Association of polymorphisms in transforming growth factor-b receptors with susceptibility to gastric cardia adenocarcinoma

Molecular Biology Reports

Volumn 39, Issue 4, 2012, Pages 4301-4309

  Guo, Wei ^a   Dong, Zhiming ^a   Guo, Yanli ^a   Chen, Zhifeng ^a   Yang, Zhibin ^a   Kuang, Gang ^a  

^a Medical University   (China)

Author keywords

Gastric cardia adenocarcinoma; Polymorphism; Transforming growth factor b receptor I; Transforming growth factor b receptor II

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; PROTEIN SERINE THREONINE KINASE; TGF BETA TYPE I RECEPTOR; TGF-BETA TYPE I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ALLELE; ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CARDIA CARCINOMA; CASE CONTROL STUDY; CHINA; CONTROLLED STUDY; DISEASE ASSOCIATION; FAMILY HISTORY; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; RECEPTOR GENE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; STOMACH ADENOCARCINOMA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR I GENE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR II GENE; ADENOCARCINOMA; CARDIA; GENETIC PREDISPOSITION; GENETICS; METABOLISM; PATHOLOGY; STOMACH TUMOR;

ADENOCARCINOMA; CARDIA; CASE-CONTROL STUDIES; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOHISTOCHEMISTRY; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; STOMACH NEOPLASMS;

EID: 84863000433     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-011-1217-0     Document Type: Article

References (32)

1. Attisano L, Wrana JL (2002) Signal transduction by the TGF-b superfamily. Science 296:1646-1647
2. Beck C, Schreiber H, Rowley D (2001) Role of TGF-beta in immune-evasion of cancer. Microsc Res Tech 52:387-395
3. Derynck R, Akhurst RJ, Balmain A (2001) TGF-beta signaling in tumor suppression and cancer progression. Nat Genet 29:117-129
4. Shi Y, Massague J (2003) Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113:685-700
5. Dumont N, Arteaga CL (2002) The tumor microenvironment: A potential arbitrator of the tumor suppressive and promoting actions of TGF beta. Differentiation 70:574-582
6. Pasche B, Kolachana P, Nafa K et al (1999) TbetaR-I (6A) is a candidate tumor susceptibility allele. Cancer Res 59:5678-5682
7. Pasche B, Knobloch TJ, Bian Y et al (2005) Somatic acquisition and signaling of TGFbRI*6A in Cancer. JAMA 294: 1634-1646
8. Skoglund J, Song B, Dalén J et al (2007) Lack of an association between the TGFBR1*6A variant and colorectal cancer risk. Clin Cancer Res 13:3748-3752
9. Kaklamani V, Baddi L, Rosman D et al (2004) No major association between TGFBR1*6A and prostate cancer. BMC Genet 5:28
10. You W, Liu Z, Zhao J et al (2007) No association between TGFBR1*6A and lung cancer. J Thorac Oncol 2:657-659
11. Castillejo A, Rothman N, Murta-Nascimento C et al (2009) TGFB1 and TGFBR1 polymorphic variants in relationship to bladder cancer risk and prognosis. Int J Cancer 124:608-613
12. Chen T, Jackson C, Costello B et al (2004) An intronic variant of the TGFBR1 gene is associated with carcinomas of the kidney and bladder. Int J Cancer 112:420-425
13. Zhang HT, Fei QY, Chen F et al (2003) Mutational analysis of the transforming growth factor beta receptor type I gene in primary non-small cell lung cancer. Lung Cancer 40:281-287
14. Chen T, Jackson CR, Link A et al (2006) Int7G24A variant of transforming growth factor-beta receptor type I is associated with invasive breast cancer. Clin Cancer Res 12:392-397
15. Song B, Margolin S, Skoglund J et al (2007) TGFBR1 (*) 6A and Int7G24A variants of transforming growth factor-beta receptor 1 in Swedish familial and sporadic breast cancer. Br J Cancer 97: 1175-1179
16. Castillejo A, Mata-Balaguer T, Guarinos C et al (2009) The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: A case-control study. BMC Cancer 9:406
17. Skoglund Lundin J, Vandrovcova J, Song B et al (2009) TGFBR1 variants TGFBR1*6A and Int7G24A are not associated with an increased familial colorectal cancer risk. Br J Cancer 100: 1674-1679
18. Hu YS, Pan Y, Li WH et al (2010) Association between TGFBR1*6A and osteosarcoma: a chinese case-control study. BMC Cancer 10:169
19. Hu YS, Pan Y, Li WH, et al. (2010) Int7G24A variant of transforming growth factor-beta receptor 1 is associated with osteosarcoma susceptibility in a Chinese population. Med Oncol (in press)
20. Seijo ER, Song H, Lynch MA et al (2001) Identification of genetic alterations in the TGFbeta type ll receptor gene promoter. Mutat Res 483:19-26
21. Baxter SW, Choong DY, Eccles DM et al (2002) Transforming growth factor beta receptor 1 polyalanine polymorphism and exon 5 mutation analysis in breast and ovarian cancer. Cancer Epidemiol Biomarkers Prev 11:211-214
22. Pasche B, Kaklamani V, Hou N et al (2004) TGFBR1*6A and cancer: A meta-analysis of 12 case-control studies. J Clin Oncol 22:756-758
23. Jin Q, Hemminki K, Grzybowska E et al (2004) Polymorphisms and haplotype structures in genes for transforming growth factor beta1 and its receptors in familial and unselected breast cancers. Int J Cancer 112:94-99
24. Liao RY, Mao C, Qiu LX et al (2010) TGFBR1*6A/9A polymorphism and cancer risk: A meta-analysis of 13, 662 cases and 14, 147 controls. Mol Biol Rep 37:3227-3232
25. Houlston RS, Peto J (2004) The search for low-penetrance cancer susceptibility alleles. Oncogene 23:6471-6476
26. Jin G, Deng Y, Miao R et al (2008) TGFB1 and TGFBR2 functional polymorphisms and risk of esophageal squamous cell carcinoma: A case-control analysis in a Chinese population. J Cancer Res Clin Oncol 134:345-351
27. Jin G, Wang L, Chen W et al (2007) Variant alleles of TGFB1 and TGFBR2 are associated with a decreased risk of gastric cancer in a Chinese population. Int J Cancer 120:1330-1335
28. Pinto M, Oliveira C, Cirnes L et al (2003) Promoter methylation of TGF beta receptor I and mutation of TGF beta receptor II are frequent events in MSI sporadic gastric carcinomas. J Pathol 200:32-38
29. de Carvalho F, Colleoni GW, Almeida MS et al (2009) TGFbetaR2 aberrant methylation is a potential prognostic marker and therapeutic target in multiple myeloma. Int J Cancer 125:1985-1991
30. Ammanamanchi S, Brattain MG (2004) Restoration of transforming growth factor-beta signaling through receptor RI induction by histone deacetylase activity inhibition in breast cancer cells. J Biol Chem 279:32620-32625
31. Osada H, Tatematsu Y, Sugito N et al (2005) Histone modification in the TGFbetaRII gene promoter and its significance for responsiveness to HDAC inhibitor in lung cancer cell lines. Mol Carcinog 44:233-241
32. Sakaguchi J, Kyo S, Kanaya T et al (2005) Aberrant expression and mutations of TGF-beta receptor type II gene in endometrial cancer. Gynecol Oncol 98:427-433