메뉴 건너뛰기




Volumn 125, Issue 7, 2012, Pages 1657-1665

TOR signaling regulates planarian stem cells and controls localized and organismal growth

Author keywords

Planarian; Regeneration; Stem cells; TOR

Indexed keywords

DNA; TARGET OF RAPAMYCIN KINASE;

EID: 84863089665     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.104711     Document Type: Article
Times cited : (43)

References (42)
  • 1
    • 0002170118 scopus 로고
    • Mitosis in the intact and regenerating planarian Dugesia mediterranea n.sp. I. Mitotic studies during growth, feeding and starvation
    • Baguñà, J. (1976). Mitosis in the intact and regenerating planarian Dugesia mediterranea n.sp. I. Mitotic studies during growth, feeding and starvation. J. Exp. Zool. 195, 53-64.
    • (1976) J. Exp. Zool. , vol.195 , pp. 53-64
    • Baguñà, J.1
  • 2
    • 9644306768 scopus 로고
    • The function of the brain in Planaria maculata
    • Bardeen, C. R. (1901). The function of the brain in Planaria maculata. Am. J. Physiol. 5, 175-179.
    • (1901) Am. J. Physiol. , vol.5 , pp. 175-179
    • Bardeen, C.R.1
  • 3
    • 54949153140 scopus 로고    scopus 로고
    • Comparative aspects of animal regeneration
    • Brockes, J. P. and Kumar, A. (2008). Comparative aspects of animal regeneration. Annu. Rev. Cell Dev. Biol. 24, 525-549.
    • (2008) Annu. Rev. Cell Dev. Biol. , vol.24 , pp. 525-549
    • Brockes, J.P.1    Kumar, A.2
  • 5
    • 68349122622 scopus 로고    scopus 로고
    • Apoptotic cells provide an unexpected source of Wnt3 signaling to drive hydra head regeneration
    • Chera, S., Ghila, L., Dobretz, K., Wenger, Y., Bauer, C., Buzgariu, W., Martinou, J. C. and Galliot, B. (2009). Apoptotic cells provide an unexpected source of Wnt3 signaling to drive hydra head regeneration. Dev. Cell 17, 279-289.
    • (2009) Dev. Cell , vol.17 , pp. 279-289
    • Chera, S.1    Ghila, L.2    Dobretz, K.3    Wenger, Y.4    Bauer, C.5    Buzgariu, W.6    Martinou, J.C.7    Galliot, B.8
  • 6
    • 51049089115 scopus 로고    scopus 로고
    • Molecular analysis of stem cells and their descendants during cell turnover and regeneration in the planarian Schmidtea mediterranea
    • Eisenhoffer, G. T., Kang, H. and Sánchez Alvarado, A. (2008). Molecular analysis of stem cells and their descendants during cell turnover and regeneration in the planarian Schmidtea mediterranea. Cell Stem Cell 3, 327-339.
    • (2008) Cell Stem Cell , vol.3 , pp. 327-339
    • Eisenhoffer, G.T.1    Kang, H.2    Sánchez Alvarado, A.3
  • 8
    • 0037097863 scopus 로고    scopus 로고
    • Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
    • Fingar, D. C., Salama, S., Tsou, C., Harlow, E. and Blenis, J. (2002). Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev. 16, 1472-1487.
    • (2002) Genes Dev , vol.16 , pp. 1472-1487
    • Fingar, D.C.1    Salama, S.2    Tsou, C.3    Harlow, E.4    Blenis, J.5
  • 9
    • 27144556646 scopus 로고    scopus 로고
    • Cell size reduction induced by inhibition of the mTOR/S6K-signaling pathway protects Jurkat cells from apoptosis
    • Fumarola, C., La Monica, S., Alfieri, R. R., Borra, E. and Guidotti, G. G. (2005). Cell size reduction induced by inhibition of the mTOR/S6K-signaling pathway protects Jurkat cells from apoptosis. Cell Death Differ. 12, 1344-1357.
    • (2005) Cell Death Differ , vol.12 , pp. 1344-1357
    • Fumarola, C.1    La Monica, S.2    Alfieri, R.R.3    Borra, E.4    Guidotti, G.G.5
  • 11
    • 78650873849 scopus 로고    scopus 로고
    • The planarian flatworm: an in vivo model for stem cell biology and nervous system regeneration
    • Gentile, L., Cebrià, F. and Bartscherer, K. (2011). The planarian flatworm: an in vivo model for stem cell biology and nervous system regeneration. Dis. Model. Mech. 4, 12-19.
    • (2011) Dis. Model. Mech. , vol.4 , pp. 12-19
    • Gentile, L.1    Cebrià, F.2    Bartscherer, K.3
  • 12
    • 33746518104 scopus 로고    scopus 로고
    • A Bruno-like gene is required for stem cell maintenance in planarians
    • Guo, T., Peters, A. H. and Newmark, P. A. (2006). A Bruno-like gene is required for stem cell maintenance in planarians. Dev. Cell 11, 159-169.
    • (2006) Dev. Cell , vol.11 , pp. 159-169
    • Guo, T.1    Peters, A.H.2    Newmark, P.A.3
  • 13
    • 77957316159 scopus 로고    scopus 로고
    • Expression of secreted Wnt pathway components reveals unexpected complexity of the planarian amputation response
    • Gurley, K. A., Elliott, S. A., Simakov, O., Schmidt, H. A., Holstein, T. W. and Sánchez Alvarado, A. (2010). Expression of secreted Wnt pathway components reveals unexpected complexity of the planarian amputation response. Dev. Biol. 347, 24-39.
    • (2010) Dev. Biol. , vol.347 , pp. 24-39
    • Gurley, K.A.1    Elliott, S.A.2    Simakov, O.3    Schmidt, H.A.4    Holstein, T.W.5    Sánchez Alvarado, A.6
  • 14
    • 2942557111 scopus 로고    scopus 로고
    • Detection of apoptosis during planarian regeneration by the expression of apoptosis-related genes and TUNEL assay
    • Hwang, J. S., Kobayashi, C., Agata, K., Ikeo, K. and Gojobori, T. (2004). Detection of apoptosis during planarian regeneration by the expression of apoptosis-related genes and TUNEL assay. Gene 333, 15-25.
    • (2004) Gene , vol.333 , pp. 15-25
    • Hwang, J.S.1    Kobayashi, C.2    Agata, K.3    Ikeo, K.4    Gojobori, T.5
  • 15
    • 77953299671 scopus 로고    scopus 로고
    • Specific roles of Target of rapamycin in the control of stem cells and their progeny in the Drosophila ovary
    • LaFever, L., Feoktistov, A., Hsu, H. J. and Drummond-Barbosa, D. (2010). Specific roles of Target of rapamycin in the control of stem cells and their progeny in the Drosophila ovary. Development 137, 2117-2126.
    • (2010) Development , vol.137 , pp. 2117-2126
    • LaFever, L.1    Feoktistov, A.2    Hsu, H.J.3    Drummond-Barbosa, D.4
  • 16
    • 33847386180 scopus 로고    scopus 로고
    • Target of rapamycin (TOR) signaling controls epithelial morphogenesis in the vertebrate intestine
    • Makky, K., Tekiela, J. and Mayer, A. N. (2007). Target of rapamycin (TOR) signaling controls epithelial morphogenesis in the vertebrate intestine. Dev. Biol. 303, 501-513.
    • (2007) Dev. Biol. , vol.303 , pp. 501-513
    • Makky, K.1    Tekiela, J.2    Mayer, A.N.3
  • 17
    • 0004285336 scopus 로고
    • New York: The Macmillan Company
    • Morgan, T. H. (1901). Regeneration. New York: The Macmillan Company
    • (1901) Regeneration
    • Morgan, T.H.1
  • 19
    • 0342369613 scopus 로고    scopus 로고
    • Bromodeoxyuridine specifically labels the regenerative stem cells of planarians
    • Newmark, P. A. and Sánchez Alvarado, A. (2000). Bromodeoxyuridine specifically labels the regenerative stem cells of planarians. Dev. Biol. 220, 142-153.
    • (2000) Dev. Biol. , vol.220 , pp. 142-153
    • Newmark, P.A.1    Sánchez Alvarado, A.2
  • 20
    • 0034312279 scopus 로고    scopus 로고
    • Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
    • Oldham, S., Montagne, J., Radimerski, T., Thomas, G. and Hafen, E. (2000). Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev. 14, 2689-2694.
    • (2000) Genes Dev , vol.14 , pp. 2689-2694
    • Oldham, S.1    Montagne, J.2    Radimerski, T.3    Thomas, G.4    Hafen, E.5
  • 21
    • 0037310238 scopus 로고    scopus 로고
    • Allometric scaling and proportion regulation in the freshwater planarian Schmidtea mediterranea
    • Oviedo, N. J., Newmark, P. A. and Sánchez Alvarado, A. (2003). Allometric scaling and proportion regulation in the freshwater planarian Schmidtea mediterranea. Dev. Dyn. 226, 326-333.
    • (2003) Dev. Dyn. , vol.226 , pp. 326-333
    • Oviedo, N.J.1    Newmark, P.A.2    Sánchez Alvarado, A.3
  • 22
    • 64249153813 scopus 로고    scopus 로고
    • Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling
    • discussion 141
    • Oviedo, N. J., Pearson, B. J., Levin, M. and Sánchez Alvarado, A. (2008). Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling. Dis. Model. Mech. 1, 131-143, discussion 141.
    • (2008) Dis. Model. Mech , vol.1 , pp. 131-143
    • Oviedo, N.J.1    Pearson, B.J.2    Levin, M.3    Sánchez Alvarado, A.4
  • 27
    • 77956873456 scopus 로고    scopus 로고
    • Advances in understanding tissue regenerative capacity and mechanisms in animals
    • Poss, K. D. (2010). Advances in understanding tissue regenerative capacity and mechanisms in animals. Nat. Rev. Genet. 11, 710-722.
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 710-722
    • Poss, K.D.1
  • 31
    • 79960761944 scopus 로고    scopus 로고
    • An emerging role for TOR signaling in mammalian tissue and stem cell physiology
    • Russell, R. C., Fang, C. and Guan, K. L. (2011). An emerging role for TOR signaling in mammalian tissue and stem cell physiology. Development 138, 3343-3356.
    • (2011) Development , vol.138 , pp. 3343-3356
    • Russell, R.C.1    Fang, C.2    Guan, K.L.3
  • 32
    • 0021646660 scopus 로고
    • Regeneration and pattern formation in planarians. I. The pattern of mitosis in anterior and posterior regeneration in Dugesia (G) tigrina, and a new proposal for blastema formation
    • Saló, E. and Baguñà, J. (1984). Regeneration and pattern formation in planarians. I. The pattern of mitosis in anterior and posterior regeneration in Dugesia (G) tigrina, and a new proposal for blastema formation. J. Embryol. Exp. Morphol. 83, 63-80.
    • (1984) J. Embryol. Exp. Morphol. , vol.83 , pp. 63-80
    • Saló, E.1    Baguñà, J.2
  • 33
    • 0141671441 scopus 로고    scopus 로고
    • Regeneration in the metazoans: why does it happen
    • Sánchez Alvarado, A. (2000). Regeneration in the metazoans: why does it happen? Bioessays 22, 578-590.
    • (2000) Bioessays , vol.22 , pp. 578-590
    • Sánchez Alvarado, A.1
  • 34
    • 0036923338 scopus 로고    scopus 로고
    • The Schmidtea mediterranea database as a molecular resource for studying platyhelminthes, stem cells and regeneration
    • Sánchez Alvarado, A., Newmark, P. A., Robb, S. M. and Juste, R. (2002). The Schmidtea mediterranea database as a molecular resource for studying platyhelminthes, stem cells and regeneration. Development 129, 5659-5665.
    • (2002) Development , vol.129 , pp. 5659-5665
    • Sánchez Alvarado, A.1    Newmark, P.A.2    Robb, S.M.3    Juste, R.4
  • 35
    • 74849131091 scopus 로고    scopus 로고
    • Targeting mTOR globally in cancer: thinking beyond rapamycin
    • Shor, B., Gibbons, J. J., Abraham, R. T. and Yu, K. (2009). Targeting mTOR globally in cancer: thinking beyond rapamycin. Cell Cycle 8, 3831-3837.
    • (2009) Cell Cycle , vol.8 , pp. 3831-3837
    • Shor, B.1    Gibbons, J.J.2    Abraham, R.T.3    Yu, K.4
  • 37
    • 33845602214 scopus 로고    scopus 로고
    • Apoptosis is required during early stages of tail regeneration in Xenopus laevis
    • Tseng, A. S., Adams, D. S., Qiu, D., Koustubhan, P. and Levin, M. (2007). Apoptosis is required during early stages of tail regeneration in Xenopus laevis. Dev. Biol. 301, 62-69.
    • (2007) Dev. Biol. , vol.301 , pp. 62-69
    • Tseng, A.S.1    Adams, D.S.2    Qiu, D.3    Koustubhan, P.4    Levin, M.5
  • 38
    • 79955985703 scopus 로고    scopus 로고
    • Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration
    • Wagner, D. E., Wang, I. E. and Reddien, P. W. (2011). Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration. Science 332, 811-816.
    • (2011) Science , vol.332 , pp. 811-816
    • Wagner, D.E.1    Wang, I.E.2    Reddien, P.W.3
  • 39
    • 77955274843 scopus 로고    scopus 로고
    • Planarian regeneration involves distinct stem cell responses to wounds and tissue absence
    • Wenemoser, D. and Reddien, P. W. (2010). Planarian regeneration involves distinct stem cell responses to wounds and tissue absence. Dev. Biol. 344, 979-991.
    • (2010) Dev. Biol. , vol.344 , pp. 979-991
    • Wenemoser, D.1    Reddien, P.W.2
  • 40
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger, S., Loewith, R. and Hall, M. N. (2006). TOR signaling in growth and metabolism. Cell 124, 471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 42
    • 78650510609 scopus 로고    scopus 로고
    • mTOR: from growth signal integration to cancer, diabetes and ageing
    • Zoncu, R., Efeyan, A. and Sabatini, D. M. (2011). mTOR: from growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 12, 21-35.
    • (2011) Nat. Rev. Mol. Cell Biol. , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.