Loperamide, an FDA-Approved antidiarrhea drug, effectively reverses the resistance of multidrug resistant MCF-7/MDR1 human breast cancer cells to doxorubicin-induced cytotoxicity

Cancer Investigation

Volumn 30, Issue 2, 2012, Pages 119-125

  Zhou, Yanfei ^a   Sridhar, Rajagopalan ^a   Shan, Liang ^a   Sha, Wei ^a   Gu, Xinbin ^a   Sukumar, Saraswati ^b  

^a HOWARD UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Breast cancer; Doxorubicin; Loperamide; Multidrug resistance

Indexed keywords

DOXORUBICIN; LOPERAMIDE; MULTIDRUG RESISTANCE PROTEIN 1;

ARTICLE; BREAST CANCER; CANCER CHEMOTHERAPY; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENTIATION; DRUG UPTAKE; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIBIOTICS, ANTINEOPLASTIC; ANTIDIARRHEALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL NUCLEUS; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; FEMALE; HUMANS; LOPERAMIDE; P-GLYCOPROTEIN; RHODAMINE 123; RNA, MESSENGER;

EID: 84862927140     PISSN: 07357907     EISSN: 15324192     Source Type: Journal    
DOI: 10.3109/07357907.2011.640653     Document Type: Article

References (22)

1. Choi C. ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal. Cancer Cell Int 2005;5:30.
2. Clarke R, Currier S, Kaplan O, Lovelace E, Boulay V, Gottesman MM, Dickson RB. Effect of P-glycoprotein expression on sensitivity to hormones in MCF-7 human breast cancer cells. J Natl Cancer Inst 1992;84:1506-1512.
3. Cole SP, Bhardwaj G, Gerlach JH,Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM, Deeley RG. Overexpression of a transporter gene in a multidrug-resistant human lung AM cancer cell line. Science 1992;258:1650-1654. (Pubitemid 23012438)
4. Coley HM. Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer. Cancer Treat Rev 2008;34:378-390.
5. Cox DS, Scott KR, Gao H, Raje S, Eddington ND. Influence of multidrug resistance (MDR) proteins at the blood-brain barrier on the transport and brain distribution of enaminone anticonvulsants. J Pharm Sci 2001;90:1540-1552. (Pubitemid 32979748)
6. Damle BD, Sridhar R, Desai PB. Dipyridamole modulates multidrug resistance and intracellular as well as nuclear levels of doxorubicin in B16 melanoma cells. Int J Cancer 1994;56:113-118. (Pubitemid 24044802)
7. Dean M, Hamon Y, Chimini G. The human ATP-binding cassette (ABC) transporter superfamily. J Lipid Res 2001;42:1007-1017. (Pubitemid 32645780)
8. Fojo T, Coley HM. The role of efflux pumps in drug-resistant metastatic breast cancer: new insights and treatment strategies. Clin Breast Cancer 2007;7:749-756. (Pubitemid 350086119)
9. Gottesman MM, Fojo T, Bates SE. Multidrug resistance in cancer: Role of ATP-dependent transporters. Nat Rev Cancer 2002;2:48-58. (Pubitemid 37328807)
10. Gottesman MM, Ling V. The molecular basis of multidrug resistance in cancer: The early years of P-glycoprotein research. FEBS Lett 2006;580:998-1009. (Pubitemid 43185280)
11. Hoffmeyer S, Burk O, von Richter O, Arnold HP, Brockm̈oller J, JohneA, Cascorbi I, GerloffT, Roots I,EichelbaumM, Brinkmann U. Functional polymorphisms of the humanmultiresistance gene: multiple sequence variations and correlation of one allele with Pglycoprotein expression and activity in vivo. Proc Natl Acad Sci USA 2000;97:3473-3478. (Pubitemid 30183327)
12. Kamel AM, El-Sharkawy N, Yassin D, Shaaban K, Hussein H, SidhomI, Abo El-Naga S, AmeenM, El-Hattab O, Aly El-DinNH. P-gp expression and Rh 123 efflux assay have no impact on survival in Egyptian pediatric acute lymphoblastic leukemia patients. J Egypt Natl Canc Inst 2005;17:165-172.
13. Li J, Xu LZ, He KL, Guo WJ, Zheng YH, Xia P, Chen Y. Reversal effects of nomegestrol acetate on multidrug resistance in adriamycin-resistant MCF7 breast cancer cell line. Breast Cancer Res 2001;3:253-263. (Pubitemid 32633348)
14. Loetchutinat C, Saengkhae C, Marbeuf-Gueye C, Garnier- Suillerot A. New insights into the P-glycoprotein-mediated effluxes of rhodamines. Eur J Biochem 2003;270:476-485. (Pubitemid 36177314)
15. Ludwig JA, SzaḱacsG,MartinSE, ChuBF, Cardarelli C, SaunaZE, Caplen NJ, Fales HM, Ambudkar SV, Weinstein JN, Gottesman MM. Selective toxicity of NSC73306 in MDR1-positive cells as a newstrategy to circumventmultidrug resistance in cancer. Cancer Res 2006;66:4808-4815.
16. Nobili S, Landini I, Giglioni B, Mini E. Pharmacological strategies for overcoming multidrug resistance. Curr Drug Targets 2006;7:861-879.
17. Pauli-Magnus C, Feiner J, Brett C, Lin E, Kroetz DL. No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects. Clin Pharmacol Ther 2003;74:487-498. (Pubitemid 37357727)
18. Weaver JL, Pine PS, Aszalos A, Schoenlein PV, Currier SJ, Padmanabhan R, Gottesman MM Laser scanning and confocal microscopy of daunorubicin, doxorubicin, and rhodamine 123 in multidrug-resistant cells. Exp Cell Res. 1991;196:323-329. (Pubitemid 121006408)
19. Schinkel AH, Wagenaar E, Mol CA, van Deemter L. Pglycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest 1996;97:2517-2524. (Pubitemid 26187339)
20. Skarke C, Jarrar M, Schmidt H, Kauert G, Langer M, Geisslinger G, L̈otsch J. Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers. Pharmacogenetics 2003;13:651-660. (Pubitemid 38316509)
21. Wu J, Lu Y, Lee A, Pan X, Yang X, Zhao X , Lee RJ. Reversal of multidrug resistance by transferrin-conjugated liposomes co-encapsulating doxorubicin and verapamil. J Pharm Pharm Sci 2007;10:350-357. (Pubitemid 350065179)
22. Wandel C, Kim R, Wood M, Wood A. Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein. Anesthesiology 2002; 96:913-920. (Pubitemid 34266685)