I. Role of intestinal permeability and endotoxemia in alcoholic liver disease. American Journal of Physiology - Gastrointestinal and Liver Physiology 2004, 286:G881-G884.
29. Sheron N., Bird G., Koskinas J., Portmann B., Ceska M., Lindley I., et al. Circulating and tissue levels of the neutrophil chemotaxin interleukin-8 are elevated in severe acute alcoholic hepatitis, and tissue levels correlate with neutrophil infiltration. Hepatology 1993, 18:41-46.
30. Steinbrenner H., Sies H. Protection against reactive oxygen species by selenoproteins. Biochimica et Biophysica Acta 2009, 1790:1478-1485.
31. Stewart S.F., Vidali M., Day C.P., Albano E., Jones D.E. Oxidative stress as a trigger for cellular immune responses in patients with alcoholic liver disease. Hepatology 2004, 39:197-203.
32. Tuma D.J. Role of malondialdehyde-acetaldehyde adducts in liver injury. Free Radical Biology and Medicine 2002, 32:303-308.
33. Zhang X., Tachibana S., Wang H., Hisada M., Williams G.M., Gao B., et al. Interleukin-6 is an important mediator for mitochondrial DNA repair after alcoholic liver injury in mice. Hepatology 2010, 52:2137-2147.