-
1
-
-
0027123107
-
Molecular and cellular biology of blood coagulation
-
Furie B, Furie BC. Molecular and cellular biology of blood coagulation. N Engl J Med 1992;326:800-6.
-
(1992)
N Engl J Med
, vol.326
, pp. 800-806
-
-
Furie, B.1
Furie, B.C.2
-
2
-
-
0036690114
-
Drugs targeting the renin-angiotensin-aldosterone system
-
DOI 10.1038/nrd873
-
Zaman MA, Oparil S, Calhoun DA. Drugs targeting the renin-angiotensin- aldosterone system. Nat Rev Drug Discov 2002;1:621-36. (Pubitemid 37368827)
-
(2002)
Nature Reviews Drug Discovery
, vol.1
, Issue.8
, pp. 621-636
-
-
Zaman, M.A.1
Oparil, S.2
Calhoun, D.A.3
-
3
-
-
0034681260
-
Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
-
Brown MS, Ye J, Rawson RB, Goldstein JL. Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell 2000;100:391-8.
-
(2000)
Cell
, vol.100
, pp. 391-398
-
-
Brown, M.S.1
Ye, J.2
Rawson, R.B.3
Goldstein, J.L.4
-
4
-
-
0034517112
-
Proteolysis and developmental signal transduction
-
DOI 10.1006/scdb.2000.0167
-
Ye Y, Fortini ME. Proteolysis and developmental signal transduction. Semin Cell Dev Biol 2000;11:211-21. (Pubitemid 32095014)
-
(2000)
Seminars in Cell and Developmental Biology
, vol.11
, Issue.3
, pp. 211-221
-
-
Ye, Y.1
Fortini, M.E.2
-
5
-
-
0032575750
-
Caspases: Enemies within
-
Thornberry NA, Lazebnik Y. Caspases: enemies within. Science 1998;281:1312-6. (Pubitemid 28406817)
-
(1998)
Science
, vol.281
, Issue.5381
, pp. 1312-1316
-
-
Thornberry, N.A.1
Lazebnik, Y.2
-
7
-
-
0038242360
-
Proteolytic processing is necessary to separate and ensure proper cell growth and cytokinesis functions of HCF-1
-
DOI 10.1093/emboj/cdg242
-
Julien E, Herr W. Proteolytic processing is necessary to separate and ensure proper cell growth and cytokinesis functions of HCF-1. EMBOJ 2003;22:2360-9. (Pubitemid 36604975)
-
(2003)
EMBO Journal
, vol.22
, Issue.10
, pp. 2360-2369
-
-
Julien, E.1
Herr, W.2
-
8
-
-
33748269854
-
Proteolysis of MLL family proteins is essential for Taspase1-orchestrated cell cycle progression
-
DOI 10.1101/gad.1449406
-
Takeda S, Chen DY, Westergard TD, Fisher JK, Rubens JA, Sasagawa S, et al. Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression. Genes Dev 2006;20:2397-409. (Pubitemid 44320388)
-
(2006)
Genes and Development
, vol.20
, Issue.17
, pp. 2397-2409
-
-
Takeda, S.1
Chen, D.Y.2
Westergard, T.D.3
Fisher, J.K.4
Rubens, J.A.5
Sasagawa, S.6
Kan, J.T.7
Korsmeyer, S.J.8
Cheng, E.H.-Y.9
Hsieh, J.J.-D.10
-
11
-
-
2342613652
-
The proteasome: A suitable antineoplastic target
-
Adams J. The proteasome: a suitable antineoplastic target. Nat Rev Cancer 2004;4:349-60. (Pubitemid 38579481)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.5
, pp. 349-360
-
-
Adams, J.1
-
12
-
-
0028806725
-
A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection
-
Markowitz M, Saag M, Powderly WG, Hurley AM, Hsu A, Valdes JM, et al. A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection. N Engl J Med 1995;333:1534-9.
-
(1995)
N Engl J Med
, vol.333
, pp. 1534-1539
-
-
Markowitz, M.1
Saag, M.2
Powderly, W.G.3
Hurley, A.M.4
Hsu, A.5
Valdes, J.M.6
-
13
-
-
0345276803
-
Taspase1: A threonine aspartase required for cleavage of MLL and proper HOX gene expression
-
DOI 10.1016/S0092-8674(03)00816-X
-
Hsieh JJ, Cheng EH, Korsmeyer SJ. Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression. Cell 2003;115:293-303. (Pubitemid 37487703)
-
(2003)
Cell
, vol.115
, Issue.3
, pp. 293-303
-
-
Hsieh, J.J.-D.1
Cheng, E.H.-Y.2
Korsmeyer, S.J.3
-
14
-
-
26444542870
-
Crystal structure of human taspase1, a crucial protease regulating the function of MLL
-
DOI 10.1016/j.str.2005.07.006, PII S0969212605002650
-
Khan JA, Dunn BM, Tong L. Crystal structure of human Taspase1, a crucial protease regulating the function of MLL. Structure 2005;13:1443-52. (Pubitemid 41427584)
-
(2005)
Structure
, vol.13
, Issue.10
, pp. 1443-1452
-
-
Khan, J.A.1
Dunn, B.M.2
Tong, L.3
-
15
-
-
0037215399
-
Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization
-
DOI 10.1128/MCB.23.1.186-194.2003
-
Hsieh JJ, Ernst P, Erdjument-Bromage H, Tempst P, Korsmeyer SJ. Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization. Mol Cell Biol 2003;23:186-94. (Pubitemid 36008512)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.1
, pp. 186-194
-
-
Hsieh, J.J.-D.1
Ernst, P.2
Erdjument-Bromage, H.3
Tempst, P.4
Korsmeyer, S.J.5
-
16
-
-
33645238594
-
Uncleaved TFIIA is a substrate for taspase 1 and active in transcription
-
Zhou H, Spicuglia S, Hsieh JJ, Mitsiou DJ, Hoiby T, Veenstra GJ, et al. Uncleaved TFIIA is a substrate for taspase 1 and active in transcription. Mol Cell Biol 2006;26:2728-35.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 2728-2735
-
-
Zhou, H.1
Spicuglia, S.2
Hsieh, J.J.3
Mitsiou, D.J.4
Hoiby, T.5
Veenstra, G.J.6
-
17
-
-
0033520327
-
Structural insights into the mechanism of intramolecular proteolysis
-
DOI 10.1016/S0092-8674(00)80052-5
-
Xu Q, Buckley D, Guan C, Guo HC. Structural insights into the mechanism of intramolecular proteolysis. Cell 1999;98:651-61. (Pubitemid 29418956)
-
(1999)
Cell
, vol.98
, Issue.5
, pp. 651-661
-
-
Xu, Q.1
Buckley, D.2
Guan, C.3
Guo, H.-C.4
-
18
-
-
35148901465
-
Species selectivity of mixed-lineage leukemia/trithorax and HCF proteolytic maturation pathways
-
DOI 10.1128/MCB.00769-07
-
Capotosti F, Hsieh JJ, Herr W. Species selectivity of mixed lineage leukemia/trithorax and HCF proteolytic maturation pathways. Mol Cell Biol 2007;27:7063-72. (Pubitemid 47549745)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.20
, pp. 7063-7072
-
-
Capotosti, F.1
Hsieh, J.J.-D.2
Herr, W.3
-
19
-
-
79551661274
-
OGlcNAc transferase catalyzes site-specific proteolysis of HCF-1
-
Capotosti F, Guernier S, Lammers F, Waridel P, Cai Y, Jin J, et al. OGlcNAc transferase catalyzes site-specific proteolysis of HCF-1. Cell 2011;144:376-88.
-
(2011)
Cell
, vol.144
, pp. 376-388
-
-
Capotosti, F.1
Guernier, S.2
Lammers, F.3
Waridel, P.4
Cai, Y.5
Jin, J.6
-
20
-
-
77954382362
-
Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis
-
Chen DY, Liu H, Takeda S, Tu HC, Sasagawa S, Van Tine BA, et al. Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis. Cancer Res 2010;70:5358-67.
-
(2010)
Cancer Res
, vol.70
, pp. 5358-5367
-
-
Chen, D.Y.1
Liu, H.2
Takeda, S.3
Tu, H.C.4
Sasagawa, S.5
Van Tine, B.A.6
-
21
-
-
41349084350
-
EPS15R, TASP1, and PRPF3 Are Novel Disease Candidate Genes Targeted by HNF4alpha Splice Variants in Hepatocellular Carcinomas
-
DOI 10.1053/j.gastro.2008.01.027, PII S0016508508001017
-
Niehof M, Borlak J. EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas. Gastroenterology 2008;134:1191-202. (Pubitemid 351451974)
-
(2008)
Gastroenterology
, vol.134
, Issue.4
, pp. 1191-1202
-
-
Niehof, M.1
Borlak, J.2
-
22
-
-
44649135084
-
Gene expression profile analysis of primary glioblastomas and non-neoplastic brain tissue: Identification of potential target genes by oligonucleotide microarray and real-time quantitative PCR
-
Scrideli CA, Carlotti CG Jr, Okamoto OK, Andrade VS, Cortez MA, Motta FJ, et al. Gene expression profile analysis of primary glioblastomas and non-neoplastic brain tissue: identification of potential target genes by oligonucleotide microarray and real-time quantitative PCR. J Neurooncol 2008;88:281-91.
-
(2008)
J Neurooncol
, vol.88
, pp. 281-291
-
-
Scrideli, C.A.1
Carlotti Jr., C.G.2
Okamoto, O.K.3
Andrade, V.S.4
Cortez, M.A.5
Motta, F.J.6
-
23
-
-
0023713558
-
Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene
-
Muller WJ, Sinn E, Pattengale PK, Wallace R, Leder P. Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell 1988;54:105-15.
-
(1988)
Cell
, vol.54
, pp. 105-115
-
-
Muller, W.J.1
Sinn, E.2
Pattengale, P.K.3
Wallace, R.4
Leder, P.5
-
24
-
-
0024162530
-
Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice
-
Tsukamoto AS, Grosschedl R, Guzman RC, Parslow T, Varmus HE. Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell 1988;55:619-25.
-
(1988)
Cell
, vol.55
, pp. 619-625
-
-
Tsukamoto, A.S.1
Grosschedl, R.2
Guzman, R.C.3
Parslow, T.4
Varmus, H.E.5
-
25
-
-
23144448901
-
Real-time imaging of ligand-induced IKK activation in intact cells and in living mice
-
DOI 10.1038/nmeth779
-
Gross S, Piwnica-Worms D. Real-time imaging of ligand-induced IKK activation in intact cells and in living mice. Nat Methods 2005;2:607-14. (Pubitemid 41086852)
-
(2005)
Nature Methods
, vol.2
, Issue.8
, pp. 607-614
-
-
Gross, S.1
Piwnica-Worms, D.2
-
26
-
-
77956944025
-
Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint
-
Liu H, Takeda S, Kumar R, Westergard TD, Brown EJ, Pandita TK, et al. Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint. Nature 2010;467:343-6.
-
(2010)
Nature
, vol.467
, pp. 343-346
-
-
Liu, H.1
Takeda, S.2
Kumar, R.3
Westergard, T.D.4
Brown, E.J.5
Pandita, T.K.6
-
27
-
-
0034534795
-
Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis
-
DOI 10.1126/science.290.5497.1761
-
Zha J, Weiler S, Oh KJ, Wei MC, Korsmeyer SJ. Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis. Science 2000;290:1761-5. (Pubitemid 32004806)
-
(2000)
Science
, vol.290
, Issue.5497
, pp. 1761-1765
-
-
Zha, J.1
Weiler, S.2
Oh, K.J.3
Wei, M.C.4
Korsmeyer, S.J.5
-
28
-
-
78649700978
-
BID, BIM, and PUMA are essential for activation of the BAX- And BAK-dependent cell death program
-
Ren D, Tu HC, Kim H, Wang GX, Bean GR, Takeuchi O, et al. BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program. Science 2010;330:1390-3.
-
(2010)
Science
, vol.330
, pp. 1390-1393
-
-
Ren, D.1
Tu, H.C.2
Kim, H.3
Wang, G.X.4
Bean, G.R.5
Takeuchi, O.6
-
30
-
-
0037111567
-
Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties
-
DOI 10.1182/blood-2002-04-1015
-
Yokoyama A, Kitabayashi I, Ayton PM, Cleary ML, Ohki M. Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties. Blood 2002;100:3710-8. (Pubitemid 35303943)
-
(2002)
Blood
, vol.100
, Issue.10
, pp. 3710-3718
-
-
Yokoyama, A.1
Kitabayashi, I.2
Ayton, P.M.3
Cleary, M.L.4
Ohki, M.5
-
31
-
-
0004135644
-
-
San Francisco, California; W H Freeman & Company
-
Walsh CT. Enzymatic reaction mechanisms. San Francisco, California; W H Freeman & Company: 1978.
-
(1978)
Enzymatic Reaction Mechanisms
-
-
Walsh, C.T.1
-
33
-
-
68349148051
-
Design, syntheses, and evaluation of Taspase1 inhibitors
-
Lee JT, Chen DY, Yang Z, Ramos AD, Hsieh JJ, Bogyo M. Design, syntheses, and evaluation of Taspase1 inhibitors. Bioorg Med Chem Lett 2009;19:5086-90.
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 5086-5090
-
-
Lee, J.T.1
Chen, D.Y.2
Yang, Z.3
Ramos, A.D.4
Hsieh, J.J.5
Bogyo, M.6
-
34
-
-
33749011163
-
The NCI60 human tumour cell line anticancer drug screen
-
DOI 10.1038/nrc1951, PII NRC1951
-
Shoemaker RH. The NCI60 human tumour cell line anticancer drug screen. Nat Rev Cancer 2006;6:813-23. (Pubitemid 44450469)
-
(2006)
Nature Reviews Cancer
, vol.6
, Issue.10
, pp. 813-823
-
-
Shoemaker, R.H.1
-
35
-
-
84872596016
-
-
Bethesda (MD): The National Cancer Institute. c1990-[cited 2011 Nov 9]. Available from
-
Developmental therapeutics program [Internet]. Bethesda (MD): The National Cancer Institute. c1990-[cited 2011 Nov 9]. Available from: http://dtp.nci.nih.gov/
-
Developmental Therapeutics Program [Internet]
-
-
-
36
-
-
55749092457
-
Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion
-
Saunders LP, Ouellette A, Bandle R, Chang WC, Zhou H, Misra RN, et al. Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion. Mol Cancer Ther 2008;7:3352-62.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3352-3362
-
-
Saunders, L.P.1
Ouellette, A.2
Bandle, R.3
Chang, W.C.4
Zhou, H.5
Misra, R.N.6
-
37
-
-
0025968042
-
Regulation of Phosphorylation of the c-erbB-2/HER2 Gene Product by a Monoclonal Antibody and Serum Growth Factor(s) in Human Mammary Carcinoma Cells
-
Kumar R, Shepard HM, Mendelsohn J. Regulation of phosphorylation of the c-erbB-2/HER2 gene product by a monoclonal antibody and serum growth factor(s) in human mammary carcinoma cells. Mol Cell Biol 1991;11:979-86. (Pubitemid 21895448)
-
(1991)
Molecular and Cellular Biology
, vol.11
, Issue.2
, pp. 979-986
-
-
Kumar, R.1
Shepard, H.M.2
Mendelsohn, J.3
-
38
-
-
0038488950
-
A multigenic program mediating breast cancer metastasis to bone
-
DOI 10.1016/S1535-6108(03)00132-6
-
Kang Y, Siegel PM, Shu W, Drobnjak M, Kakonen SM, Cordon-Cardo C, et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 2003;3:537-49. (Pubitemid 36808649)
-
(2003)
Cancer Cell
, vol.3
, Issue.6
, pp. 537-549
-
-
Kang, Y.1
Siegel, P.M.2
Shu, W.3
Drobnjak, M.4
Kakonen, S.M.5
Cordon-Cardo, C.6
Guise, T.A.7
Massague, J.8
-
39
-
-
0020003085
-
7 cells: Correlation between binding to estrogen receptor and inhibition of cell growth
-
Coezy E, Borgna JL, Rochefort H. Tamoxifen and metabolites in MCF7 cells: correlation between binding to estrogen receptor and inhibition of cell growth. Cancer Res 1982;42:317-23. (Pubitemid 12207285)
-
(1982)
Cancer Research
, vol.42
, Issue.1
, pp. 317-323
-
-
Coezy, E.1
Borgna, J.L.2
Rochefort, H.3
-
40
-
-
61449182121
-
Principles of cancer therapy: Oncogene and non-oncogene addiction
-
Luo J, Solimini NL, Elledge SJ. Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 2009;136:823-37.
-
(2009)
Cell
, vol.136
, pp. 823-837
-
-
Luo, J.1
Solimini, N.L.2
Elledge, S.J.3
-
41
-
-
34548658230
-
Heat Shock Factor 1 Is a Powerful Multifaceted Modifier of Carcinogenesis
-
DOI 10.1016/j.cell.2007.07.020, PII S0092867407009579
-
Dai C, Whitesell L, Rogers AB, Lindquist S. Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell 2007;130:1005-18. (Pubitemid 47410269)
-
(2007)
Cell
, vol.130
, Issue.6
, pp. 1005-1018
-
-
Dai, C.1
Whitesell, L.2
Rogers, A.B.3
Lindquist, S.4
-
42
-
-
47049120726
-
IRF4 addiction in multiple myeloma
-
DOI 10.1038/nature07064, PII NATURE07064
-
Shaffer AL, Emre NC, Lamy L, Ngo VN, Wright G, Xiao W, et al. IRF4 addiction in multiple myeloma. Nature 2008;454:226-31. (Pubitemid 351969894)
-
(2008)
Nature
, vol.454
, Issue.7201
, pp. 226-231
-
-
Shaffer, A.L.1
Emre, N.C.T.2
Lamy, L.3
Ngo, V.N.4
Wright, G.5
Xiao, W.6
Powell, J.7
Dave, S.8
Yu, X.9
Zhao, H.10
Zeng, Y.11
Chen, B.12
Epstein, J.13
Staudt, L.M.14
-
43
-
-
41649102043
-
The cancer biomarker problem
-
DOI 10.1038/nature06913, PII NATURE06913
-
Sawyers CL. The cancer biomarker problem. Nature 2008;452:548-52. (Pubitemid 351483368)
-
(2008)
Nature
, vol.452
, Issue.7187
, pp. 548-552
-
-
Sawyers, C.L.1
|