A rare variant at the KYNU gene is associated with kynureninase activity and essential hypertension in the Han Chinese population

Circulation: Cardiovascular Genetics

Volumn 4, Issue 6, 2011, Pages 687-694

  Zhang, Yi ^a,b,c   Shen, Jie ^a,c,d   He, Xin ^a,c   Zhang, Kuixing ^a,c   Wu, Shengnan ^a,b,c   Xiao, Bing ^a,c   Zhou, Xueya ^e   Phillips, Robert S ^f   Gao, Pingjin ^a,b,c   Jeunemaitre, Xavier ^a,g   Zhu, Dingliang ^a,b,c  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Chinese Academy of Sciences   (China)

^c Shanghai Institute of Hypertension   (China)

^d ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^e TSINGHUA UNIVERSITY   (China)

^f UNIVERSITY OF GEORGIA   (United States)

^g HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

Author keywords

Enzymes; Genetic variation; Genome wide association study; Hypertension

Indexed keywords

ANTIHYPERTENSIVE AGENT; ARGININE; CREATININE; GLUTAMINE; KYNURENINASE;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; CASE CONTROL STUDY; CELL STRAIN HEK293; CHINESE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; ENZYME ACTIVITY; ESSENTIAL HYPERTENSION; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOSITY; HETEROZYGOTE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; MISSENSE MUTATION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; WILD TYPE;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; COHORT STUDIES; FEMALE; GENETIC VARIATION; HETEROZYGOTE; HUMANS; HYDROLASES; HYPERTENSION; MALE; MIDDLE AGED; MUTATION, MISSENSE; PEDIGREE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84862910580     PISSN: 1942325X     EISSN: 19423268     Source Type: Journal    
DOI: 10.1161/CIRCGENETICS.110.959064     Document Type: Article

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