Acetylsalicylic acid regulates overexpressed small GTPase RhoA in vascular smooth muscle cells through prevention of new synthesis and enhancement of protein degradation

Bioscience Reports

Volumn 32, Issue 2, 2012, Pages 153-160

  Li, Dong Bo ^a   Fu, Zhi Xuan ^a   Ruan, Shu Qin ^a   Hu, Shen Jiang ^a   Li, Xia ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Acetylsalicylic acid (aspirin); Cyclo oxygenase (COX); Lipopolysaccharide (LPS); Nitric oxide; Small GTPase; Smooth muscle cell

Indexed keywords

ACETYLSALICYLIC ACID; CYCLIC GMP DEPENDENT PROTEIN KINASE; GUANYLATE CYCLASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; NITRIC OXIDE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ARTICLE; CELLULAR STRESS RESPONSE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; INTRACELLULAR SIGNALING; MALE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; RAT; RHOA GENE; VASCULAR SMOOTH MUSCLE;

ANIMALS; ASPIRIN; CYCLIC GMP-DEPENDENT PROTEIN KINASES; CYCLOOXYGENASE INHIBITORS; GUANYLATE CYCLASE; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NITRIC OXIDE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RHOA GTP-BINDING PROTEIN; UP-REGULATION;

RATTUS;

EID: 84863022210     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20110050     Document Type: Article

References (39)

1. Monobe, H., Yamanari, H., Nakamura, K. and Ohe, T. (2001) Effects of low-dose aspirin on endothelial function in hypertensive patients. Clin. Cardiol 24, 705-709 (Pubitemid 33027553)
2. Ranke, C., Hecker, H., Creutzig, A. and Alexander, K. (1993) Dose-dependent effect of aspirin on carotid atherosclerosis. Circulation 87, 1873-1879 (Pubitemid 23165629)
3. Kodama, M., Yamasaki, Y., Sakamoto, K., Yoshioka, R., Matsuhisa, M., Kajimoto, Y., Kosugi, K., Ueda, N. and Hori, M. (2000) Antiplatelet drugs attenuate progression of carotid intima-media thickness in subjects with type 2 diabetes. Thromb. Res. 97, 239-245 (Pubitemid 30069713)
4. Cyrus, T., Sung, S., Zhao, L., Funk, C. D., Tang, S. and Praticò, D. (2002) Effect of low-dose aspirin on vascular inflammation, plaque stability, and atherogenesis in low-density lipoprotein receptor-deficient mice. Circulation 106, 1282-1287 (Pubitemid 34988649)
5. Husain, S., Andrews, N. P., Mulcahy, D., Panza, J. A. and Quyyumi, A. A. (1998) Aspirin improves endothelial dysfunction in atherosclerosis. Circulation 97, 716-720 (Pubitemid 28135332)
6. Wu, R., Lamontagne, D. and de Champlain, J. (2002) Antioxidative properties of acetylsalicylic acid on vascular tissues from normotensive and spontaneously hypertensive rats. Circulation 105, 387-392 (Pubitemid 34106190)
7. Steer, K. A., Wallace, T. M., Bolton, C. H. and Hartog, M. (1997) Aspirin protects low density lipoprotein from oxidative modification. Heart 77, 333-337 (Pubitemid 27208173)
8. Johnson, A. G., Nguyen, T. V. and Day, R. O. (1994) Do nonsteroidal anti-inflammatory drugs affect blood pressure? A meta-analysis. Ann. Intern. Med. 121, 289-300
9. Wilson, S. L. and Poulter, N. R. (2006) The effect of non-steroidal anti-inflammatory drugs and other commonly used non-narcotic analgesics on blood pressure level in adults. J. Hypertens. 24, 1457-1469 (Pubitemid 44162444)
10. Chan, A. T., Manson, J. E., Albert, C. M., Chae, C. U., Rexrode, K. M., Curhan, G. C., Rimm, E. B., Willett, W. C. and Fuchs, C. S. (2006) Nonsteroidal antiinflammatory drugs, acetaminophen, and the risk of cardiovascular events. Circulation 113, 1578-1587 (Pubitemid 43739417)
11. Hermida, R. C., Ayala, D. E., Calvo, C. and López, J. E. (2005) Aspirin administered at bedtime, but not on awakening, has an effect on ambulatory blood pressure in hypertensive patients. J. Am. Coll. Cardiol. 46, 975-983 (Pubitemid 41316502)
12. Hermida, R. C., Ayala, D. E., Calvo, C., López, J. E., Mojón, A., Rodríguez, M. and Fernández, J. R. (2005) Differing administration time-dependent effects of aspirin on blood pressure in dipper and non-dipper hypertensives. Hypertension 46, 1060-1068
13. Etienne-Manneville, S. and Hall, A. (2002) Rho GTPases in cell biology. Nature 420, 629-635 (Pubitemid 36764489)
14. Mallat, Z., Gojova, A., Sauzeau, V., Brun, V., Silvestre, J. S., Esposito, B., Merval, R., Groux, H., Loirand, G. and Tedgui, A. (2003) Rho-associated protein kinase contributes to early atherosclerotic lesion formation in mice. Circ. Res. 93, 884-888 (Pubitemid 37363063)
15. Sawada, N., Itoh, H., Ueyama, K., Yamashita, J., Doi, K., Chun, T. H., Inoue, M., Masatsugu, K., Saito, T., Fukunaga, Y. et al. (2000) Inhibition of Rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries. Circulation 101, 2030-2033 (Pubitemid 30233164)
16. Hyvelin, J. M., Howell, K., Nichol, A., Costello, C. M., Preston, R. J. and McLoughlin, P. (2005) Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation. Circ. Res. 97, 185-191 (Pubitemid 41033475)
17. Uehata, M., Ishizaki, T., Satoh, H., Ono, T., Kawahara, T., Morishita, T., Tamakawa, H., Yamagami, K., Inui, J., Maekawa, M. and Narumiya, S. (1997) Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389, 990-994 (Pubitemid 27485693)
18. Higashi, M., Shimokawa, H., Hattori, T., Hiroki, J., Mukai, Y., Morikawa, K., Ichiki, T., Takahashi, S. and Takeshita, A. (2003) Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase system. Circ. Res. 93, 767-775 (Pubitemid 37288672)
19. Abe, K., Shimokawa, H., Morikawa, K., Uwatoku, T., Oi, K., Matsumoto, Y., Hattori, T., Nakashima, Y., Kaibuchi, K., Sueishi, K. and Takeshit, A. (2004) Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Circ. Res. 94, 385-393 (Pubitemid 38240731)
20. Miyata, K., Shimokawa, H., Kandabashi, T., Higo, T., Morishige, K., Eto, Y., Egashira, K., Kaibuchi, K. and Takeshita, A. (2000) Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivo. Arterioscler. Thromb. Vasc. Biol. 20, 2351-2358
21. Sauzeau, V., Rolli-Derkinderen, M., Marionneau, C., Loirand, G. and Pacaud, P. (2003) RhoA expression is controlled by nitric oxide through cGMP-dependent protein kinase activation. J. Biol. Chem. 278, 9472-9480 (Pubitemid 36800439)
22. 2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol. Rev. 83, 1325-1358
23. Nishio, E. and Watanabe, Y. (1998) Aspirin and salicylate enhances the induction of inducible nitric oxide synthase in cultured rat smooth muscle cells. Life Sci. 63, 429-439 (Pubitemid 28358107)
24. Amin, A. R., Vyas, P., Attur, M., Leszczynska-Piziak, J., Patel, I. R., Weissmann, G. and Abramson, S. B. (1995) The mode of action of aspirin-like drugs: effect on inducible nitric oxide synthase. Proc. Natl. Acad. Sci. U.S. A. 92, 7926-7930
25. Nelin, L. D., Thomas, C. J. and Dawson, C. A. (1996) Effect of hypoxia on nitric oxide production in neonatal pig lung. Am. J. Physiol. 271, H8-H14
26. Hunter, J. C., Zeidan, A., Javadov, S., Kilić, A., Rajapurohitam, V. and Karmazyn, M. (2009) Nitric oxide inhibits endothelin-1-induced neonatal cardiomyocyte hypertrophy via a RhoA-ROCK-dependent pathway. J. Mol. Cell. Cardiol. 47, 810-818
27. Soliman, H., Craig, G. P., Nagareddy, P., Yuen, V. G., Lin, G., Kumar, U., McNeill, J. H. and Macleod, K. M. (2008) Role of inducible nitric oxide synthase in induction of RhoA expression in hearts from diabetic rats. Cardiovasc. Res. 79, 322-330 (Pubitemid 351951610)
28. Burch, J. W. and Blazer-Yost, B. (1981) Acetylation of albumin by low doses of aspirin. Thromb. Res. 23, 447-452 (Pubitemid 12237818)
29. Green, F. A. and Jung, C. Y. (1981) Acetylation of erythrocytic membrane peptides by aspirin. Transfusion 21, 55-58 (Pubitemid 12207712)
30. Hun-Opfer, C. and Mata-Segreda, J. F. (1986) Non-enzymatic acetylation of proteins by aspirin as protection against the secondary complications of diabetes mellitus. Acta Physiol. Pharmacol. Ther. Latinoam. 36, 313-316 (Pubitemid 17192361)
31. Sauzeau, V., Rolli-Derkinderen, M., Lehoux, S., Loirand, G. and Pacaud, P. (2003) Sildenafil prevents change in RhoA expression induced by chronic hypoxia in rat pulmonary artery. Circ. Res. 93, 630-637 (Pubitemid 37222159)
32. Backlund, Jr, P. S. (1997) Post-translational processing of RhoACarboxyl methylation of the carboxyl-terminal prenylcysteine increases the half-life of RhoA. J. Biol. Chem. 272, 33175-33180 (Pubitemid 28023663)
33. Engel, M. E., Datta, P. K. and Moses, H. L. (1998) RhoB is stabilized by transforming growth factor β and antagonizes transcriptional activation. J. Biol. Chem. 273, 9921-9926 (Pubitemid 28183091)
34. Stamatakis, K., Cernuda-Morollón, E., Hernández-Perera, O. and Pérez-Sala, D. (2002) Isoprenylation of RhoB is necessary for its degradation. A novel determinant in the complex regulation of RhoB expression by the mevalonate pathway. J. Biol. Chem. 277, 49389-49396 (Pubitemid 36014371)
35. Lanning, C. C., Daddona, J. L., Ruiz-Velasco, R., Shafer, S. H. and Williams, C. L. (2004) The Rac1 C-terminal polybasic region regulates the nuclear localization and protein degradation of Rac1. J. Biol. Chem. 279, 44197-44210 (Pubitemid 39390727)
36. Pop, M., Aktories, K. and Schmidt, G. (2004) Isotype-specific degradation of Rac activated by the cytotoxic necrotizing factor 1. J. Biol. Chem. 279, 35840-35848 (Pubitemid 39100591)
37. Rolli-Derkinderen, M., Sauzeau, V., Boyer, L., Lemichez, E., Baron, C., Henrion, D., Loirand, G. and Pacaud, P. (2005) Phosphorylation of serine 188 protects RhoA from ubiquitin/proteasome-mediated degradation in vascular smooth muscle cells. Circ. Res. 96, 1152-1160 (Pubitemid 40827690)
38. Awtry, E. H. and Loscalzo, J. (2000) Aspirin. Circulation 101, 1206-1218 (Pubitemid 30146625)
39. Feldman, M. and Cryer, B. (1999) Aspirin absorption rates and platelet inhibition times with 325-mg buffered aspirin tablets (chewed or swallowed intact) and with buffered aspirin solution. Am. J. Cardiol. 84, 404-409 (Pubitemid 29398659)