Jonathan E. Rhoads lecture 2011: Insulin resistance and enhanced recovery after surgery

Journal of Parenteral and Enteral Nutrition

Volumn 36, Issue 4, 2012, Pages 389-398

  Ljungqvist, Olle ^a  

^a ÖREBRO UNIVERSITY HOSPITAL   (Sweden)

Author keywords

enhanced recovery; insulin resistance; postoperative nutrition; preoperative carbohydrates; surgery

Indexed keywords

BIOSYNTHESIS; BODY MASS; CARBOHYDRATE INTAKE; CARDIOVASCULAR DISEASE; CATABOLISM; CONVALESCENCE; EPIDURAL ANESTHESIA; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HUMAN; HYPERGLYCEMIA; INFECTION; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID METABOLISM; MUSCLE METABOLISM; NONHUMAN; PERIOPERATIVE PERIOD; POSTOPERATIVE COMPLICATION; POSTOPERATIVE PERIOD; PREOPERATIVE CARE; PRIORITY JOURNAL; REVIEW; STRESS;

ANESTHESIA, EPIDURAL; DIETARY CARBOHYDRATES; FASTING; GLUCOSE; HUMANS; HYPERGLYCEMIA; INSULIN; INSULIN RESISTANCE; LENGTH OF STAY; PAIN, POSTOPERATIVE; POSTOPERATIVE CARE; POSTOPERATIVE COMPLICATIONS; PREOPERATIVE CARE; STRESS, PHYSIOLOGICAL; TREATMENT OUTCOME;

EID: 84862880593     PISSN: 01486071     EISSN: None     Source Type: Journal    
DOI: 10.1177/0148607112445580     Document Type: Review

References (70)

1. Ljungqvist O, Fearon K, Little RA Clinical Nutrition. Gibney MJ Marinos E Ljungqvist O Dowsett J, ed. Oxford, UK: Blackwell ; 2005: 312-323.
2. Ljungqvist O, Fearon K, Little RA The Human Nutrition Textbook Series. Gibney MJ Elia M Ljungqvist O Dowsett J, ed. Oxford, UK: Blackwell Science ; 2005 :
3. Brandi LS, Frediani M, Oleggini M, et al. Insulin resistance after surgery: normalization by insulin treatment. Clin Sci (Lond). 1990 ; 79 (5). 443-450
4. Thorell A, Nygren J, Ljungqvist O. Insulin resistance: a marker of surgical stress. Curr Opin Clin Nutr Metab Care. 1999 ; 2 (1). 69-78
5. Sato H, Carvalho G, Sato T, Lattermann R, Matsukawa T, Schricker T. The association of preoperative glycemic control, intraoperative insulin sensitivity, and outcomes after cardiac surgery. J Clin Endocrinol Metab. 2010 ; 95 (9). 4338-4344
6. Kehlet H. Multimodal approach to control postoperative pathophysiology and rehabilitation. Br J Anaesth. 1997 ; 78 (5). 606-617
7. Kehlet H, Mogensen T. Hospital stay of 2 days after open sigmoidectomy with a multimodal rehabilitation programme. Br J Surg. 1999 ; 86 (2). 227-230
8. Fearon KC, Ljungqvist O, Von Meyenfeldt M, et al. Enhanced recovery after surgery: a consensus review of clinical care for patients undergoing colonic resection. Clin Nutr. 2005 ; 24 (3). 466-477
9. Lassen K, Soop M, Nygren J, et al. Consensus review of optimal perioperative care in colorectal surgery: Enhanced Recovery After Surgery (ERAS) group recommendations. Arch Surg. 2009 ; 144 (10). 961-969
10. Ljungqvist O, Braga M, Fearon K Basics in Clinical Nutrition. 4 th ed.Publishing House Galén, Prague, Czech Republic; 2011:437-444. Prague, Czech Republic: Publishing House Galén ; 2011: 437-444.
11. Kehlet H, Wilmore DW. Evidence-based surgical care and the evolution of fast-track surgery. Ann Surg. 2008 ; 248 (2). 189-198
12. Varadhan KK, Neal KR, Dejong CHC, Fearon KCH, Ljungqvist O, Loboet DN. The Enhanced Recovery After Surgery (ERAS) pathway for patients undergoing major elective open colorectal surgery: a meta-analysis of randomized trials. Clin Nutr. 2010 ; 29 (4). 434-440
13. Volkert D, Saeglitz C, Gueldenzoph H, Sieber CC, Stehle P. Undiagnosed malnutrition and nutrition-related problems in geriatric patients. J Nutr Health Aging. 2010 ; 14 (5). 387-392
14. Svanfeldt M, Thorell A, Brismar K, Nygren J, Ljungqvist O. Effects of 3 days of 'postoperative' low caloric feeding with or without bed rest on insulin sensitivity in healthy subjects. Clin Nutr. 2003 ; 22 (1). 31-38
15. Biolo G, Ciocchi B, Stulle M, et al. Calorie restriction accelerates the catabolism of lean body mass during 2 wk of bed rest. Am J Clin Nutr. 2007 ; 86 (2). 366-372
16. Nygren J, Nair KS. Differential regulation of protein dynamics in splanchnic and skeletal muscle beds by insulin and amino acids in healthy human subjects. Diabetes. 2003 ; 52 (6). 1377-1385
17. Marco J, Barba R, Zapatero A, et al. Prevalence of the notification of malnutrition in the departments of internal medicine and its prognostic implications. Clin Nutr. 2011 ; 30 (4). 450-454
18. Greisen J, Juhl CB, Grfte T, et al. Acute pain induces insulin resistance in humans. Anesthesiology. 2001 ; 95 (3). 578-584
19. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 1979 ; 237 (3). E214 - E223
20. Svanfeldt M, Thorell A, Hausel J, et al. Randomized clinical trial of the effect of preoperative oral carbohydrate treatment on postoperative whole-body protein and glucose kinetics. Br J Surg. 2007 ; 94 (11). 1342-1350
21. Felländer G, Nordenström J, Tjäder I, Bolinder J, Arner P. Lipolysis during abdominal surgery. J Clin Endocrinol Metab. 1994 ; 78 (1). 150-155
22. Nygren J, Thorell A, Efendic S, Nair KS, Ljungqvist O. Site of insulin resistance after surgery: the contribution of hypocaloric nutrition and bed rest. Clin Sci (Lond). 1997 ; 93 (2). 137-146
23. Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care. 2004 ; 27 (6). 1487-1495
24. Mathur S, Plank LD, McCall JL, et al. Randomized controlled trial of preoperative oral carbohydrate treatment in major abdominal surgery. Br J Surg. 2010 ; 97 (4). 485-494
25. Ljungqvist O. Modulating postoperative insulin resistance by preoperative carbohydrate loading. Best Pract Res. 2009 ; 23: 401-409
26. Thorell A, Nygren J, Hirshman MF, et al. Surgery-induced insulin resistance in human patients: relation to glucose transport and utilization. Am J Physiol. 1999 ; 276 (4). E754 - E761
27. Wang ZG, Wang Q, Wang WJ, Qin HL. Randomized clinical trial to compare the effects of preoperative oral carbohydrate versus placebo on insulin resistance after colorectal surgery. Br J Surg. 2010 ; 97 (3). 317-327
28. Ljungqvist O, Nygren J, Thorell A, Brodin U, Efendic S. Preoperative nutrition: elective surgery in the fed or the overnight fasted state. Clin Nutr. 2001 ; 20: 167-171
29. Pierre EJ, Barrow RE, Hawkins HK, et al. Effects of insulin on wound healing. J Trauma. 1998 ; 44 (2). 342-345
30. Ljungqvist O, Nygren J, Thorell A. Modulation of post-operative insulin resistance by pre-operative carbohydrate loading. Proc Nutr Soc. 2002 ; 61 (3). 329-336
31. Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes. 2005 ; 54 (6). 1615-1625
32. Witasp A, Nordfors L, Schalling M, Nygren J, Ljungqvist O, Thorell A. Increased expression of inflammatory pathway genes in skeletal muscle during surgery. Clin Nutr. 2009 ; 28 (3). 291-298
33. Witasp A, Nordfors L, Schalling M, Nygren J, Ljungqvist O, Thorell A. Expression of inflammatory and insulin signaling genes in adipose tissue in response to elective surgery. J Clin Endocrinol Metabol. 2010 ; 95 (7). 3460-3469
34. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med. 2001 ; 345 (19). 1359-1367
35. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009 ; 360 (13). 1283-1297
36. Gustafsson UO, Thorell A, Soop M, Ljungqvist O, Nygren J. Haemoglobin A1c as a predictor of postoperative hyperglycaemia and complications after major colorectal surgery. Br J Surg. 2009 ; 96 (11). 1358-1364
37. Jackson RS, Amdur RL, White JC, Macsata RA. Hyperglycemia is associated with increased risk of morbidity and mortality after colectomy for cancer. J Am Coll Surg. 2012 ; 214 (1). 68-80
38. Kahaodiar L, McCowen K, Bistrian B. Perioperative hyperglycemia, infection or risk?. Curr Opin Clin Nutr Metab Care. 1999 ; 2: 79-82
39. Section on Legal Medicine. Edinburgh Med Surg J. 1848 ;: 69
40. Maltby JR. Fasting from midnight-the history behind the dogma. Best Pract Res Clin Anaesthesiol. 2006 ; 20 (3). 363-378
41. Maltby JR. New guidelines for preoperative fasting. Can J Anaesth. 1993 ; 40 (5). R113 - R121
42. Brady M, Kinn S, O'Rourke K, Randhawa N, Stuart P. Preoperative fasting for preventing perioperative complications in children. Cochrane Database Syst Rev. 2005 ; ( 2 ):
43. Brady M, Kinn S, Stuart P. Preoperative fasting for adults to prevent perioperative complications. Cochrane Database Syst Rev. 2003 ; ( 4 ):
44. Ljungqvist O. To fast or not to fast? Metabolic preparation for elective surgery. Scand J Nutr. 2004 ; 48 (2). 77-82
45. Frayn KN Metabolic Regulation: A Human Perspective. London: Portland Press ; 1996 :
46. Ljungqvist O, Thorell A, Gutniak M, Häggmark T, Efendic S. Glucose infusion instead of preoperative fasting reduces postoperative insulin resistance. J Am Coll Surg. 1994 ; 178 (4). 329-336
47. Nygren J, Thorell A, Jacobsson H. Preoperative gastric emptying: effects of anxiety and oral carbohydrate administration. Ann Surg. 1995 ; 222 (6). 728-734
48. Svanfeldt M, Thorell A, Hausel J, Soop M, Rooyackers O, Nygren J. Effect of "preoperative" oral carbohydrate treatment on insulin action: a randomized cross-over unblinded study in healthy subjects. Clin Nutr. 2005 ; 24: 815-821
49. Nygren J, Thorell A, Ljungqvist O. Preoperative oral carbohydrate nutrition: an update. Curr Opin Clin Nutr Metab Care. 2001 ; 4 (4). 255-259
50. Yuill KA, Richardson RA, Davidson HI, Garden OJ, Parks RW. The administration of an oral carbohydrate-containing fluid prior to major elective upper-gastrointestinal surgery preserves skeletal muscle mass postoperatively: a randomised clinical trial. Clin Nutr. 2005 ; 24 (1). 32-37
51. Crowe PJ, Dennison A, Royle GT. The effect of pre-operative glucose loading on postoperative nitrogen metabolism. Br J Surg. 1984 ; 71 (8). 635-637
52. Henriksen MG, Hessov I, Dela F, Hansen HV, Haraldsted V, Rodt SA. Effects of preoperative oral carbohydrates and peptides on postoperative endocrine response, mobilization, nutrition and muscle function in abdominal surgery. Acta Anaesthesiol Scand. 2003 ; 47 (2). 191-199
53. Melis GC, van Leeuwen PA, von Blomberg-van der Flier BM, et al. A carbohydrate-rich beverage prior to surgery prevents surgery-induced immunodepression: a randomized, controlled, clinical trial. JPEN J Parenter Enteral Nutr. 2006 ; 30 (1). 21-26
54. Uchida I, Asoh T, Shirasaka C, Tsuji H. Effect of epidural analgesia on postoperative insulin resistance as evaluated by insulin clamp technique. Br J Surg. 1988 ; 75 (6). 557-562
55. Soop M, Carlson GL, Hopkinson J, et al. Randomized clinical trial of the effects of immediate enteral nutrition on metabolic responses to major colorectal surgery in an enhanced recovery protocol. Br J Surg. 2004 ; 91: 1138-1145
56. Jrgensen H, Wetterslev J, Miniche S, Dahl JB. Epidural local anaesthetics versus opioid-based analgesic regimens on postoperative gastrointestinal paralysis, PONV and pain after abdominal surgery. Cochrane Database Syst Rev. 2000 ; ( 4 ):
57. Thorell A, Nygren J, Essén P, et al. The metabolic response to cholecystectomy: insulin resistance after open compared with laparoscopic operation. Eur J Surg. 1996 ; 162 (3). 187-191
58. Fitzgerald JE, Ahmed I. Systematic review and meta-analysis of chewing-gum therapy in the reduction of postoperative paralytic ileus following gastrointestinal surgery. World J Surg. 2009 ; 33 (12). 2557-2566
59. Lobo DN, Bostock KA, Neal KR, Perkins AC, Rowlands BJ, Allison SP. Effect of salt and water balance on recovery of gastrointestinal function after elective colonic resection: a randomised controlled trial. Lancet. 2002 ; 359 (9320). 1812-1818
60. Brandstrup B, Tnnesen H, Beier-Holgersen R, et al. Effects of intravenous fluid restriction on postoperative complications: comparison of two perioperative fluid regimens: a randomized assessor-blinded multicenter trial. Ann Surg. 2003 ; 238 (5). 641-648
61. Varadhan KK, Lobo DN. A meta-analysis of randomised controlled trials of intravenous fluid therapy in major elective open abdominal surgery: getting the balance right. Proc Nutr Soc. 2010 ; 69 (4). 488-498
62. Nygren J, Soop M, Thorell A, Efendic S, Nair KS, Ljungqvist O. Preoperative oral carbohydrate administration reduces postoperative insulin resistance. Clin Nutr. 1998 ; 17 (2). 65-71
63. Svanfeldt M, Nygren J, Ljungqvist O, Thorell A. Three days of postoperative hypocaloric feeding with or without immobilization cause marked insulin resistance in healthy volunteers. Clin Nutr. 2000 ; 19: 126
64. Levy M M. Keynote lecture, A.S.P.E.N. Nutrition Week Congress.. 2007 ;:
65. Nygren J, Hausel J, Kehlet H, et al. A comparison in five European centres of case mix, clinical management and outcomes following either conventional or fast-track perioperative care in colorectal surgery. Clin Nutr. 2005 ; 24 (3). 455-461
66. Nygren J, Soop M, Thorell A, et al. An enhanced-recovery protocol improves outcome after colorectal resection already during the first year: a single-center experience in 168 consecutive patients. Dis Colon Rectum. 2009 ; 52 (5). 978-985
67. Maessen J, Dejong CH, Hausel J, et al. A protocol is not enough to implement an enhanced recovery programme for colorectal resection. Br J Surg. 2007 ; 94 (2). 224-231
68. Jottard K, Hoff C, Maessen J, et al. Life and death of the nasogastric tube in elective colonic surgery in the Netherlands. Clin Nutr. 2009 ; 28 (1). 26-28
69. Maessen JM, Dejong CH, Kessels AG, et al. To eat or not to eat: facilitating early oral intake after elective colonic surgery in the Netherlands. Clin Nutr. 2009 ; 28 (1). 29-33
70. Gustafsson UO, Hausel J, Thorell A, Ljungqvist O, Soop M, Nygren J. Adherence to the enhanced recovery after surgery protocol and outcomes after colorectal cancer surgery. Arch Surg. 2011 ; 146 (5). 571-577