Mutations in isocitrate dehydrogenase 2 accelerate glioma cell migration via matrix metalloproteinase-2 and 9

Biotechnology Letters

Volumn 34, Issue 3, 2012, Pages 441-446

  Fu, Yuejun ^a   Zheng, Yali ^a   Li, Ke ^b   Huang, Rui ^a   Zheng, Shuhua ^a   An, Na ^a   Liang, Aihua ^a  

^a SHANXI UNIVERSITY   (China)

^b Zhejiang Entry Exit Inspection and Quarantine Bureau   (China)

Author keywords

Glioma cancer; Isocitrate dehydrogenase 2 (IDH2); Matrix metalloproteinase 2, 9; Migration

Indexed keywords

AMINO ACID SUBSTITUTION; CELL MIGRATION; EXTRACELLULAR MATRICES; GLIOBLASTOMA MULTIFORME; GLIOMA CANCER; GLIOMA CELLS; ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE-2 (IDH2); KETOGLUTARATE; LOW LEVEL; MATRIX METALLOPROTEINASE-2; MATRIX METALLOPROTEINASES; MIGRATION; TUMOR GROWTH;

AMINO ACIDS; BLOOD VESSELS; CELLS; CYTOLOGY; DISEASES; ENZYME ACTIVITY; ENZYME INHIBITION; GENE ENCODING;

TUMORS;

2 OXOGLUTARIC ACID; ALPHA-KETOGLUTARIC ACID; GELATINASE A; GELATINASE B; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; ISOCITRATE DEHYDROGENASE; MUTANT PROTEIN;

ANIMAL; ARTICLE; CELL MOTION; ENZYMOLOGY; GENETICS; GLIA; METABOLISM; MUTATION; PHYSIOLOGY; RAT; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; ISOCITRATE DEHYDROGENASE; KETOGLUTARIC ACIDS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MUTANT PROTEINS; MUTATION; NEUROGLIA; RATS;

EID: 84863077134     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-011-0800-8     Document Type: Article

References (16)

1. Badiga AV, Chetty C, Kesanakurti D, Are D, Gujrati M, Klopfenstein JD, Dinh DH, Rao JS (2011) MMP-2 siRNA inhibits radiation-enhanced invasiveness in glioma cells. PloS One 6: e20614.
2. Berg G, Miksztowicz V, Schreier L (2011) Metalloproteinases in metabolic syndrome. Clin Chim Acta 412: 1731-1739.
3. Castro MM, Kandasamy AD, Youssef N, Schulz R (2011) Matrix metalloproteinase inhibitor properties of tetracyclines: therapeutic potential in cardiovascular diseases. Pharmacol Res 64(6): 551-560.
4. Chen RX, Cui JF, Xu CD, Xue TC, Guo K, Gao DM, Liu YK, Ye SL, Ren ZG (2011) The significance of MMP-9 over MMP-2 in HCC invasiveness and recurrence of hepatocellular carcinoma after curative resection. Ann Surg Oncol (Online).
5. Deshane J, Garner CC, Sontheimer H (2003) Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2. J Biol Chem 278: 4135-4144.
6. Fu YJ, Huang R, Du J, Yang RJ, An N, Liang AH (2010) Glioma-derived mutations in IDH: from mechanism to potential therapy. Biochem Biophys Res Commun 397: 127-130.
7. Fu YJ, An N, Chan KG, Wu YB, Zheng SH, Liang AH (2011a) A model of BmK CT in inhibiting glioma cell migration via matrix metalloproteinase-2 from experimental and molecular dynamics simulation study. Biotechnol Lett 33: 1309-1317.
8. Fu YJ, Huang R, Zheng YL, Zhang ZY, Liang AH (2011b) Glioma-derived mutations in isocitrate dehydrogenase 2 beneficial to traditional chemotherapy. Biochem Biophys Res Commun 410: 218-223.
9. Giese A, Westphal M (1996) Glioma invasion in the central nervous system. Neurosurgery 39: 235-250.
10. Gladson CL (1999) The extracelular matrix of gliomas: modulation of cell function. J Neuropathol Exp Neurol 58: 1029-1040.
11. Ji HT, Wang J, Fang B, Fang X, Lu Z (2011) α-Catenin inhibits glioma cell migration, invasion, and proliferation by suppression of β-catenin transactivation. J Neurooncol 103: 445-451.
12. Lee SY, Park SY, Kim SH, Choi EC (2011) Expression of matrix metalloproteiases and their inhibition in squamous cell carcinoma of the tonsil and their clinical significance. Clin Exp Otorhinolaryngol 4: 88-94.
13. Li LW, Chen P, Ling Y, Song XM, Lu ZJ, He QH, Li ZY, Lu N, Guo QL (2011) Inhibitory effects of GL-V9 on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-2/9. Eur J Pharm Sci 43: 393-399.
14. Ranogajec I, Razumovic JJ, Puzovic V, Gabrilovac J (2011) Prognostic value of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and aminopeptidase N/CD13 in breast cancer patients. Med Oncol (Online).
15. Shao WL, Wang W, Xiong XG, Cao C, Yan TD, Chen GQ, Chen HZ, Yin WQ, Liu J, Gu YY, Mo MC, He JX (2011) Prognostic impact of MMP-2 and MMP-9 expression in pathologic stage IA non-small cell lung cancer. J Surg Oncol 104(7): 841-846.
16. Zhao SM, Lin Y, Xu W, Jiang WQ, Zha ZY, Wang P, Yu W, Li ZQ, Gong LL, Peng YJ, Ding JP, Lei QY, Guan KL, Xiong Y (2009) Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α. Science 324: 261-265.