Cord blood levels of IL-6, IL-8 and IL-10 may be early predictors of bronchopulmonary dysplasia in preterm newborns small for gestational age

Disease Markers

Volumn 33, Issue 1, 2012, Pages 51-60

  Rocha, Gustavo ^a   Proença, Elisa ^b   Guedes, Ana ^b   Carvalho, Carmen ^b   Areias, Augusta ^b   Ramos, João Pedro ^a   Rodrigues, Teresa ^c   Guimarães, Hercília ^a,c  

^a Hospital de so Joo   (Portugal)

^b Institute of Biomedical Sciences Abel Salazar   (Portugal)

^c University of Porto   (Portugal)

Author keywords

Bronchopulmonary dysplasia; cytokines; inflammation; preterm newborn; small for gestational age

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BLOOD SAMPLING; CHORIOAMNIONITIS; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE ASSOCIATION; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GESTATIONAL AGE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LUNG DYSPLASIA; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; NEWBORN; PREMATURITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SMALL FOR DATE INFANT; UMBILICAL CORD BLOOD; WHARTON JELLY;

EID: 84862883599     PISSN: 02780240     EISSN: 18758630     Source Type: Journal    
DOI: 10.1155/2012/925632     Document Type: Article

References (64)

1. A Bagchi, RM Viscardi, V Taciak, JE Ensor, KA McCrea, JD Hasday. Increased activity of interleukin-6 but not tumor necrosis factor-alpha in lung lavage of premature infants is associated with the development of bronchopulmonary dysplasia. Pediatr Res 1994; 36: 244-52.
2. A Garingo, L Tesoriero, R Cayabyab, M Durand, M Blahnik, S Sardesai, R Ramanathan, C Jones, K Kwong, C Li, PMinoo. Constitutive IL-10 expression by lung inflammatory cells and risk for bronchopulmonary dysplasia. Pediatr Res 2007; 61: 197-202.
3. A Jobe, E Bancalari. NICHD/NHLBI/ORD Workshop Summary - Bronchopulmonary Dysplasia. Am J Respir Crit Care Med 2001; 163: 1723-9.
4. AH Jobe. Antenatal associations with lung maturation and infection. J Perinatol 2005; 25 (suppl 2): S31-S35.
5. A Lyon. Chronic lung disease of prematurity. The role of intrauterine infection. Eur J Pediatr 2000; 159: 798-802.
6. AM Patterson, V Taciak, J Lovchic, RE Fox, AB Campbel, RM Viscardi. Ureaplasm urealyticum respiratory tract colonization is associated with an increase in IL 1-beta and tumor necrosis factor alpha relative to interleukin 6 in tracheal aspirates of preterm infants. Pediatr Infect Dis 1998; 17: 321-8.
7. AG Rijhsinghani, K Thompson, L Tygrette, SK Bathia. Inhibition of interleukin-10 during pregnancy results in neonatal growth retardation. Am J Reprod Immunol 1997; 37: 323-5.
8. BK Rinehart, DA Terrone, S Lagoo-Deenadayalan, WH Barber, EA Hale, JN Jr Martin, WA Bennett. Expression of the placental cytokines tumor necrosis factor alpha, interleukin 1beta, and interleukin 10 is increased in preeclampsia. Am J Obstet Gynecol 1999; 181: 915-20.
9. BH Su, HY Chiu, TW Lin, HC Lin. Interleukin-8 in bronchoalveolar lavage fluid of premature infants at risk of chronic lung disease. J Formos Med Assoc 2005; 104: 244-8.
10. BH Yoon, R Romero, JK Jun, KH Park, JD Park, F Ghezzi, BI Kim. Amniotic fluid cytokines (interleukin-6, tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8) and the risk for the development of bronchopulmonary dysplasia. Am J Obstet Gynecol 1997; 177: 825-30.
11. BH Yoon, R Romero, KS Kim, JS Park, SH Ki, BI Kim, JK Jun. A systemic fetal inflammatory response and the development of bronchopulmonary dysplasia. Am J Obstet Gynecol 1999; 181: 773-9.
12. BH Yoon, R Romero, CJ Kim, JK Jun, R Gomez, JH Choi, HC Syn. Amniotic fluid interleukin-6: a sensitive test for antenatal diagnosis of acute inflammatory lesions or preterm placenta and prediction of perinatal morbidity. Am J Obstet Gynecol 1995; 172: 960-70.
13. CW Choi, BI Kim, HS Kim, JD Park, JH Choi, DW Son. Increase in interleukin-6 in tracheal aspirate at birth: a predictior of subsequent bronchopulmonary dysplasia in preterm infants. Acta Paediatr 2006; 95: 38-43.
14. C Nogueira-Silva, M Santos, MJ Baptista, RS Moura, J Correia-Pinto. IL-6 is constitutively expressed during lung morphogenesis and enhances fetal lung explant branching. Pediatr Res 2006; 60: 530-6.
15. C Nogueira-Silva, RS Moura, N Esteves, S Gonzaga, J Correia-Pinto. Intrinsic catch-growth of hypoplastic fetal lungs is mediated by interleukin-6. Pediatr Pulmonol 2008; 43: 680-9.
16. CP Speer. Inflammatory mechanisms in neonatal chronic lung disease. Eur J Pediatr 1999; 158 (suppl 1): S18-S22.
17. CP Speer. New insights into the pathogenesis of pulmonary inflammation in preterm infants. Biol Neonate 2001; 79: 205-9.
18. CP Speer. Inflammation and bronchopulmonary dysplasia. Semin Neonatol 2003; 8: 29-38.
19. CP Speer. Pulmonary inflammation and bronchopulmonary dysplasia. J Perinatol 2006; 26 (suppl 1): S57-S62.
20. DY Li, J Wu, XY Zhang, ZC Fen. Expression of IL-8, SP-A and TGF-beta1 in bronchoalveolar lavage fluid of neonates with bronchopulmonary dysplasia. Zhongguo Dang Dai Er Ke Za Zhi 2010; 12: 444-6.
21. ECMcGowan, SKostadinov, KMcLean, F Gotsch, DVenturini, R Romero, AR Laptook, S Sharma. Placental IL-10 dysregulation and association with bronchopulmonary dysplasia risk. Pediatr Res 2009; 66: 455-60.
22. F Foltran, P Berchialla, S Bernasconi, E Grossi, D Gregori, ME Street. A systems biology approach: new insights into fetal growth restriction using Bayesian Networks. J Biol Regul Homeost Agents 2011; 25: 269-77.
23. FGhezzi, RGomez, RRomero, BHYoon, SS Edwin, CDavid, J Janisse, M Mazor. Elevated interleukin-8 concentrations in amniotic fluid of mothers whose neonates subsequently develop bronchopulmonary dysplasia. Eur JObstet Gynecol Reprod Biol 1998; 78: 5-10.
24. F Gotsch, R Romero, JP Kusanovic, S Mazaki-Tovi, BL Pineles, O Erez, J Espinoza, SS Hassan. The fetal inflammatory response syndrome. Clin Obstet Gynecol 2007; 50: 652-83.
25. G Amarilyo, A Oren, FB Mimouni, Y Ochsorn, V Deutsch, D Mandel. Increased cord serum inflammatory markers in smallfor-gestational-age neonates. J Perinatol 2011; 31: 30-2.
26. G Erdei, P Tóth, B Vásárhelyi. New clinical entity in perinatology: fetal inflammatory response syndrome. Orv Hetil. 2003; 144: 1515-9.
27. GI Neta, OS von Ehrenstein, LR Goldman, K Lum, R Sundaram, W Andrews, J Zhang. Umbilical cord serum cytokine levels and risks of small-for-gestational- age and preterm birth. Am J Epidemiol 2010; 171: 859-67.
28. G Kewitz, S Wudel, H Hopp, W Hopfenmuller, M Vogel, I Roots. Below median birth weight in appropriate-forgestational-age preterm infants as a risk factor for bronchopulmonary dysplasia. J Perinat Med 2008; 36: 359-64.
29. JL Bartha, R Romero-Carmona, R Comino-Delgado. Inflammatory cytokines in intrauterine growth retardation. Acta Obstet Gynecol Scand 2003; 82: 1099-102.
30. JJ Coalson, VT Winter, T Siler-Khodr, BA Yoder. Neonatal chronic lung disease in extremely immature baboons. Am J Respir Crit Care Med 1999; 160: 1333-46.
31. J Tryzmel, V Miskolci, S Castro-Alcaraz, I Vancurova, D Davidson. Interleukin-10 inhibits proinflammatory chemokine release by neutrophils of the newborn without suppression of nuclear factor kappa B. Pediatr Res 2003; 54: 382-6.
32. J Zeitlin, M El Ayoubi, PH Jarreau, ES Draper, B Blondel, W Kunzel, M Cuttini, M Kaminski, L Gortner, P Van Reempts, E Kollée, MOSAIC Research Group. J Pediatr 2010; 157: 733-9.
33. KBry, JAWhitsett, ULappalainen. IL-1beta disrupts postnatal lung morphogenesis in the mouse. Am J Respir Cell Mol Biol 2007; 36: 32-42.
34. K Bry, U Lappalainen. Pathogenesis of bronchopulmonary dysplasia: the role of interleukin 1 beta in the regulation of inflammation-mediated pulmonary retinoic acid pathways in transgenic mice. Semin Perinatol 2006; 30: 121-8.
35. K Bry, U Lappalainen, M Hallman. Cytokines and production of surfactant components. Semin Perinatol 1996, Jun; 20: 194-205.
36. K Bry, U Lappalainen, M Hallman. Intraamniotic interleukin-1 accelerates surfactant protein synthesis in fetal rabbits and improves lung stability after premature birth. J Clin Invest 1997, 99: 2992-9.
37. KM Hawker, PR Johnson, JM Hughes, JL Black. Interleukin-4 inhibits mitogen-induced proliferation of human airway smooth muscle cells in culture. Am J Physiol 1998; 275: L469-77.
38. KD Heyborne, JAMcGregor, G Henry, SSWitkin, JSAbrams. Interleukin-10 in amniotic fluid at midtrimester: immune activation and suppression in relation to fetal growth. Am J Obstet Gynecol 1994; 171: 55-9.
39. K Tullus, GW Noack, LG Burman, R Nilson, B Wretlind, A Brauner. Elevated cytokine levels in tracheobronchial aspirate fluids from ventilator treated neonateswith bronchopulmonary dysplasia. Eur J Pediatr 1996; 155: 112-6.
40. KLWatterberg, LMDemers, SMScott, SMurphy. Chorioamnionitis and early lung inflammation in infants in whom bronchopulmonary dysplasia develops. Pediatrics 1996; 97: 210-5.
41. KE Willet, BW Kramer, SG Kallapur, M Ikegami, JP Newnham, TJ Moss, PD Sly , AH Jobe. Intra-amniotic injection of IL-1 induces inflammation and maturation in fetal sheep lung. Am J Physiol Lung Cell Mol Physiol 2002; 282: L411-20.
42. K Yanamandra, P Boggs, J Loggins, RJ Baier. Interleukin-10 -1082 G/A polymorphism and risk of death or bronchopulmonary dysplasia in ventilated very low birth weight infants. Pediatr Pulmonol 2005; 39: 426-32.
43. L Gortner, I Reiss, A Hilgendorff. Bronchopulmonary dysplasia and intra-uterine growth restriction. The Lancet 2006; 368: 1.
44. L Gortner, A Hilgendorff, T Bahner, M Ebsen, I Reiss, S Rudloff. Hypoxia-induced intra-uterine growth retardation: effects on pulmonary development and surfactant protein transcription. Biol Neonate 2005; 88: 129-35.
45. M Laskwowska, K Laskwoska, B Leszczynska-Gorzelak, J Oleszczuk. Comparative analysis of the maternal and umbilical interleukin-8 levels in normal pregnancies and in pregnancies complicated by preeclampsia with intrauterine normal growth and intrauterine growth retardation. JMatern Fetal Neonatal Med 2007; 20: 527-32.
46. ME Street, CVolta, MAZiveri, IViani, S Bernasconi. Markers of insulin sensitivity in placentas and cord serum of intrauterine growth-restricted newborns. Clin Endocrinol (Oxf) 2009; 71: 394-9.
47. ME Street, P Seghini, S Fieni, MA Ziveri, C Volta, D Martorana, I Viani, D Gramellini, S Bernasconi. Changes in interleukin-6 and IGF system and their relationships in placenta and cord blood in newborns with fetal growth restriction compared with controls. Eur J Endocrinol 2006; 155: 567-74.
48. M Tosun, H Celik, B Avci, E Yavuz, T Alper, E Malatyalioglu. Maternal and umbilical serum levels of interleukin-6, interleulin-8, and tumor necrosis factor-alpha in normal pregnancies and in pregnancies complicated by preeclampsia. J Matern Fetal Neonatal Med 2010; 23: 880-6.
49. N Ambalavanan, WA Carlo, CT DÁngio, SA Mc Donald, A Das, D Schendel, P Thorsen, RD Higgins. Cytokines associated with bronchopulmonary dysplasia or death in extremely low birth weight infants. Pediatrics 2009; 123: 1132-41.
50. P von Bismarck, A Claass, C Schickor, MF Krause, S Rose-John. Altered pulmonary interleukin-6 signaling in preterm infants developing bronchopulmonary dysplasia. Exp Lung Res 2008; 34: 694-706.
51. PJ Rozance, GJ Seedorf, A Brown, G Roe, MC O'Meara, J Gien, JR Tank, SH Abman. Intrauterine growth restriction decreases pulmonary alveolar and vessel growth and causes pulmonary artery endothelial cell dysfunction in vitro fetal sheep. Am J Physiol Lung Cell Mol Physiol 2011; 301: L861-71.
52. R Mittendorf, R Covert, AG Montag, W elMasri, J Muraskas, KS Lee, PG Pryde. Special relationship between fetal inflammatory response syndrome and bronchopulmonary dysplasia in neonates. J Perinat Med 2005; 33: 428-34.
53. RA Odegard, LJ Vatten, ST Nilsen, KA Salvesen, H Vefring, R Austgulen. Umbilical cord plasma interleukin-6 and fetal growth restriction in preeclampsia: a prospective study in Norway. Obstet Gynecol 2001; 98: 289-94.
54. R Paananen, AK Husa, R Vuolteenaho, R Herva, T Kaukola, M Hallman. Blood cytokines during the perinatal period in very preterm infants: relationship of inflammatory response and bronchopulmonary dysplasia. J Pediatr 2009; 154: 39-43.
55. R Raghupathy, M Al-Azemi, F Azizieh. Intrauterine growth restriction: cytokine profiles of trophoblast antigen-stimulated maternal lymphocytes. Clin Dev Immunol 2012; 2012: 734865.
56. S Kotecha, L Wilson, A Wangoo, M Silverman, RJ Shaw. Increase in interleukin (IL)-1 beta and IL-6 in bronchoalveolar lavage fluid obtained from infants with chronic lung disease of prematurity. Pediatr Res 1996; 40: 250-6.
57. T Hata, T Kawamura, K Inada, R Fujiwaki, Y Ariyuki, K Hata, M Kitao. Interleukin-6, interleukin-8, and granulocyte elastase in newborns with fetal distress. Gynecol Obstet Invest 1996; 42: 174-7.
58. T Stallmach, G Hebisch, H Joller, P Kolditz, M Engelmann. Expression pattern of cytokines in the different compartments of the feto-maternal unit under various conditions. Reprod Fertil Dev 1995; 7: 1573-80.
59. T Stallmach, G Hebisch, HI Joller-Jemelka, P Orban, J Schwaller, MEngelmann. Cytokine production and visualized effects in the feto-maternal unit. Quantitative and topographic data on cytokines during intrauterine disease. Lab Invest 1995; 73: 384-92.
60. UK Munshi, JO Niu, MM Siddiq, LA Parton. Elevation of interleukin-8 and interleukin-6 preceds the influx of neutrophils in tracheal aspirates from preterm infants who develop bronchopulmonary dysplasia. Pediatr Pulmonol 1997; 24: 331-6.
61. V Glummoff, O Vayrinen, T Kangas, M Hallman. Degree of lung maturity determines the direction of the interleukin-1-induced effect on the expression of surfactant proteins. Am J Respir Cell Moll Biol, 2000; 22: 280-8.
62. WA Blanc. Pathology of the placenta, membranes, and umbilical cord in bacterial, fungal, and viral infections in man. In: Naeye RL, Kissane JM, eds. International Academy of Pathology Monograph. Perinatal Diseases by 14 authors. Baltimore, Williams and Willkins, 1981.
63. WA Price, BM Moats-Saats, AD Stiles. Pro and antiinflammatory cytokines regulates insulin-like growth factor binding protein production by fetal rat lung fibroblasts. Am J Respir Cell Mol Biol 2002; 26: 283-9.
64. Z Zentay, M Sharaf, M Qadir, D Drafta, D Davidson. Mechanismfor dexamethasone inhibition of neutrophil migration upon exposure to lipopolysaccharide in vitro: role of neutrophil interleukin-8 release. Pediatr Res 1999; 46: 406-10.