Chiral discrimination of sibutramine enantiomers by capillary electrophoresis and proton nuclear magnetic resonance spectroscopy

Archives of Pharmacal Research

Volumn 35, Issue 4, 2012, Pages 671-681

  Lee, Yong Jae ^a   Choi, Seungho ^a   Lee, Jinhoo ^a   Nguyen, Ngocvan Thi ^a   Lee, Kyungran ^a   Kang, Jong Seong ^b   Mar, Woongchon ^c   Kim, Kyeong Ho ^a  

^a Kangwon National University   (South Korea)

^b Chungnam National University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

1HNMR; Capillary electrophoresis; Chiral discrimination; Enantiomer; Methyl cyclodextrin; Sibutramine

Indexed keywords

CYCLODEXTRIN; CYCLODEXTRIN DERIVATIVE; METHYL BETA CYCLODEXTRIN; PHOSPHATE BUFFERED SALINE; SIBUTRAMINE;

ACCURACY; ARTICLE; CAPILLARY ELECTROPHORESIS; CHEMICAL INTERACTION; CHIRALITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATIONAL STUDY; DIASTEREOISOMER; DRUG DISCRIMINATION; ENANTIOMER; ENANTIOSELECTIVITY; PH; PROCESS OPTIMIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; SEPARATION TECHNIQUE; SPECTROMETER; TEMPERATURE;

BETA-CYCLODEXTRINS; CALIBRATION; CYCLOBUTANES; ELECTROPHORESIS, CAPILLARY; LIMIT OF DETECTION; LINEAR MODELS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PROTONS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; STEREOISOMERISM;

EID: 84862877705     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-0411-5     Document Type: Article

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