Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Gunton, Jenny E ^a,b,c,d   Sisavanh, Mary ^a   Stokes, Rebecca A ^a,b   Satin, Jon ^e   Satin, Leslie S ^f,i   Zhang, Min ^f   Liu, Sue M ^a   Cai, Weikang ^e   Cheng, Kim ^a,b   Cooney, Gregory J ^a   Laybutt, D Ross ^a   So, Trina ^a   Molero, Juan Carlos ^a   Grey, Shane T ^a   Andres, Douglas A ^e   Rolph, Michael S ^g   Mackay, Charles R ^h  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c University of Sydney   (Australia)

^d WESTMEAD HOSPITAL   (Australia)

^e UNIVERSITY OF KENTUCKY   (United States)

^f VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g GRIFFITH UNIVERSITY   (Australia)

^h MONASH UNIVERSITY   (Australia)

ⁱ UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CALCIUM CHANNEL; GEM GUANOSINE TRIPHOSPHATASE; GLUCOSE; GUANOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL FUNCTION; CONTROLLED STUDY; ENZYME DEFICIENCY; ENZYME REGULATION; EXPERIMENTAL MOUSE; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; IN VIVO STUDY; INSULIN RELEASE; INSULIN TOLERANCE TEST; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PHENOTYPE; PROTEIN FUNCTION;

ANIMALS; CALCIUM; CALCIUM SIGNALING; GLUCOSE; GLUCOSE INTOLERANCE; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MICE; MICE, KNOCKOUT; MONOMERIC GTP-BINDING PROTEINS;

MUS;

EID: 84862990419     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039462     Document Type: Article

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