The carboxy-terminal domain of the XPC protein plays a crucial role in nucleotide excision repair through interactions with transcription factor IIH

DNA Repair

Volumn 1, Issue 6, 2002, Pages 449-461

  Uchida, Akio ^a,b   Sugasawa, Kaoru ^b,d   Masutani, Chikahide ^a,b   Dohmae, Naoshi ^c   Araki, Marito ^a   Yokoi, Masayuki ^a,b   Ohkuma, Yoshiaki ^a,b   Hanaoka, Fumio ^a,b,d  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c R1KEN   (Japan)

^d RIKEN   (Japan)

Author keywords

Nucleotide excision repair; TFIIH; Xeroderma pigmentosum; XPC

Indexed keywords

CHICKEN OVALBUMIN UPSTREAM PROMOTER TRANSCRIPTION FACTOR; CELL EXTRACT; DNA; DNA BINDING PROTEIN; FUNGAL PROTEIN; HISTIDINE; PRIMER DNA; RAD23 PROTEIN, FUNGAL; RECOMBINANT PROTEIN; TRANSCRIPTION FACTOR II; TRANSCRIPTION FACTOR IIH; XPC PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BUDDING; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA BINDING; DNA DAMAGE; EXCISION REPAIR; GENE DELETION; GENE MAPPING; GENE MUTATION; GENOME; HUMAN; HUMAN CELL; MAMMAL; MOLECULAR EVOLUTION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; SEQUENCE HOMOLOGY; XERODERMA PIGMENTOSUM; BACULOVIRUS; CELL CULTURE; CHEMISTRY; DNA REPAIR; GENETICS; ISOLATION AND PURIFICATION; LYMPHOCYTE; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

BACULOVIRIDAE; CELL EXTRACTS; CELLS, CULTURED; DNA; DNA DAMAGE; DNA PRIMERS; DNA REPAIR; DNA-BINDING PROTEINS; FUNGAL PROTEINS; HISTIDINE; HUMAN; LYMPHOCYTES; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE DELETION; SUPPORT, NON-U.S. GOV'T; TRANSCRIPTION FACTORS, TFII; HUMANS; TRANSCRIPTION FACTOR TFIIH;

MAMMALIA; SACCHAROMYCETALES;

EID: 0037150494     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1568-7864(02)00031-9     Document Type: Article

References (49)

1. Nucleotide excision repair and the link with transcription
2. Nucleotide excision repair in mammalian cells
3. The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η
4. HRAD30 mutations in the variant form of xeroderma pigmentosum
5. Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group C
6. Cloning and nucleotide sequence analysis of the Saccharomyces cerevisiae RAD4 gene required for excision repair of UV-damaged DNA
7. Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23
8. DNA repair defect in xeroderma pigmentosum group C and complementing factor from HeLa cells
9. HHR23B, a human Rad23 homolog, stimulates XPC protein in nucleotide excision repair in vitro
10. Identification and characterization of XPC-binding domain of hHR23B
11. Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair
12. DNA repair in active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall
13. Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene
14. The residual repair capacity of xeroderma pigmentosum complementation group C fibroblasts is highly specific for transcriptionally active DNA
15. Xeroderma pigmentosum complementation group C cells remove pyrimidine dimers selectively from the transcribed strand of active genes
16. Overproduction, purification, and characterization of the XPC subunit of the human DNA repair excision nuclease
17. Assembly, subunit composition, and footprint of human DNA repair excision nuclease
18. Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair
19. Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites
20. Mammalian DNA nucleotide excision repair reconstituted with purified protein components
21. Reconstitution of human DNA repair excision nuclease in a highly defined system
22. RPA involvement in the damage-recognition and incision steps of nucleotide excision repair
23. DNA repair protein XPA binds replication protein A (RPA)
24. The XPA protein is a zinc metalloprotein with an ability to recognize various kinds of DNA-damage
25. An affinity of human replication protein A for ultraviolet-damaged DNA
26. Diversity of the damage recognition step in the global genome nucleotide excision repair in vitro
27. A multistep damage recognition mechanism for global genomic nucleotide excision repair
28. Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II
29. Interactions of the transcription/DNA repair factor TFIIH and XP repair proteins with DNA lesions in a cell-free repair assay
30. The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNA
31. Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome
32. Open complex formation around a lesion during nucleotide excision repair provides a structure for cleavage by human XPG protein
33. Mechanism of open complex and dual incision formation by human nucleotide excision repair factors
34. The non-catalytic function of XPG protein during dual incision in human nucleotide excision repair
35. Characterization of reaction intermediates of human excision repair nuclease
36. Rapid and efficient site-specific mutagenesis without phenotype selection
37. Cell-free repair of UV-damaged simian virus 40 chromosomes in human cell extracts. Part I. Development of a cell-free system detecting excision repair of UV-irradiated SV40 chromosomes
38. Complementation of the xeroderma pigmentosum DNA repair defect in cell-free extracts
39. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
40. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
41. Reconstitution of damage DNA excision reaction from SV40 minichromosomes with purified nucleotide excision repair proteins
42. XPC interacts with HHR23B and HHR23A in vivo
43. DNA damage recognition by XPA protein promotes efficient recruitment of transcription factor IIH
44. Characterization of molecular defects in xeroderma pigmentosum group C
45. Xeroderma pigmentosum group C splice mutation associated with autism and hypoglycinemia
46. Mutation in the XPC gene in families with xeroderma pigmentosum and consequences at the cell, protein, and transcript levels
47. The xeroderma pigmentosum group C gene leads to selective repair of cyclobutane pyrimidine dimers rather than 6-4 photoproducts