Case studies of minimizing nonspecific inhibitors in HTS campaigns that use assay-ready plates

Journal of Biomolecular Screening

Volumn 17, Issue 2, 2012, Pages 225-236

  Liu, Yichin ^a   Beresini, Maureen H ^a   Johnson, Adam ^a   Mintzer, Robert ^a   Shah, Kinjalkumar ^a   Clark, Kevin ^a   Schmidt, Stephen ^a   Lewis, Cristina ^a   Liimatta, Marya ^a   Elliott, Linda O ^a   Gustafson, Amy ^a   Heise, Christopher E ^a  

^a GENENTECH INC   (United States)

Author keywords

assay ready plates; false positive; high throughput screening; hit rate; nonspecific inhibition

Indexed keywords

CARRIER PROTEIN;

ARTICLE; ENZYME ASSAY; FALSE POSITIVE RESULT; HIGH THROUGHPUT SCREENING; PRIORITY JOURNAL;

ANIMALS; CASPASE 6; CATTLE; COMPUTER SIMULATION; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; FALSE POSITIVE REACTIONS; GAMMA-GLOBULINS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MODELS, THEORETICAL; PEPTIDE HYDROLASES; PROTEIN KINASES; SERUM ALBUMIN; SMALL MOLECULE LIBRARIES;

EID: 84863028421     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057111421525     Document Type: Article

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