Identification of signalling pathways triggered by changes in the mechanical environment in rat chondrocytes

Osteoarthritis and Cartilage

Volumn 20, Issue 8, 2012, Pages 931-939

  Sanz Ramos, P ^a   Mora, G ^a,b   Ripalda, P ^a   Vicente Pascual, M ^a   Izal Azcarate I ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

Chondrocyte; Collagen hydrogels; Integrins; Mechanosensing; Mechanotransduction

Indexed keywords

AGGRECAN; ALPHA1 INTEGRIN; BETA1 INTEGRIN; BETA3 INTEGRIN; FOCAL ADHESION KINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MYOSIN; PAXILLIN; PROTEIN FOS; PROTEIN KINASE P60; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TRANSCRIPTION FACTOR SOX9;

ANIMAL CELL; ARTICLE; CARTILAGE CELL; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; ENVIRONMENT; GENE EXPRESSION; MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CARTILAGE, ARTICULAR; CHONDROCYTES; FOCAL ADHESION KINASE 1; GENE EXPRESSION; GENES, FOS; GENES, JUN; GENES, SRC; HINDLIMB; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTEGRINS; MYOSIN TYPE II; PAXILLIN; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; SOX9 TRANSCRIPTION FACTOR;

EID: 84862996435     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2012.04.022     Document Type: Article

References (44)

1. Mankin H.J. The response of articular cartilage to mechanical injury. J Bone Jt Surger 1982, 64:460-466.
2. Mandelbaum B.R., Browne J.E., Fu F., Micheli L., Mosely J.B., Erggelet C., et al. Articular cartilage lesions of the knee. Am J Sports Med 1998, 26(6):853-861.
3. Buckwalter J.A., Mankin H.J. Articular cartilage. Degeneration and ostcoarthritis, repair, regeneration and transplantation. Instr Course Lect 1998, 47:487-504.
4. Heberhold C., Faber S., Stammberger T., Steinlechner M., Putz R., Englmeier K.H., et al. In situ measurement of articular cartilage deformation in intact femoropatellar joints under static loading. J Biomech 1999, 32:1287-1295.
5. Ateshian G.A., Kwak S.D., Soslowsky L.J., Mow V.C. A stereophotogrammetric method for determining in situ contact areas in diarthrodial joints, and a comparison with other methods. J Biomech 1994, 27:111-124.
6. Maxian T.A., Brown T.D., Weinstein S.L. Chronic stress tolerance levels for human articular cartilage: two nonuniform contact models applied to long-term follow-up of CDH. J Biomech 1995, 28:159-166.
7. Engler A.J., Sen S., Sweeney H.L., Discher D.E. Matrix elasticity directs stem cell lineage specification. Cell 2006, 126(4):677-689.
8. Bonassar L.J., Grodzinsky A.J., Srinivasan A., Davila S.G., Trippel S.B. Mechanical and physicochemical regulation of the action of IGF-I on articular cartilage. Arch Biochem Biophys 2000, 379(1):57-63.
9. Grodzinsky A.J., Levenston M.E., Jin M., Frank E.H. Cartilage tissue remodeling in response to mechanical forces. Annu Rev Biomed Eng 2000, 2:691-713.
10. Hynes R.O. Integrins: bidirectional, allosteric signaling machines. Cell 2002, 110:673-687.
11. Loeser F.R. Chondrocyte integrin expression and function. Biorheology 2000, 37(1-2):109-116.
12. Loeser F.R. Integrins and cell signaling in chondrocytes. Biorheology 2002, 39(1-2):119-124.
13. Shakibaei M., Csaki C., Mobasheri A. Diverse roles of integrin receptors in articular cartilage. Adv Anat Embryol Cell Biol 2008, 197:1-60.
14. Millward-Sadler S.J., Salter D.M. Integrin-dependent signal cascades in chondrocyte mechanotransduction. Ann Biomed Eng 2004, 32(3):435-446.
15. Hanks S.K., Calalb M.B., Harper M.C., Patel S.K. Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. Proc Natl Acad Sci USA 1992, 89:8487-8491.
16. Schaller M.D., Borgman C.A., Cobb B.S., Vines R.R., Reynolds A.B., Parsons J.T. pp125FAK, a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc Natl Acad Sci USA 1992, 89:5192-5196.
17. Xing Z., Chen H.C., Nowlen J.K., Taylor S.J., Shalloway D., Guan J.L. Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain. Mol Biol Cell 1994, 5:413-421.
18. Polte T.R., Hanks S.K. Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas. Proc Natl Acad Sci USA 1995, 92:10678-10682.
19. Benya P.D., Shaffer J.D. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell 1982, 30:215-224.
20. Darling E.M., Athanasiou K.A. Rapid phenotypic changes in passaged articular chondrocyte subpopulations. J Orthop Res 2005, 23(2):425-432.
21. Henrotin Y., Kurz B., Aigner T. Oxygen and reactive oxygen species in cartilage degradation: friends or foes?. Osteoarthritis Cartilage 2005, 13(8):643-654.
22. Murphy C.L., Thoms B.L., Vaghjiani R.J., Lafont J.E. Hypoxia. HIF-mediated articular chondrocyte function: prospects for cartilage repair. Arthritis Res Ther 2009, 11(1):213.
23. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25(4):402-408.
24. Acosta C., Izal I., Ripalda P., Douglas-Price A.L., Forriol F. Gene expression and proliferation analysis in young, aged, and osteoarthritic sheep chondrocytes effect of growth factor treatment. J Orthop Res 2006, 24(11):2087-2094.
25. Schuh E., Kramer J., Rohwedel J., Notbohm H., Müller R., Gutsmann T., et al. Effect of matrix elasticity on the maintenance of the chondrogenic phenotype. Tissue Eng Part A 2010, 16:1281-1290.
26. Schuh E., Hofmann S., Stok K.S., Notbohm H., Müller R., Rotter N. The influence of matrix elasticity on chondrocyte behavior in 3D. J Tissue Eng Regen Med 2011.
27. Park J.S., Chu J.S., Tsou A.D., Diop R., Tang Z., Wang A., et al. The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-β. Biomaterials 2011, 32:3921-3930.
28. Krendel M., Mooseker M.S. Myosins: tails (and heads) of 42 functional diversity. Physiology (Bethesda) 2005, 20:239-251.
29. Clark K., Langeslaq M., Figdor C.G., van Leeuwen F.N. Myosin II and mechanotransduction: a balancing act. Trends Cel Biol 2007, 17(4):178-186.
30. Balaban N.Q., Schwarz U.S., Riveline D., Goichberg P., Tzur G., Sabanay I., et al. Force and focal adhesion assembly: a close relationship studied using elastic micro- patterned substrates. Nat Cell Biol 2001, 3:466-472.
31. Norman J.C., Jones D., Barry S.T., Holt M.R., Cockcroft S., Critchley D.R. ARF1 mediates paxillin recruitment to focal adhesions and potentiates Rho-stimulated stress fiber formation in intact and permeabilized Swiss 3T3 fibroblasts. J Cell Biol 1998, 143:1981-1995.
32. Narumiya S., Ishizaki T., Watanabe N. Rho effectors and reorganization of actin cytoskeleton. FEBS Lett 1997, 410:68-72.
33. Damianova R., Stefanova N., Cukierman E., Momchilova A., Pankov R. Three-dimensional matrix induces sustained activation of ERK1/2 via Src/Ras/Raf signaling pathway. Cell Biol Int 2008, 32(2):229-234.
34. Glowacki J., Trepman E., Folkman J. Cell shape and phenotypic expression in chondrocytes. Proc Soc Exp Biol Med 1983, 172:93-98.
35. Brodkin K.R., García A.J., Levenston M.E. Chondrocyte phenotypes on different extracellular matrix monolayers. Biomaterials 2004, 25:5929-5938.
36. Wright E., Hargrave M.R., Christiansen J., Cooper L., Kun J., Evans T., et al. The Sry-related gene Sox9 is CREB expressed during chondrogenesis in mouse embryos. Nat Gen 1995, 9:15-20.
37. Kumar A., Knox A.J., Boriek A.M. CCAAT/enhancer-binding protein and activator protein-1 transcription factors regulate the expression of interleukin-8 through the mitogen-activated protein kinase pathways in response to mechanical stretch of human airway smooth muscle cells. J Biol Chem 2003, 278:18868-18876.
38. Peake M.A., El Haj A.J. Preliminary characterisation of mechanoresponsive regions of the c-fos promoter in bone cells. FEBS Lett 2003, 537:117-120.
39. Peverali F.A., Basdra E.K., Papavassiliou A.G. Stretch-mediated activation of selective MAPK subtypes and potentiation of AP-1 binding in human osteoblastic cells. Mol Med 2001, 7:768-778.
40. De Croos J.N., Dhaliwal S.S., Grynpas M.D., Pilliar R.M., Kandel R.A. Cyclic compressive mechanical stimulation induces sequential catabolic and anabolic gene changes in chondrocytes resulting in increased extracellular matrix accumulation. Matrix Biol 2006, 25:323-331.
41. De Croos J.N., Pilliar R.M., Kandel R.A. AP-1 DNA binding activity regulates the cartilage tissue remodeling process following cyclic compression in vitro. Biorheology 2008, 45(3-4):459-469.
42. Fanning P.J., Emkey G., Smith R.J., Grodzinsky A.J., Szasz N., Trippel S.B. Mechanical regulation of mitogen-activated protein kinase signaling in articular cartilage. J Biol Chem 2003, 278:50940-50948.
43. Lefebvre V., Huang W., Harley V.R., Goodfellow P.N., Crombrugghe B. SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene. Mol Cell Biol 1997, 17:2336-2346.
44. Bell D.M., Leung K.K., Wheatley S.C., Nq L.J., Zhou S., Ling K.W., et al. SOX9 directly regulates the type-II collagen gene. Nat Gen 1997, 16:174-178.