Gene augmentation trials using the Rpe65-deficient dog: Contributions towards development and refinement of human clinical trials

Advances in Experimental Medicine and Biology

Volumn 723, Issue , 2012, Pages 177-182

  Petersen Jones, Simon M ^a   Annear, Matthew J ^a   Bartoe, Joshua T ^a   Mowat, Freya M ^a   Barker, Susie E ^b   Smith, Alexander J ^b   Bainbridge, James W ^b   Ali, Robin R ^b  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

AAV2; Briard; Canine Model; Gene Augmentation; Gene Therapy; Immune Response; Leber Congenital Amaurosis; Repeated Injection; RPE65; Subretinal Injection

Indexed keywords

GROWTH FACTOR; PARVOVIRUS VECTOR; RETINA PIGMENT EPITHELIUM PROTEIN 65; UNCLASSIFIED DRUG;

CONFERENCE PAPER; DOG; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; GENE; GENE EXPRESSION; GENE THERAPY; HUMAN; LEBER CONGENITAL AMAUROSIS; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA DEGENERATION; RPE65 GENE; SPONTANEOUS MUTATION; TRANSGENE; VIRAL GENE THERAPY;

ANIMALS; CARRIER PROTEINS; CLINICAL TRIALS, PHASE I AS TOPIC; CLINICAL TRIALS, PHASE II AS TOPIC; DISEASE MODELS, ANIMAL; DOGS; EYE PROTEINS; GENE THERAPY; HUMANS; LEBER CONGENITAL AMAUROSIS;

CANIS FAMILIARIS;

EID: 84862960633     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-0631-0_24     Document Type: Conference Paper

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