Pro-angiogenic activity of astragaloside IV in HUVECs in vitro and zebrafish in vivo

Molecular Medicine Reports

Volumn 5, Issue 3, 2012, Pages 805-811

  Zhang, Yi ^a   Hu, Guang ^a   Li, Shang ^a   Li, Zhen Hua ^a   Lam, Che Oi ^a   Hong, Si Jia ^a   Kwan, Yiu Wa ^b   Chan, Shun Wan ^c   Leung, George Pak Heng ^d   Lee, Simon Ming Yuen ^a  

^a University of Macau   (Macao)

^b Prince of Wales Hospital   (Hong Kong)

^c HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Angiogenesis; Astragaloside IV; Human umbilical vein endothelial cell; Radix astragali; Zebrafish

Indexed keywords

ASTRAGALOSIDE IV; ENHANCED GREEN FLUORESCENT PROTEIN; MATRIGEL; MESSENGER RNA; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; SEMAXANIB; SH 6; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; ASSAY; BLOOD VESSEL INJURY; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL SIZE; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING; WOUND HEALING; ZEBRA FISH;

ANGIOGENESIS INDUCING AGENTS; ANIMALS; ASTRAGALUS PLANT; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; DRUGS, CHINESE HERBAL; GENE EXPRESSION REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INDOLES; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHATIDYLINOSITOLS; PROTO-ONCOGENE PROTEINS C-AKT; PYRROLES; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; SAPONINS; TRITERPENES; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; ZEBRAFISH;

DANIO RERIO;

EID: 84863042713     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2011.716     Document Type: Article

References (21)

1. Kahn J, Mehraban F, Ingle G, et al: Gene expression profiling in an in vitro model of angiogenesis. Am J Pathol 156: 1887-1900, 2000. (Pubitemid 30641758)
2. Milkiewicz M, Ispanovic E, Doyle JL and Haas TL: Regulators of angiogenesis and strategies for their therapeutic manipulation. Int J Biochem Cell Biol 38: 333-357, 2006. (Pubitemid 41821882)
3. Blázquez C, González-Feria L, Alvarez L, Haro A, Casanova ML and Guzmán M: Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. Cancer Res 64: 5617-5623, 2004.
4. Ferrara N: Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 25: 581-611, 2004.
5. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R and Zeiher AM: Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399: 601-605, 1999.
6. Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A and Sessa WC: Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399: 597-601, 1999.
7. Luo Y, Qin Z, Hong Z, Zhang X, Ding D, Fu JH, Zhang WD and Chen J: Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia. Neurosci Lett 363: 218-223, 2004. (Pubitemid 38746516)
8. Zhang C, Wang XH, Zhong MF, Liu RH, Li HL, Zhang WD and Chen H: Mechanisms underlying vasorelaxant action of astragaloside IV in isolated rat aortic rings. Clin Exp Pharmacol Physiol 34: 387-392, 2007. (Pubitemid 46494462)
9. Zhang Y, Hu G, Lin HC, Hong SJ, Deng YH, Tang JY, Seto SW, Kwan YW, Waye MM, Wang YT and Lee SM: Radix Astragali extract promotes angiogenesis involving vascular endothelial growth factor receptor-related phosphatidylinositol 3-kinase/Akt-dependent pathway in human endothelial cells. Phytother Res 23: 1205-1213, 2009.
10. Westerfield, M: A Guide for the Laboratory Use of Zebrafish (Danio rerio). The Zebrafish Book, 5th edition. University of Oregon Press, Eugene, 2007.
11. Merchan JR, Chan B, Kale S, Schnipper LE and Sukhatme VP: In vitro and in vivo induction of antiangiogenic activity by plasminogen activators and captopril. J Natl Cancer Inst 95: 388-399, 2003. (Pubitemid 36395259)
12. Sato Y and Rifkin DB: Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis. J Cell Biol 107: 1199-1205, 1988.
13. Risau W: Mechanisms of angiogenesis. Nature 386: 671-674, 1997.
14. Isner JM: Arterial gene transfer of naked DNA for therapeutic angiogenesis: early clinical results. Adv Drug Deliv Rev 30: 185-197, 1998.
15. Xiong Y, Huo Y, Chen C, Zeng H, Lu X, Wei C, Ruan C, Zhang X, Hu Z, Shibuya M and Luo J: Vascular endothelial growth factor (VEGF) receptor-2 tyrosine 1175 signaling controls VEGF-induced von Willebrand factor release from endothelial cells via phospholipase C-gamma 1- and protein kinase A-dependent pathways. J Biol Chem 284: 23217-23224, 2009.
16. Lam HW, Lin HC, Lao SC, Gao JL, Hong SJ, Leong CW, Yue PY, Kwan YW, Leung AY, Wang YT and Lee SM: The angiogenic effects of Angelica sinensis extract on HUVEC in vitro and zebrafish in vivo. J Cell Biochem 103: 195-211, 2008.
17. Hong SJ, Wan JB, Zhang Y, Hu G, Lin HC, Seto SW, Kwan YW, Lin ZX, Wang YT and Lee SM: Angiogenic effect of saponin extract from Panax notoginseng on HUVECs in vitro and zebrafish in vivo. Phytother Res 23: 677-686, 2009.
18. Sengupta S, Toh SA, Sellers LA, Skepper JN, Koolwijk P, Leung HW, Yeung HW, Wong RN, Sasisekharan R and Fan TP: Modulating angiogenesis: the yin and the yang in ginseng. Circulation 110: 1219-1225, 2004. (Pubitemid 39202336)
19. Tang JY, Li S, Li ZH, Zhang ZJ, Hu G, Cheang LC, Alex D, Hoi MP, Kwan YW, Chan SW, Leung GP and Lee SM: Calycosin promotes angiogenesis involving estrogen receptor and mitogen-activated protein kinase (MAPK) signaling pathway in zebrafish and HUVEC. PLoS One 5: e11822, 2010.
20. Tanimoto T, Jin ZG and Berk BC: Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS). J Biol Chem 277: 42997-43001, 2002. (Pubitemid 35285679)
21. Ahmad S, Hewett PW, Wang P, Al-Ani B, Cudmore M, Fujisawa T, Haigh JJ, le Noble F, Wang L, Mukhopadhyay D and Ahmed A: Direct evidence for endothelial vascular endothelial growth factor receptor-1 function in nitric oxide-mediated angiogenesis. Circ Res 99: 715-722, 2006. (Pubitemid 44498305)