O-GlcNAc modification of the anti-malarial vaccine candidate PfAMA1: in silico-defined structural changes and potential to generate a better vaccine

Molecular Biology Reports

Volumn 39, Issue 4, 2012, Pages 4663-4672

  Uddin, Nasir ^a   Hoessli, Daniel C ^a,b   Butt, Asma ^a   Kaleem, Afshan ^a,c   Iqbal, Zeeshan ^a   Afzal, Imran ^a   Hammad, Muhammad ^a   Zamani, Zahra ^d   Shakoori, Abdul Rauf ^e  

^a Institute of Molecular Sciences and Bioinformatics Lahore   (Pakistan)

^b UNIVERSITY OF KARACHI   (Pakistan)

^c Women University   (Pakistan)

^d PASTEUR INSTITUTE OF IRAN   (Iran)

^e UNIVERSITY OF THE PUNJAB   (Pakistan)

Author keywords

Anti malarial vaccine; Apical membrane antigen 1(AMA1); O GlcNAc; Plasmodium falciparum; Post translational modifications (PTMs) O linked N acetylglucosamine (OGT); TPR

Indexed keywords

APICAL MEMBRANE ANTIGEN 1; MALARIA VACCINE; N ACETYLGLUCOSAMINE; O LINKED N ACETYLGLUCOSAMINE; UNCLASSIFIED DRUG; AMINO ACID; N ACETYLGLUCOSAMINYLTRANSFERASE; PROTOZOAL PROTEIN; UDP N ACETYLGLUCOSAMINE PEPTIDE BETA N ACETYLGLUCOSAMINYLTRANSFERASE; UDP-N-ACETYLGLUCOSAMINE-PEPTIDE BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPUTER MODEL; CRYSTAL STRUCTURE; GLYCOSYLATION; HUMAN; HYDROGEN BOND; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOMODULATION; MEROZOITE; MOLECULAR DOCKING; NUCLEAR LOCALIZATION SIGNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN GLYCOSYLATION; PROTEIN PROTEIN INTERACTION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SPOROZOITE; TETRATRICOPEPTIDE REPEAT; VACCINE PRODUCTION; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; PLASMODIUM FALCIPARUM; PROTEIN PROCESSING; PROTEIN SECONDARY STRUCTURE;

PLASMODIUM FALCIPARUM;

ACETYLGLUCOSAMINE; AMINO ACID SEQUENCE; AMINO ACIDS; COMPUTATIONAL BIOLOGY; GLYCOSYLATION; HUMANS; HYDROGEN BONDING; MALARIA VACCINES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; N-ACETYLGLUCOSAMINYLTRANSFERASES; PLASMODIUM FALCIPARUM; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, SECONDARY; PROTOZOAN PROTEINS; SEQUENCE ALIGNMENT;

EID: 84863083551     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-011-1258-4     Document Type: Article

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