Calcium regulation of tight junction permeability

Annals of the New York Academy of Sciences

Volumn 1258, Issue 1, 2012, Pages 93-99

  Bleich, Markus ^a   Shan, Qixian ^a   Himmerkus, Nina ^a  

^a Kiel and Lungen Clinic Grosshansdorf   (Germany)

Author keywords

Calcium sensing receptor; Claudin; Ion transport; Isolated perfused tubule; Kidney

Indexed keywords

CALCIUM ION;

ARTICLE; CALCIUM ABSORPTION; CALCIUM BLOOD LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL MEMBRANE PERMEABILITY; FEEDBACK SYSTEM; HUMAN; KIDNEY CALCIFICATION; KIDNEY FUNCTION; KIDNEY TUBULE; NEPHROLITHIASIS; NONHUMAN; PROTEIN ANALYSIS; TIGHT JUNCTION;

EID: 84862878844     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2012.06539.x     Document Type: Article

References (41)

1. 2+, and Phosphate Metabolism. In Comprehensive Human Physiology - From Cellular Mechanisms To Integration. Greger, R. & U. Windhorst, Eds.: 1595-1609. Springer Verlag. Berlin Heidelberg New York
2. Riccardi, D. & E.M. Brown 2010. Physiology and pathophysiology of the calcium-sensing receptor in the kidney. Am. J. Physiol. Renal. Physiol. 298: F485-F499.
3. Fudge, N.J. & C.S. Kovacs 2004. Physiological studies in heterozygous calcium sensing receptor (CaSR) gene-ablated mice confirm that the CaSR regulates calcitonin release in vivo. BMC. Physiol. 4: 5.
4. Kos, C.H., A.C. Karaplis, J.B. Peng, et al 2003. The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone. J. Clin. Invest. 111: 1021-1028.
5. Greger, R. 1996. Renal handling of the individual solutes of glomerular filtrate. In Comprehensive Human Physiology - From Cellular Mechanisms To Integration. Greger, R. & U. Windhorst, Eds.: 1517-1544. Springer Verlag. Berlin Heidelberg New York
6. Hoenderop, J.G. & R.J. Bindels 2005. Epithelial Ca2+ and Mg2+ channels in health and disease. J. Am. Soc. Nephrol. 16: 15-26.
7. Boros, S., R.J. Bindels & J.G. Hoenderop 2009. Active Ca(2+) reabsorption in the connecting tubule. Pflugers. Arch. 458: 99-109.
8. Muto, S., M. Furuse & E. Kusano 2011. Claudins and renal salt transport. Clin. Exp. Nephrol. doi:
9. Günzel, D. & A.S. Yu 2009. Function and regulation of claudins in the thick ascending limb of Henle. Pflugers. Arch. 458: 77-88.
10. Kantham, L., S.J. Quinn, O.I. Egbuna, et al 2009. The calcium-sensing receptor (CaSR) defends against hypercalcemia independently of its regulation of parathyroid hormone secretion. Am. J. Physiol. Endocrinol. Metab. 297: E915-E923.
11. Angelow, S., R. Ahlstrom & A.S. Yu 2008. Biology of Claudins. Am. J. Physiol. Renal. Physiol. 295: F867-F876.
12. Rosenthal, R., S. Milatz, S.M. Krug, et al 2010. Claudin-2, a component of the tight junction, forms a paracellular water channel. J. Cell Sci. 123: 1913-1921.
13. Furuse, M., K. Furuse, H. Sasaki & S. Tsukita 2001. Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. J. Cell Biol. 153: 263-272.
14. Muto, S., M. Hata, J. Taniguchi, et al 2010. Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules. Proc. Natl. Acad. Sci. USA 107: 8011-8016.
15. Hou, J., A. Renigunta, M. Konrad, et al 2008. Claudin-16 and claudin-19 interact and form a cation-selective tight junction complex. J. Clin. Invest. 118: 619-628.
16. Hou, J. & D.A. Goodenough 2010. Claudin-16 and claudin-19 function in the thick ascending limb. Curr. Opin. Nephrol. Hypertens. 19: 483-488.
17. Shan, Q., N. Himmerkus, J. Hou, et al 2009. Insights into driving forces and paracellular permeability from claudin-16 knockdown mouse. Ann. N. Y. Acad. Sci. 1165: 148-151.
18. Himmerkus, N., Q. Shan, B. Goerke, et al 2008. Salt- and acid/base metabolism in claudin-16 knockdown mice - impact for the pathophysiology of FHHNC patients. Am. J. Physiol. Renal. Physiol. 295: F1641-F1647.
19. Hou, J., Q. Shan, T. Wang, et al 2007. Transgenic RNAi depletion of claudin-16 and the renal handling of magnesium. J. Biol. Chem. 282: 17114-17122.
20. Will, C., T. Breiderhoff, J. Thumfart, et al 2010. Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca2+ and Mg2+ wasting. Am. J. Physiol. Renal. Physiol. 298: F1152-F1161.
21. Greger, R. 1985. Ion transport mechanisms in thick ascending limb of Henle's loop of mammalian nephron. Physiol. Rev. 65: 760-797.
22. Greger, R. 1981. Cation selectivity of the isolated perfused cortical thick ascending limb of Henle's loop of rabbit kidney. Pflügers. Arch. 390: 30-37.
23. Günzel, D., L. Haisch, S. Pfaffenbach, et al 2009. Claudin Function in the Thick Ascending Limb of Henle's Loop. Ann. N. Y. Acad. Sci. 1165: 152-162.
24. Gong, Y., V. Renigunta, N. Himmerkus, et al 2012. Claudin-14 regulates renal Ca(++) transport in response to CaSR signalling via a novel microRNA pathway. EMBO J. doi:
25. Fromter, E. & K. Gessner 1974. Free-flow potential profile along rat kidney proximal tubule. Pflugers. Arch. 351: 69-83.
26. Larsen, E.H. & N. Mobjerg 2006. Na+ recirculation and isosmotic transport. J. Membr. Biol. 212: 1-15.
27. Dimke, H., J.G. Hoenderop & R.J. Bindels 2010. Hereditary tubular transport disorders: implications for renal handling of Ca2+ and Mg2+. Clin. Sci. (Lond.) 118: 1-18.
28. Suki, W.N., R.S. Schwettmann, F.C. Rector, Jr. & D.W. Seldin 1968. Effect of chronic mineralocorticoid administration on calcium excretion in the rat. Am. J. Physiol. 215: 71-74.
29. Pan, W., J. Borovac, Z. Spicer, et al 2011. The Epithelial Sodium-Proton Exchanger, NHE3, Is Necessary For Renal And Intestinal Calcium (Re)Absorption. Am. J. Physiol. Renal. Physiol. doi:.
30. Wright, E.M. & J.M. Diamond 1968. Effects of pH and polyvalent cations on the selective permeability of gall-bladder epithelium to monovalent ions. Biochim. Biophys. Acta. 163: 57-74.
31. Wright, E.M., P.H. Barry & J.M. Diamond 1971. The Mechanism of Cation Permeation in Rabbit Gallbladder. J. Membr. Biol. 4: 331-357.
32. Hebert, S.C. 2006. Therapeutic use of calcimimetics. Annu. Rev. Med. 57: 349-364.
33. Ward, D.T. & D. Riccardi 2002. Renal physiology of the extracellular calcium-sensing receptor. Pflugers. Arch. 445: 169-176.
34. Brown, E.M. & R.J. MacLeod 2001. Extracellular calcium sensing and extracellular calcium signaling. Physiol. Rev. 81: 239-297.
35. Ward, D.T. & D. Riccardi 2012. New concepts in calcium-sensing receptor pharmacology and signalling. Br. J. Pharmacol. 165: 35-48.
36. Di Stefano, A., M. Wittner, B. Gebler & R. Greger 1988. Increased Ca++ or mg++ concentration reduces relative tight-junction permeability to Na+ in the cortical thick ascending limb of Henle's loop of rabbit kidney. Ren. Physiol. Biochem. 11: 70-79.
37. Yu, A.S., M.H. Cheng & R.D. Coalson 2010. Calcium inhibits paracellular sodium conductance through claudin-2 by competitive binding. J. Biol. Chem. 285: 37060-37069.
38. Sayer, J.A., G. Carr & N.L. Simmons 2004. Nephrocalcinosis: molecular insights into calcium precipitation within the kidney. Clin. Sci. (Lond.) 106: 549-561.
39. Pattaragarn, A., J. Fox & U.S. Alon 2004. Effect of the calcimimetic NPS R-467 on furosemide-induced nephrocalcinosis in the young rat. Kidney Int. 65: 1684-1689.
40. Siggaard-Andersen, O., J. Thode & N. Fogh-Andersen 1983. What is "ionized calcium"? Scand. J. Clin. Lab. Invest. Suppl. 165: 11-16.
41. Greger, R. & M. Bleich 1996. Normal values for physiological parameters. In Comprehensive Human Physiology - From Cellular Mechanism to Integration. Greger, R. & U. Windhorst, Eds.: 2427-2450. Springer Verlag. Berlin Heidelberg New York