Safety and efficacy of intravitreal injection of recombinant erythropoietin for protection of photoreceptor cells in a rat model of retinal detachment

Eye

Volumn 26, Issue 1, 2012, Pages 144-152

  Xie, Z ^a,b,c   Chen, F ^a,b   Wu, X ^c   Zhuang, C ^a,b   Zhu, J ^a,b   Wang, J ^a,b   Ji, H ^a,b   Wang, Y ^a,b   Hua, X ^a,b  

^a YANGZHOU UNIVERSITY   (China)

^b NORTHERN JIANGSU PEOPLE S HOSPITAL   (China)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

apoptosis; erythropoietin; flash electroretinogram; retinal detachment experimental

Indexed keywords

CASPASE 3; PROTEIN BCL XL; RECOMBINANT ERYTHROPOIETIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; ELECTRORETINOGRAM; ENZYME ACTIVATION; ENZYME REPRESSION; EXPERIMENTAL MODEL; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; MALE; NONHUMAN; PHOTORECEPTOR CELL; PROTEIN EXPRESSION; RAT; RETINA; RETINA DETACHMENT; RETINA OUTER NUCLEAR LAYER; THICKNESS; TISSUE STRUCTURE; WESTERN BLOTTING;

EID: 84862958521     PISSN: 0950222X     EISSN: 14765454     Source Type: Journal    
DOI: 10.1038/eye.2011.254     Document Type: Article

References (34)

1. Jelkmann W, Metzen E. Erythropoietin in the control of red cell production. Ann Anat 1996; 178: 391-403. (Pubitemid 26364568)
2. Rex TS, Allocca M, Domenic L, Surace EM, Maguire AM, Lyubarsky A et al. Systemic but not intraocular EPO gene transfer protects the retina from light- and genetic-induced degeneration. Mol Thr 2004; 10: 855-861. (Pubitemid 39419912)
3. Grimm C, Wenzel A, Stanescu D, Samardzija M, Hotop S, Groszer M et al. Constitutive overexpression of human erythropoietin protects the mouse retina against induced but not inherited retinal degeneration. J Neurosci 2004; 24: 5651-5658. (Pubitemid 38857219)
4. Girmm C, Wenzel A, Groazer M, Mayser H, Seeliger M, Samardzija M et al. HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration. Nat Med 2002; 8: 718-724. (Pubitemid 34778725)
5. Rex TS, Wong Y Kodali K, Merry S. Neuroprotection of photoreceptors by direct delivery of erythropoietin to the retina of the retinal degeneration slow mouse. Exp Eye Res 2009; 89: 735-740.
6. Junk AK, Mammis A, Savitz SI, Singh M, Roth S, Malhotra S et al. Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury. Proc Natl Acad Sci USA 2002; 99: 10659-10664.
7. Fu QL, Wu W, Wang H, Li X, Lee VW, So KF. Up-regulated endogenous erythropoietin /erythropoietin receptor system and exogenous erythropoietin rescue retinal ganglion cells after chronic ocular hypertension. Cell Mol Neurobiol 2008; 28: 317-329. (Pubitemid 351253068)
8. Tsai JC, Wu L, Worgul B, Forbes M, Cao J. Intravitreal administration of erythropoietin and preservation of retinal ganglion cells in an experimental rat model of glaucoma. Curr Eye Res 2005; 30: 531-538.
9. Tsai JC, Song BJ, Wu L, Forbes M. Erythropoietin: A candidate neuroprotective agent in the treatment of glaucoma. J Glaucoma 2007; 16: 567-571. (Pubitemid 47415215)
10. Weishaupt JH, Rohde G, Pölking E, Siren AL, Ehrenreich H, Bähr M. Effect of erythropoietin axotomy-induced apoptosis in rat retinal ganglion cells. Invest Ophthalmol Vis Sci 2004; 45: 1514-1522. (Pubitemid 38859333)
11. Kilic U, Kilic E, Soliz J, Bassetti CI, Gassmann M, Hermann DM. Erythropoietin protects from axotomy-induced degeneration of retinal ganglion cells by activating ERK-1/-2. FASEB J 2005; 19: 249-251. (Pubitemid 40189271)
12. King CE, Rodger J, Bartlett C, Esmaili T, Dunlop SA, Beazley LD. Erythropoietin is both neuroprotective and neuroregenerative following optic nerve transaction. Exp Eye Res 2007; 205: 48-55. (Pubitemid 46617489)
13. Sättler MB, Merkler D, Maier K, Stadelmann C, Ehrenreich H, Bähr M et al. Neuroprotective effects and intracellular signaling pathways of erythropoietin in a rat model of multiple sclerosis. Cell Death Differ 2004; 11: 181-192.
14. Diem R, Sättler MB, Merkler D, Demmer I, Maier K, Stadelmann C et al. Combined therapy with methylprednisolone and erythropoietin in a model of multiple sclerosis. Brain 2005; 128: 375-385. (Pubitemid 40222606)
15. Zhu B, Wang W, Gu Q, Xu X. Erythropoietin protects retinal neurons and glial cells in early-stage streptozotocin-induced diabetic rats. Exp Eye Res 2008; 86: 375-382.
16. Zhang JF, Wu Y, Jin Y, Ji F, Sinclair SH, Luo Y et al. Intravitreal injection of erythropoietin protects both retinal vascular and neuronal cells in early diabetes. Invest Ophthalmol Vis Sci 2008; 9: 732-742.
17. Shen J, Wu Y, Xu JY Zhang J, Sinclair SH, Yanoff M et al. ERK- and Akt-dependent neuroprotection by erythro-poietin (EPO) against glyoxal-AGEs via modulation of Bcl-xL, Bax, and BAD. Invest Ophthalmol Vis Sci 2010; 51: 35-46.
18. Wang Q, Pfister F, Dorn-Beineke A, vom Hagen F, Lin J, Feng Y et al. Low-dose erythropoietin inhibits oxidative stress and early vascular changes in the experimental diabetic retina. Diabetologia 2010; 53: 1227-1238.
19. Li W, Sinclair SH, Xu GT. Effects of intravitreal erythropoietin therapy for patients with chronic and progressive diabetic macular edema. Ophthalmic Surg Lasers Imaging 2010; 41: 18-25.
20. Chen J, Connor KM, Aderman CM, Smith LE. Erythropoietin deficiency decreases vascular stability in mice. J Clin Invest 2008; 118: 526-533. (Pubitemid 351206543)
21. Patel S, Rowe MJ, Winters SA, Ohls RK. Elevated erythropoietin mRNA and protein concentrations in the developing human eye. Pediatr Res 2008; 63: 394-397. (Pubitemid 351450585)
22. Chung H, Lee H, Lamoke F, Hrushesky WJ, Wood PA, Jahng WJ. Neuroprotective role of erythropoietin by antiapoptosis in the retina. J Neurosci Res 2009; 87: 2365-2374.
23. Juul SE, Yachnis AT, Christensen RD. Tissue distribution of erythropoietin and erythropoietin receptor in the developing human fetus. Early Hum Dev 1998; 52: 235-249. (Pubitemid 28548695)
24. Garća-Raḿrez M, Hernández C, Simó R. Expression of erythropoietin and its receptor in the human retina: a comparative study of diabetic and nondiabetic subjects. Diabetes Care 2008, 31. 1189-1194.
25. Shah SS, Tsang SH, Mahajan VB. Erythropoetin receptor expression in the human diabetic retina. BMC Res Notes 2009; 2: 234.
26. Anderson DH, Guérin CJ, Erickson PA, Stern WH, Fisher SK. Morphological recovery in the reattached retina. Invest Ophthalmol Vis Sci 1986; 27: 168-172.
27. Xie Z, Wu X, Qiu Q, Gong Y Song Y, Gu Q et al. Expression pattern of erythropoietin and erythropoietin receptor in experimental model of retinal detachment. Curr Eye Res 2007; 32: 757-764. (Pubitemid 47450627)
28. Wang ZY, Shen LJ, Zhao KK, Song ZM, Qu J. Elevated erythropoietin in vitreous of patients with rhegmatogenous retinal detachment and proliferative vitreoretinopathy Ophthalmic Res 2009; 42: 138-140.
29. Xie Z, Wu X, Gong Y, Song Y, Qiu Q,LiC. Intraperitoneal injection of Ginkgo Biloba extract (EGb 761) enhances anti-oxidation capability of retina and protects photoreceptors after light-induced retinal damage in rats. Curr Eye Res 2007; 32: 471-479. (Pubitemid 46789423)
30. Takagi H, Watanabe D, Suzuma K, Kurimoto M, Suzuma I, Ohashi H et al. Novel role of erythropoietin in proli-ferative diabetic retinopathy Diabetes Res Clin Pract 2007; 77: S62-S64. (Pubitemid 47212555)
31. Zacks DN, Hänninen V, Pantcheva M, Ezra E, Grosskreutz C, Miller JW. Caspase activiation in an experimental model of retinal detachment. Invest Ophthalmol Vis Sci 2003; 44: 1262-1267. (Pubitemid 36297848)
32. Zacks DN, Zheng QD, Han Y, Bakhru R, Miller JW. FAS-mediated apoptosis and its relation to intrinsic pathway activation in an experimental model of retinal detachment. Invest Ophthalmol Vis Sci 2004; 45: 4563-4569. (Pubitemid 39564684)
33. Berglin L, Algvere PV, Seregard S. Photoreceptor decay over time and apoptosis in experimental retinal detachment. Graefe's Arch Clin Exp Ophthalmol 1997; 235: 306-312. (Pubitemid 27214417)
34. Yang L, Bula D, Arroyo JG, Chen DF. Preventing retinal detachment-associated photoreceptor cell loss in Bax-deficient mice. Invest Ophthalmol Vis Sci 2004; 45: 648-654. (Pubitemid 38140526)