Association between serum C-peptide levels and chronic microvascular complications in Korean type 2 diabetic patients

Acta Diabetologica

Volumn 49, Issue 1, 2012, Pages 83-87

  Kim, Bo Yeon ^a   Jung, Chan Hee ^a   Mok, Ji Oh ^a   Kang, Sung Koo ^a   Kim, Chul Hee ^a  

^a Soonchunhyang University College of Medicine   (South Korea)

Author keywords

C peptide; Macrovascular complications; Microvascular complications; Type 2 diabetes mellitus

Indexed keywords

C PEPTIDE; CHOLESTEROL; CREATININE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; AGE DISTRIBUTION; AGED; ALBUMINURIA; ARTICLE; ASIAN; BLOOD PRESSURE MEASUREMENT; BODY MASS; CLINICAL ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIABETIC MICROANGIOPATHY; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; DISEASE ASSOCIATION; DISEASE DURATION; DISEASE SEVERITY; FEMALE; HUMAN; KOREAN; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PREVALENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SEX DIFFERENCE; BLOOD; CHRONIC DISEASE; DIABETIC ANGIOPATHY; ETHNOLOGY; MICROVASCULATURE; MIDDLE AGED; PATHOLOGY; SOUTH KOREA; STATISTICS;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; C-PEPTIDE; CHRONIC DISEASE; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; DIABETIC NEPHROPATHIES; DIABETIC RETINOPATHY; FEMALE; HUMANS; MALE; MICROVESSELS; MIDDLE AGED; PREVALENCE; REPUBLIC OF KOREA; YOUNG ADULT;

EID: 84862866404     PISSN: 09405429     EISSN: 14325233     Source Type: Journal    
DOI: 10.1007/s00592-010-0249-6     Document Type: Article

References (33)

1. Prando R, Odetti P, Melga P, Giusti R, Ciuchi E, Cheli V (1996) Progressive deterioration of beta-cell function in nonobese type 2 diabetic subjects. Postprandial plasma C-peptide level is an indication of insulin dependency. Diabetes Metab 22:185-191
2. Haupt E, Haupt A, Herrmann R, Benecke-Timp A, Vogel H, Walter C (1999) The KID study V: the natural history of type 2 diabetes in younger patients still practising a profession. Heterogeneity of basal and reactive C-peptide levels in relation to BMI, duration of disease, age and HbA1. Exp Clin Endocrinol Diabetes 107:236-243 (Pubitemid 29322136)
3. Johansson J, Ekberg K, Shafqat J et al (2002) Molecular effects of proinsulin C-peptide. Biochem Biophys Res Commun 295:1035-1040
4. Hills CE, Brunskill NJ, Squires PE (2010) C-peptide as a therapeutic tool in diabetic nephropathy. Am J Nephrol 31:389-397
5. Mughal RS, Scragg JL, Lister P et al (2010) Cellular mechanisms by which proinsulin C-peptide prevents insulin-induced neointima formation in human saphenous vein. Diabetologia 53:1761-1771
6. Suzuki K, Watanabe K, Motegi T, Kajinuma H (1989) High prevalence of proliferative retinopathy in diabetic patients with low pancreatic B-cell capacity. Diabetes Res Clin Pract 6:45-52 (Pubitemid 19021834)
7. Steffes MW, Sibley S, Jackson M, Thomas W (2003) Beta-cell function and the development of diabetes-related complications in the Diabetes Control and Complications Trial. Diabetes Care 26:832-836 (Pubitemid 36929351)
8. Panero F, Novelli G, Zucco C et al (2009) Fasting plasma C-peptide and micro- and macrovascular complications in a large clinic-based cohort of type 1 diabetic patients. Diabetes Care 32:301-305
9. Bo S, Cavallo-Perin P, Gentile L, Repetti E, Pagano G (2000) Relationship of residual beta-cell function, metabolic control and chronic complications in type 2 diabetes mellitus. Acta Diabetol 37:125-129 (Pubitemid 32157312)
10. Sari R, Balci MK (2005) Relationship between C peptide and chronic complications in type-2 diabetes mellitus. J Natl Med Assoc 97:1113-1118 (Pubitemid 41098538)
11. Inukai T, Matsutomo R, Tayama K, Aso Y, Takemura Y (1999) Relation between the serum level of C-peptide and risk factors for coronary heart disease and diabetic microangiopathy in patients with type-2 diabetes mellitus. Exp Clin Endocrinol Diabetes 107:40-45 (Pubitemid 29082066)
12. Ahn HJ, Han KA, Kwon HR et al (2010) Small rice bowl-based meal plan versus food exchange-based meal plan for weight, glucose and lipid control in obese type 2 diabetic patients. Korean Diabetes J 34:86-94
13. Wilkinson CP, Ferris FL 3rd, Klein RE et al (2003) Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology 110:1677-1682 (Pubitemid 37025422)
14. Casellini CM, Barlow PM, Rice AL et al (2007) A 6-month, randomized, double-masked, placebo-controlled study evaluating the effects of the protein kinase C-beta inhibitor ruboxistaurin on skin microvascular blood flow and other measures of diabetic peripheral neuropathy. Diabetes Care 30:896-902 (Pubitemid 46556584)
15. Pitei DL, Watkins PJ, Stevens MJ, Edmonds ME (1994) The value of the Neurometer in assessing diabetic neuropathy by measurement of the current perception threshold. Diabet Med 11:872-876 (Pubitemid 24347673)
16. De Bacquer D, De Backer G, Kornitzer M, Blackburn H (1998) Prognostic value of ECG findings for total, cardiovascular disease, and coronary heart disease death in men and women. Heart 80:570-577 (Pubitemid 28561691)
17. De Bacquer D, De Backer G, Kornitzer M (2000) Prevalences of ECG findings in large population based samples of men and women. Heart 84:625-633
18. Samnegard B, Jacobson SH, Jaremko G, Johansson BL, Sjoquist M (2001) Effects of C-peptide on glomerular and renal size and renal function in diabetic rats. Kidney Int 60:1258-1265 (Pubitemid 32960021)
19. Djemli-Shipkolye A, Gallice P, Coste T et al (2000) The effects ex vivo and in vitro of insulin and C-peptide on Na/K adenosine triphosphatase activity in red blood cell membranes of type 1 diabetic patients. Metabolism 49:868-872 (Pubitemid 30483439)
20. Ekberg K, Brismar T, Johansson BL, Jonsson B, Lindstrom P, Wahren J (2003) Amelioration of sensory nerve dysfunction by C-Peptide in patients with type 1 diabetes. Diabetes 52:536-541 (Pubitemid 36210858)
21. Wahren J, Ekberg K, Johansson J et al (2000) Role of C-peptide in human physiology. Am J Physiol Endocrinol Metab 278:E759-E768 (Pubitemid 30366391)
22. +-ATPase activity in diabetes mellitus type I. Clin Sci (Lond) 98:283-290
23. +-ATPase alpha1-subunit in rats. Diabetes Metab Res Rev 26:193-199
24. Lee SK, Lee JO, Kim JH et al (2010) C-peptide stimulates nitrites generation via the calcium-JAK2/STAT1 pathway in murine macrophage Raw264.7 cells. Life Sci 86:863-868
25. Johansson BL, Kernell A, Sjoberg S, Wahren J (1993) Influence of combined C-peptide and insulin administration on renal function and metabolic control in diabetes type 1. J Clin Endocrinol Metab 77:976-981 (Pubitemid 23301473)
26. Johansson BL, Borg K, Fernqvist-Forbes E, Kernell A, Odergren T, Wahren J (2000) Beneficial effects of C-peptide on incipient nephropathy and neuropathy in patients with type 1 diabetes mellitus. Diabet Med 17:181-189 (Pubitemid 30212289)
27. Johansson BL, Wahren J, Pernow J (2003) C-peptide increases forearm blood flow in patients with type 1 diabetes via a nitric oxide-dependent mechanism. Am J Physiol Endocrinol Metab 285:E864-E870 (Pubitemid 37179996)
28. Walcher D, Babiak C, Poletek P et al (2006) C-Peptide induces vascular smooth muscle cell proliferation: involvement of SRC-kinase, phosphatidylinositol 3-kinase, and extracellular signalregulated kinase 1/2. Circ Res 99:1181-1187 (Pubitemid 44808654)
29. Ido Y, Vindigni A, Chang K et al (1997) Prevention of vascular and neural dysfunction in diabetic rats by C-peptide. Science 277:563-566 (Pubitemid 27369004)
30. Cotter MA, Ekberg K, Wahren J, Cameron NE (2003) Effects of proinsulin C-peptide in experimental diabetic neuropathy: vascular actions and modulation by nitric oxide synthase inhibition. Diabetes 52:1812-1817 (Pubitemid 36798068)
31. Hovorka R, Chassin L, Luzio SD, Playle R, Owens DR (1998) Pancreatic beta-cell responsiveness during meal tolerance test: model assessment in normal subjects and subjects with newly diagnosed noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 83:744-750 (Pubitemid 28496439)
32. Pasquali R, Buratti P, Biso P et al (1987) Estimation of B-cell function by the urinary excretion rate of C-peptide in diabetic patients: comparison with C-peptide response to glucagon and to a mixed meal. Diabete Metab 13:44-51 (Pubitemid 17043983)
33. Kim RS, Son YJ, Yang IM et al (1985) Postprandial 2-hr serum C-peptide concentration as a guide for insulin treatment in patients with NIDDM. Korean J Intern Med 28:779-786