TFF3 mediated induction of VEGF via hypoxia in human gastric cancer SGC-7901 cells

Molecular Biology Reports

Volumn 39, Issue 4, 2012, Pages 4127-4134

  Guleng, Bayasi ^a   Han, Jia ^a   Yang, Jin Qiu ^a   Huang, Qing Wen ^a   Huang, Jian Kun ^a   Yang, Xiao Ning ^a   Liu, Jing Jing ^a   Ren, Jian Lin ^a  

^a XIAMEN UNIVERSITY   (China)

Author keywords

HIF 1a; Hypoxia; TFF3; VEGF

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; PHOSGENE; PUROMYCIN; TREFOIL FACTOR 3; TUMOR PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; PEPTIDE; TFF3 PROTEIN, HUMAN; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ARTICLE; CANCER CELL CULTURE; CELL HYPOXIA; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPOXIA INDUCIBLE FACTOR 1ALPHA GENE; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SECRETION; RNA INTERFERENCE; STOMACH CANCER; TUMOR GENE; UPREGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR GENE; GENETICS; METABOLISM; STOMACH TUMOR; TUMOR CELL LINE;

CELL HYPOXIA; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; PEPTIDES; RNA, MESSENGER; STOMACH NEOPLASMS; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84863006539     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-011-1195-2     Document Type: Article

References (30)

1. Lazar D, Raica M, Sporea I, Taban S, Goldis A (2006) Cornianu M: Tumor angiogenesis in gastric cancer. Rom J Morphol Embryol 47(1):5-13
2. Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV et al (2004) Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med 10(2): 145-147
3. Lyden D, Hattori K, Dias S, Costa C, Blaikie P, Butros L, Chadburn A, Heissig B, Marks W, Witte L et al (2001) Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Med 7(11):1194-1201
4. Guleng B, Tateishi K, Ohta M, Kanai F, Jazag A, Ijichi H, Tanaka Y, Washida M, Morikane K, Fukushima Y (2005) Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner. Cancer Res 65(13):5864-5871
5. Carmeliet P (2000) Collen D: Molecular basis of angiogenesis Role of VEGF and VE-cadherin. Ann NY Acad Sci 902:249-262 Discussion 262-244
6. Carmeliet P (2003) Angiogenesis in health and disease. Nat Med 9(6):653-660
7. Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P et al (1998) Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394(6692): 485-490
8. Yanyan C, Guoxian Q, Yang G, Leting W (2008) Mechanism of hypoxia-induced factor 1alpha expression in endothelial cells of the human umbilical vein and its induction of apoptosis. Mol Biol Rep 35(3):285-290
9. Jiang BH, Semenza GL, Bauer C, Marti HH (1996) Hypoxiainducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. Am J Physiol 271(4 Pt 1): C1172-C1180
10. Lemus-Varela ML, Flores-Soto ME, Cervantes-Munguia R, Torres-Mendoza BM, Gudino-Cabrera G, Chaparro-Huerta V, Ortuno-Sahagun D, Beas-Zarate C (2010) Expression of HIF-1alpha, VEGF and EPO in peripheral blood from patients with two cardiac abnormalities associated with hypoxia. Clin Biochem 43(3):234-239
11. Meyer zum Buschenfelde D, Hoschutzky H, Tauber R, Huber O (2004) Molecular mechanisms involved in TFF3 peptide-mediated modulation of the E-cadherin/catenin cell adhesion complex. Peptides 25(5):873-883
12. Podolsky DK (2000) Mechanisms of regulatory peptide action in the gastrointestinal tract: Trefoil peptides. J Gastroenterol 35(Suppl 12):69-74
13. Emami S, Rodrigues S, Rodrigue CM, Le Floch N, Rivat C, Attoub S, Bruyneel E, Gespach C (2004) Trefoil factor family (TFF) peptides and cancer progression. Peptides 25(5):885-898
14. Rivat C, Rodrigues S, Bruyneel E, Pietu G, Robert A, Redeuilh G, Bracke M, Gespach C, Attoub S (2005) Implication of STAT3 signaling in human colonic cancer cells during intestinal trefoil factor 3 (TFF3)-And vascular endothelial growth factor-mediated cellular invasion and tumor growth. Cancer Res 65(1): 195-202
15. Furuta GT, Turner JR, Taylor CT, Hershberg RM, Comerford K, Narravula S, Podolsky DK, Colgan SP (2001) Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia. J Exp Med 193(9):1027-1034
16. Louis NA, Hamilton KE, Canny G, Shekels LL, Ho SB, Colgan SP (2006) Selective induction of mucin-3 by hypoxia in intestinal epithelia. J Cell Biochem 99(6):1616-1627
17. Hernandez C, Santamatilde E, McCreath KJ, Cervera AM, Diez I, Ortiz-Masia D, Martinez N, Calatayud S, Esplugues JV, Barrachina MD (2009) Induction of trefoil factor (TFF)1, TFF2 and TFF3 by hypoxia is mediated by hypoxia inducible factor-1: Implications for gastric mucosal healing. Br J Pharmacol 156(2): 262-272
18. Liu FQ, Liu Y, Lui VC, Lamb JR, Tam PK, Chen Y (2008) Hypoxia modulates lipopolysaccharide induced TNF-Alpha expression in murine macrophages. Exp Cell Res 314(6): 1327-1336
19. Miyagishi M, Taira K (2002) U6 promoter-driven siRNAs with four uridine 30 overhangs efficiently suppress targeted gene expression in mammalian cells. Nat Biotechnol 20(5):497-500
20. Jazag A, Ijichi H, Kanai F, Imamura T, Guleng B, Ohta M, Imamura J, Tanaka Y, Tateishi K, Ikenoue T et al (2005) Smad4 silencing in pancreatic cancer cell lines using stable RNA interference and gene expression profiles induced by transforming growth factor-beta. Oncogene 24(4):662-671
21. Guleng B, Tateishi K, Kanai F, Jazag A, Ohta M, Asaoka Y, Ijichi H, Tanaka Y, Imamura J, Ikenoue T et al (2005) Cancerderived VEGF plays no role in malignant ascites formation in the mouse. World J Gastroenterol 11(35):5455-5459
22. Shirato K, Kizaki T, Sakurai T, Ogasawara JE, Ishibashi Y, Iijima T, Okada C, Noguchi I, Imaizumi K, Taniguchi N et al (2009) Hypoxia-inducible factor-1alpha suppresses the expression of macrophage scavenger receptor 1. Pflugers Arch 459(1):93-103
23. Emami S, Le Floch N, Bruyneel E, Thim L, May F, Westley B, Rio M, Mareel M, Gespach C (2001) Induction of scattering and cellular invasion by trefoil peptides in src-And RhoA-Transformed kidney and colonic epithelial cells. Faseb J 15(2):351-361
24. Baus-Loncar M, Giraud AS (2005) Multiple regulatory pathways for trefoil factor (TFF) genes. Cell Mol Life Sci 62(24):2921-2931
25. Loboda A, Jozkowicz A, Dulak J (2010) HIF-1 and HIF-2 transcription factors-similar but not identical. Mol Cells 29(5): 435-442
26. Cummins EP, Taylor CT (2005) Hypoxia-responsive transcription factors. Pflugers Arch 450(6):363-371
27. De Maria R, Zeuner A, Eramo A, Domenichelli C, Bonci D, Grignani F, Srinivasula SM, Alnemri ES, Testa U, Peschle C (1999) Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1. Nature 401(6752):489-493
28. Kramer MF, Gunaratne P, Ferreira GC (2000) Transcriptional regulation of the murine erythroid-specific 5-Aminolevulinate synthase gene. Gene 247(1-2):153-166
29. Tarumoto T, Imagawa S, Ohmine K, Nagai T, Higuchi M, Imai N, Suzuki N, Yamamoto M, Ozawa K (2000) N(G)-monomethyl-L-Arginine inhibits erythropoietin gene expression by stimulating GATA-2. Blood 96(5):1716-1722
30. Chu SH, Feng DF, Ma YB, Zhu ZA, Zhang H, Qiu JH (2009) Stabilization of hepatocyte growth factor mRNA by hypoxiainducible factor 1. Mol Biol Rep 36(7):1967-1975