Autoreactivity against myelin basic protein in patients with chronic paraplegia

European Spine Journal

Volumn 21, Issue 5, 2012, Pages 964-970

  Zajarias Fainsod D ^a   Carrillo Ruiz, J ^a,b   Mestre, H ^a,d   Grijalva, I ^c   Madrazo, I ^c   Ibarra, A ^a,c  

^a UNIVERSIDAD ANÁHUAC   (Mexico)

^b HOSPITAL GENERAL DE MÉXICO   (Mexico)

^c INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^d HOSPITAL ÁNGELES DEL PEDREGAL   (Mexico)

Author keywords

Humoral response; IgG; Spinal cord injury; T cell response

Indexed keywords

MYELIN BASIC PROTEIN;

ADULT; ANTIBODY TITER; ARTICLE; CELLULAR IMMUNITY; CHRONIC DISEASE; CLINICAL ARTICLE; COLORIMETRY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMORAL IMMUNITY; LYMPHOCYTE PROLIFERATION; MALE; MULTIPLE SCLEROSIS; PARAPLEGIA; PRIORITY JOURNAL; SPINAL CORD INJURY; T LYMPHOCYTE;

ADULT; ANTIBODIES; CASE-CONTROL STUDIES; CELL PROLIFERATION; CHRONIC DISEASE; FEMALE; HUMANS; IMMUNITY, HUMORAL; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MYELIN BASIC PROTEINS; PARAPLEGIA; SPINAL CORD INJURIES; T-LYMPHOCYTES; TIME FACTORS;

EID: 84862901123     PISSN: 09406719     EISSN: 14320932     Source Type: Journal    
DOI: 10.1007/s00586-011-2060-7     Document Type: Article

References (18)

1. Chiu WT, Lin HC, Lam C et al (2010) Epidemiology oftraumatic spinal cord injury: comparisons between developed and devel-oping countries. Asia Pac J Public Health 22:9-18
2. Rowland JW, Hawryluk GW, Kwon B et al (2008) Current status of acute spinal cord injury pathophysiology and emerging ther-apies: promise on the horizon. Neurosurg Focus 25:E2
3. Ibarra A, Correa D, Willms K et al (2003) Effects of cyclosporin-A on immune response, tissue protection and motor function of rats subjected to spinal cord injury. Brain Res 979:165-178 (Pubitemid 36792167)
4. Popovich PG, Stokes BT, Whitacre CC (1996) Concept of autoimmunity following spinal cord injury: possible roles for T lymphocytes in the traumatized central nervous system. J Neuro-sci Res 45:349-363 (Pubitemid 26299590)
5. Kil K, Zang YCQ, Yang D et al (1999) T cell response to myelin basic protein in patients with spinal cord injury and multiple sclerosis. J Neuroimmunol 98:201-207 (Pubitemid 29317546)
6. Mizrachi Y, Ohry A, Aviel A et al (1983) Systemic humoral factors participating in the course of spinal cord injury. Para-plegia 21:287-293 (Pubitemid 13003689)
7. Hayes KC, Hull TC, Delaney GA et al (2002) Elevated serum titers of proinflammatory cytokines and CNS autoantibodies in patients with chronic spinal cord injury. J Neurotrauma 19:753-761 (Pubitemid 34761337)
8. Popovich PG, Guan Z, McGaughy V et al (2002) The neuro-pathological and behavioral consequences of intraspinal microglial/macrophage activation. J Neuropathol Exp Neurol 61:623-633 (Pubitemid 34721467)
9. Jones TB, Basso DM, Sodhi A et al (2002) Pathological CNS autoimmune disease triggered by traumatic spinal cord injury: implications for autoimmune vaccine therapy. J Neurosci 22:2690-2700 (Pubitemid 37465818)
10. Shechter R, London A, Varol C et al (2009) Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PLoS Med 6:el000113
11. Ibarra A, García E, Flores N et al (2010) Immunization with neural-derived antigens inhibits lipid peroxidation after spinal cord injury. Neurosci Lett 476:62-65
12. Ziv Y, Avidan H, Pluchino S et al (2006) Synergy between immune cells and adult neural stem/progenitor cells promotes functional recovery from spinal cord injury. PNAS 103:13174-13179 (Pubitemid 44338935)
13. Racke MK, Lovett-Racke AE (2011) Glatiramer acetate treat-ment of multiple sclerosis: an immunological perspective. J Immunol 186:1887-1890
14. Kipnis J, Nevo U, Panikashvili D et al (2003) Therapeutic vaccination for closed head injury. J Neurotrauma 20:559-569 (Pubitemid 36807900)
15. Martiñon S, Garcia E, Flores N et al (2007) Vaccination with a neural-derived peptide plus administration of glutathione improves the performance of paraplegic rats. Eur J Neurosci 26:403-412 (Pubitemid 47087600)
16. Beck KD, Nguyen HX, Galvan MD et al (2010) Quantitative analysis of cellular inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment. Brain 133:433-447
17. Cox AL, Coles AJ, Nortje J et al (2006) An investigation of auto-reactivity after head injury. J Neuroimmunol 174:180-186
18. Ibarra A, Jiménez A, Cortes C et al (2007) Influence of the intensity, level and phase of spinal cord injury on the proliferation of T cells and T-cell-dependent antibody reactions in rats. Spinal Cord 45:380-386 (Pubitemid 46701467)