GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Baloucoune, Guillaume A ^a   Chun, Lei ^a   Zhang, Wenhua ^a   Xu, Chanjuan ^a   Huang, Siluo ^a   Sun, Qian ^a   Wang, Yunyun ^a   Tu, Haijun ^a   Liu, Jianfeng ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; BACLOFEN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOLIPASE C; SOMATOMEDIN C RECEPTOR; PRIMER DNA;

APOPTOSIS; ARTICLE; CELL SURFACE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NERVE CELL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TRANSACTIVATION; ANIMAL; CELL MEMBRANE; CELL STRAIN HEK293; CHEMISTRY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; METABOLISM; MOUSE; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; PHYSIOLOGY; POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

MUS;

ANIMALS; BASE SEQUENCE; CELL MEMBRANE; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEK293 CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; RECEPTOR, IGF TYPE 1; RECEPTORS, GABA-B; RNA INTERFERENCE; TRANSCRIPTIONAL ACTIVATION;

EID: 84862993893     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039698     Document Type: Article

References (36)

1. Kaupmann K, Huggel K, Heid J, Flor PJ, Bischoff S, et al. (1997) Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature 386: 239-246.
2. Couve A, Moss SJ, Pangalos MN, (2000) GABAB receptors: a new paradigm in G protein signaling. Mol Cell Neurosci 16: 296-312.
3. Kaupmann K, Malitschek B, Schuler V, Heid J, Froestl W, et al. (1998) GABA(B)-receptor subtypes assemble into functional heteromeric complexes. Nature 396: 683-687.
4. Jones KA, Borowsky B, Tamm JA, Craig DA, Durkin MM, et al. (1998) GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2. Nature 396: 674-679.
5. White JH, Wise A, Main MJ, Green A, Fraser NJ, et al. (1998) Heterodimerization is required for the formation of a functional GABA(B) receptor. Nature 396: 679-682.
6. Kuner R, Kohr G, Grunewald S, Eisenhardt G, Bach A, et al. (1999) Role of heteromer formation in GABAB receptor function. Science 283: 74-77.
7. Cao J, Huang S, Qian J, Huang J, Jin L, et al. (2009) Evolution of the class C GPCR Venus flytrap modules involved positive selected functional divergence. BMC Evol Biol 9: 67.
8. Galvez T, Duthey B, Kniazeff J, Blahos J, Rovelli G, et al. (2001) Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function. EMBO J 20: 2152-2159.
9. Margeta-Mitrovic M, Jan YN, Jan LY, (2001) Function of GB1 and GB2 subunits in G protein coupling of GABA(B) receptors. Proc Natl Acad Sci U S A 98: 14649-14654.
10. Margeta-Mitrovic M, Jan YN, Jan LY, (2000) A trafficking checkpoint controls GABA(B) receptor heterodimerization. Neuron 27: 97-106.
11. Calver AR, Robbins MJ, Cosio C, Rice SQ, Babbs AJ, et al. (2001) The C-terminal domains of the GABA(b) receptor subunits mediate intracellular trafficking but are not required for receptor signaling. J Neurosci 21: 1203-1210.
12. Giorelli M, Livrea P, Defazio G, Ricchiuti F, Pagano E, et al. (2001) IFN-beta1a modulates the expression of CTLA-4 and CD28 splice variants in human mononuclear cells: induction of soluble isoforms. J Interferon Cytokine Res 21: 809-812.
13. Lujan R, Shigemoto R, Lopez-Bendito G, (2005) Glutamate and GABA receptor signalling in the developing brain. Neuroscience 130: 567-580.
14. Calver AR, Medhurst AD, Robbins MJ, Charles KJ, Evans ML, et al. (2000) The expression of GABA(B1) and GABA(B2) receptor subunits in the cNS differs from that in peripheral tissues. Neuroscience 100: 155-170.
15. Isomoto S, Kaibara M, Sakurai-Yamashita Y, Nagayama Y, Uezono Y, et al. (1998) Cloning and tissue distribution of novel splice variants of the rat GABAB receptor. Biochem Biophys Res Commun 253: 10-15.
16. Schwarz DA, Barry G, Eliasof SD, Petroski RE, Conlon PJ, et al. (2000) Characterization of gamma-aminobutyric acid receptor GABAB(1e), a GABAB(1) splice variant encoding a truncated receptor. J Biol Chem 275: 32174-32181.
17. Wei K, Eubanks JH, Francis J, Jia Z, Snead OC 3rd (2001) Cloning and tissue distribution of a novel isoform of the rat GABA(B)R1 receptor subunit. Neuroreport 12: 833-837.
18. Clark JA, Mezey E, Lam AS, Bonner TI, (2000) Distribution of the GABA(B) receptor subunit gb2 in rat CNS. Brain Res 860: 41-52.
19. Gassmann M, Shaban H, Vigot R, Sansig G, Haller C, et al. (2004) Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice. J Neurosci 24: 6086-6097.
20. Vanhoose AM, Emery M, Jimenez L, Winder DG, (2002) ERK activation by G-protein-coupled receptors in mouse brain is receptor identity-specific. J Biol Chem 277: 9049-9053.
21. Tu H, Rondard P, Xu C, Bertaso F, Cao F, et al. (2007) Dominant role of GABAB2 and Gbetagamma for GABAB receptor-mediated-ERK1/2/CREB pathway in cerebellar neurons. Cell Signal 19: 1996-2002.
22. Tu H, Xu C, Zhang W, Liu Q, Rondard P, et al. (2010) GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation. J Neurosci 30: 749-759.
23. Franek M, Pagano A, Kaupmann K, Bettler B, Pin JP, et al. (1999) The heteromeric GABA-B receptor recognizes G-protein alpha subunit C-termini. Neuropharmacology 38: 1657-1666.
24. Dong AQ, Kong MJ, Ma ZY, Qian JF, Xu XH, (2007) Down-regulation of IGF-IR using small, interfering, hairpin RNA (siRNA) inhibits growth of human lung cancer cell line A549 in vitro and in nude mice. Cell Biol Int 31: 500-507.
25. Binet V, Brajon C, Le Corre L, Acher F, Pin JP, et al. (2004) The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor. J Biol Chem 279: 29085-29091.
26. Richer M, David M, Villeneuve LR, Trieu P, Ethier N, et al. (2009) GABA-B(1) receptors are coupled to the ERK1/2 MAP kinase pathway in the absence of GABA-B(2) subunits. J Mol Neurosci 38: 67-79.
27. David M, Richer M, Mamarbachi AM, Villeneuve LR, Dupre DJ, et al. (2006) Interactions between GABA-B1 receptors and Kir 3 inwardly rectifying potassium channels. Cell Signal 18: 2172-2181.
28. Nakamura Y, Hinoi E, Takarada T, Takahata Y, Yamamoto T, et al. (2011) Positive regulation by GABA(B)R1 subunit of leptin expression through gene transactivation in adipocytes. PLoS One 6: e20167.
29. Villemure JF, Adam L, Bevan NJ, Gearing K, Chenier S, et al. (2005) Subcellular distribution of GABA(B) receptor homo- and hetero-dimers. Biochem J 388: 47-55.
30. Kantamneni S, Correa SA, Hodgkinson GK, Meyer G, Vinh NN, et al. (2007) GISP: a novel brain-specific protein that promotes surface expression and function of GABA(B) receptors. J Neurochem 100: 1003-1017.
31. Balasubramanian S, Teissere JA, Raju DV, Hall RA, (2004) Hetero-oligomerization between GABAA and GABAB receptors regulates GABAB receptor trafficking. J Biol Chem 279: 18840-18850.
32. Laviv T, Vertkin I, Berdichevsky Y, Fogel H, Riven I,et al. Compartmentalization of the GABAB receptor signaling complex is required for presynaptic inhibition at hippocampal synapses. J Neurosci 31: 12523-12532.
33. Lin X, Li X, Jiang M, Chen L, Xu C, et al. (2012) An activity-based probe reveals dynamic protein-protein interactions mediating IGF-1R transactivation by the GABAB receptor. Biochem J 443: 627-634.
34. Rives ML, Vol C, Fukazawa Y, Tinel N, Trinquet E, et al. (2009) Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration. EMBO J 28: 2195-2208.
35. Prosser HM, Gill CH, Hirst WD, Grau E, Robbins M, et al. (2001) Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice. Mol Cell Neurosci 17: 1059-1070.
36. Duthey B, Caudron S, Perroy J, Bettler B, Fagni L, et al. (2002) A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor. J Biol Chem 277: 3236-3241.