Oral and topical pharmacokinetic studies of a novel TRPV1 antagonist, PAC-14028 in rats and minipigs using liquid chromatography/tandem mass spectrometric method

Journal of Pharmaceutical and Biomedical Analysis

Volumn 61, Issue , 2012, Pages 8-14

  Park, Yang Hui ^a   Joo, Kyung Mi ^a   Woo, Byoung Young ^a   Son, Eui Dong ^a,b   Byun, Sang Yo ^b   Shin, Hong Ju ^a   Lee, Ki Wha ^a   Park, Young Ho ^a   Lim, Kyung Min ^a  

^a AmorePacific Corporation   (South Korea)

^b Ajou University   (South Korea)

Author keywords

LC MS MS; PAC 14028; Pharmacokinetic; Topical; Transient receptor potential vanilloid type I

Indexed keywords

[N [1 (3,5 DIFLUORO 4 METHANESULFONYLAMINO PHENYL)ETHYL] 3 (2 PROPYL 6 TRIFLUOROMETHYL PYRIDIN 3 YL)ACRYLAMIDE]; PAC 14026; PAC 14028; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1 ANTAGONIST;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MALE; MINIPIG; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY;

ACRYLAMIDES; ADMINISTRATION, ORAL; ADMINISTRATION, TOPICAL; ANIMALS; CHROMATOGRAPHY, LIQUID; MALE; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SWINE; SWINE, MINIATURE; TANDEM MASS SPECTROMETRY; TRPV CATION CHANNELS;

EID: 84856082330     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.11.011     Document Type: Article

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