Immune reactivity is more suppressed in patients with alcoholic liver disease than in patients with virus-induced cirrhosis after CRH stimulation

Alcoholism: Clinical and Experimental Research

Volumn 30, Issue 1, 2006, Pages 140-149

  Eggers, Verena ^a   Pascher, Andreas ^a   Althoff, Hilke ^a   Thiele, Stefanie ^a   Mütze, Juliane ^a   Selignow, Julia ^a   Neuhaus, Peter ^a   Spies, Claudia D ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Alcoholic Liver Cirrhosis (ALD); Immunosuppression; Liver Transplantation; Virus Induced Cirrhosis (VIC)

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; INTERLEUKIN 10; INTERLEUKIN 6; LIPOPOLYSACCHARIDE;

ABSTINENCE; ADULT; ALCOHOL LIVER DISEASE; ARTICLE; BLOOD; BLOOD SAMPLING; CLINICAL ARTICLE; CYTOTOXIC T LYMPHOCYTE; EXERCISE TEST; FEMALE; HORMONE ACTION; HUMAN; IMMUNOREACTIVITY; IMMUNOSUPPRESSIVE TREATMENT; INFECTION; INFECTION RATE; LIVER CIRRHOSIS; LIVER TRANSPLANTATION; MALE; PATIENT; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; STRESS; VIRUS INDUCTION;

ADRENOCORTICOTROPIC HORMONE; ADULT; BETA-ENDORPHIN; CD4-CD8 RATIO; CORTICOTROPIN-RELEASING HORMONE; CYTOKINES; EXERCISE TEST; FEMALE; FLOW CYTOMETRY; HEPATITIS B, CHRONIC; HEPATITIS C, CHRONIC; HUMANS; HYDROCORTISONE; IMMUNE TOLERANCE; INFLAMMATION MEDIATORS; INJECTIONS, INTRAVENOUS; LIVER CIRRHOSIS; LIVER CIRRHOSIS, ALCOHOLIC; LIVER TRANSPLANTATION; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; PITUITARY-ADRENAL SYSTEM; REFERENCE VALUES; T-LYMPHOCYTES, CYTOTOXIC;

EID: 33644756653     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2006.00014.x     Document Type: Article

References (36)

1. American Psychiatric Association 1991 Grant, 1992.
2. Brune IB Wilke W Hensler T Holzmann B Siewert JR 1999 Downregulation of T helper type 1 immune response and altered pro-inflammatory and anti-inflammatory T cell cytokine balance following conventional but not laparoscopic surgery Am J Surg 177 55 60
3. Brunner E Domhof S Langer F 2002 Non-Parametric Analysis of Longitudinal Data in Factorial Experiments John Wiley & Sons, Wiley-Interscience New York
4. Chedid A Mendenhall CL Moritz TE French SW Chen TS Morgan TR Roselle GA Nemchausky BA Tamburro CH Schiff ER et al. 1993 Cell-mediated hepatic injury in alcoholic liver disease. Veterans Affairs Cooperative Study Group 275 Gastroenterology 105 254 266
5. Daniluk J Szuster-Ciesielska A Drabko J Kandefer-Szerszen M 2001 Serum cytokine levels in alcohol-related liver cirrhosis Alcohol 23 29 34
6. del Arbol JL Aguirre JC Raya J Rico J Ruiz-Requena ME Miranda MT 1995 Plasma concentrations of beta-endorphin, adrenocorticotropic hormone, and cortisol in drinking and abstinent chronic alcoholics Alcohol 12 525 529
7. Demetris A Adams D Bellamy C Blakolmer K Clouston A Dhillon AP Fung J Gouw A Gustafsson B Haga H Harrison D Hart J Hubscher S Jaffe R Khettry U Lassman C Lewin K Martinez O Nakazawa Y Neil D Pappo O Parizhskaya M Randhawa P Rasoul-Rockenschaub S Reinholt F Reynes M Robert M Tsamandas A Wanless I Wiesner R Wernerson A Wrba F Wyatt J Yamabe H 2000 Update of the International Banff Schema for Liver Allograft Rejection working recommendations for the histopathologic staging and reporting of chronic rejection. An International Panel Hepatology 31 792 799
8. Dhabhar FS Miller AH McEwen BS Spencer RL 1995 Effects of stress on immune cell distribution. Dynamics and hormonal mechanisms J Immunol 154 5511 5527
9. Diez Ruiz A Santos Perez JL Lopez Martinez G Gonzalez Calvin J Gil Extremera B Gutierrez Gea F 1993 Tumour necrosis factor, interleukin-1 and interleukin-6 in alcoholic cirrhosis Alcohol Alcoholism 28 319 323
10. Ehrenreich H Schuck J Stender N Pilz J Gefeller O Schilling L Poser W Kaw S 1997 Endocrine and hemodynamic effects of stress versus systemic CRF in alcoholics during early and medium term abstinence Alcohol Clin Exp Res 21 1285 1293
11. Ewing JA 1984 Detecting alcoholism. The CAGE questionnaire JAMA 252 1905 1907
12. Farges O Saliba F Farhamant H Samuel D Bismuth A Reynes M Bismuth H 1996 Incidence of rejection and infection after liver transplantation as a function of the primary disease possible influence of alcohol and polyclonal immunoglobulins Hepatology 23 240 248
13. Garner JS Jarvis WR Emori TG Horan TC Hughes JM 1988 CDC definitions for nosocomial infections, 1988 Am J Infect Control 16 128 140
14. Hayashi M Keeffe EB Krams SM Martinez OM Ojogho ON So SK Garcia G Imperial JC Esquivel CO 1998 Allograft rejection after liver transplantation for autoimmune liver diseases Liver Transpl Surg 4 208 214
15. Imrich R Tibenska E Koska J Ksinantova L Kvetnansky R Bergendiova-Sedlackova K Blazicek P Vigas M 2004 Repeated stress-induced stimulation of catecholamine response is not followed by altered immune cell redistribution Ann N Y Acad Sci 1018 266 272
16. Kakumu S Okumura A Ishikawa T Iwata K Yano M Yoshioka K 1997 Production of interleukins 10 and 12 by peripheral blood mononuclear cells (PBMC) in chronic hepatitis C virus (HCV) infection Clin Exp Immunol 108 138 143
17. Khoruts A Stahnke L McClain CJ Logan G Allen JI 1991 Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients Hepatology 13 267 276
18. Kirmaz C Terzioglu E Topalak O Bayrak P Yilmaz O Ersoz G Sebik F 2004 Serum tumor growth factor-beta1 levels in patients with cirrhosis, chronic hepatitis B and chronic hepatitis C Eur Cytokine Netw 15 112 116
19. Laso FJ Iglesias-Osma C Ciudad J Lopez A Pastor I Orfao A 1999 Chronic alcoholism is associated with an imbalanced production of Th-1/Th-2 cytokines by peripheral blood T cells Alcohol Clin Exp Res 23 1306 1311
20. McMichael AJ Rowland-Jones SL 2001 Cellular immune responses to HIV Nature 19 980 987
21. Mosmann TR Sad S 1996 The expanding universe of T-cell subsets Th1, Th2 and more Rev Immunol Today 17 138 146
22. Napoli J Bishop GA McGuinness PH Painter DM McCaughan GW 1996 Progressive liver injury in chronic hepatitis C infection correlates with increased intrahepatic expression of Th1-associated cytokines Hepatology 24 759 765
23. Neuberger J 1999 Incidence, timing, and risk factors for acute and chronic rejection Liver Transpl Surg 5 S30 S36
24. Neumann T Müller C Rommelspacher H Spies C 1998 Chronic alcoholics at risk in the postoperative intensive care unit stay Alcohol Clin Exp Res 22 5
25. Pageaux GP Michel J Coste V Perney P Possoz P Perrigault PF Navarro F Fabre JM Domergue J Blanc P Larrey D 1999 Alcoholic cirrhosis is a good indication for liver transplantation even for cases of recidivism Gut 45 421 426
26. Platz KP Mueller AR Spree E Schumacher G Nussler NC Rayes N Glanemann M Bechstein WO Neuhaus P 2000 Liver transplantation for alcoholic cirrhosis Transpl Int 13 S127 S130
27. Sander M Irwin M Sinha P Naumann E Kox WJ Spies CD 2002 Suppression of interleukin-6 to interleukin-10 ratio in chronic alcoholics association with postoperative infections Intensive Care Med 28 285 292
28. Serbina NV Lazarevic V Flynn JL 2001 CD4(+) T cells are required for the development of cytotoxic CD8(+) T cells during Mycobacterium tuberculosis infection J Immunol 167 6991 7000
29. Spies CD von Dossow V Eggers V Jetschmann G El-Hilali R Egert J Fischer M Schroder T Hoflich C Sinha P Paschen C Mirsalim P Brunsch R Hopf J Marks C Wernecke KD Pragst F Ehrenreich H Muller C Tonnesen H Oelkers W Rohde W Stein C Kox WJ 2004 Altered cell-mediated immunity and increased postoperative infection rate in long-term alcoholic patients Anesthesiology 100 1088 1100
30. Szabo G Mandrekar P Dolganiuc A 2001 Reduced alloreactive T cell activation after alcohol intake is due to impaired monocyte accessory cell function and correlates with elevated IL-10, IL-13 and decreased IFN gamma levels Alcohol Clin Exp Res 25 1766 1772
31. Tønnesen H Kaiser AH Nielsen Pedersen AE 1992a Reversibility of alcohol-induced immune depression Br J Addict 87 1025 1028
32. Tønnesen H Petersen KR Hojgaard L Stokholm KH Nielsen HJ Knigge U Kehlet H 1992b Postoperative morbidity among symptom-free alcohol misusers Lancet 340 334 337
33. Udelsman R Holbrook NJ 1994 Endocrine and molecular responses to surgical stress Curr Probl Surg 31 653 720
34. von Heymann C Langenkamp J Dubisz N von Dossow V Schaffartzik W Kern H Kox WJ Spies C 2002 Posttraumatic immune modulation in chronic alcoholics is associated with multiple organ dysfunction syndrome J Trauma 52 95 103
35. Yoshioka K Kakumu S Arao M Tsutsumi Y Inoue M 1989 Tumor necrosis factor alpha production by peripheral blood mononuclear cells of patients with chronic liver disease Hepatology 10 769 773
36. Zedler S Faist E Ostermeier B von Donnersmarck GH Schildberg FW 1997 Postburn constitutional changes in T-cell reactivity occur in CD8+ rather than in CD4+ cells J Trauma 42 872 880