Impaired lysosomal trimming of N-linked oligosaccharides leads to hyperglycosylation of native lysosomal proteins in mice with α-mannosidosis

Molecular and Cellular Biology

Volumn 30, Issue 1, 2010, Pages 273-283

  Damme, Markus ^a   Morelle, Willy ^b   Schmidt, Bernhard ^a   Andersson, Claes ^c   Fogh, Jens ^c   Michalski, Jean Claude ^b   Lübke, Torben ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITÉ DES SCIENCES ET TECHNOLOGIES DE LILLE   (France)

^c Zymenex AS   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA MANNOSIDASE; ASPARAGINE LINKED OLIGOSACCHARIDE; CATHEPSIN B; CATHEPSIN E; GLYCOPROTEIN; LYSOSOME PROTEIN; MAN3GLNAC2 OLIGOSACCHARIDE; NPC2 PROTEIN; OLIGOSACCHARIDE; PROTEIN; RECOMBINANT ENZYME; SCPEP1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; CATABOLISM; CONTROLLED STUDY; DEGLYCOSYLATION; HYPERMANNOSYLATION; IN VITRO STUDY; IN VIVO STUDY; LYSOSOME; MANNOSIDOSIS; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; TWO DIMENSIONAL GEL ELECTROPHORESIS;

ALPHA-MANNOSIDASE; ALPHA-MANNOSIDOSIS; ANIMALS; CATHEPSIN B; ENZYME REPLACEMENT THERAPY; GLYCOSYLATION; HUMANS; LIVER; LYSOSOMES; MICE; MICE, INBRED C57BL; OLIGOSACCHARIDES; PROTEINS; RECOMBINANT PROTEINS;

MUS;

EID: 73549116509     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01143-09     Document Type: Article

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