Pancreatic β-cell responsiveness during meal tolerance test: Model assessment in normal subjects and subjects with newly diagnosed noninsulin- dependent diabetes mellitus

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 3, 1998, Pages 744-750

  Hovorka, Roman ^a   Chassin, Ludovic ^a   Luzio, Stephen D ^b   Playle, Rebecca ^b   Owens, David R ^b  

^a CITY UNIVERSITY   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GLUCOSE; INSULIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; POSTPRANDIAL STATE; PRIORITY JOURNAL;

ADULT; BLOOD GLUCOSE; C-PEPTIDE; DIABETES MELLITUS, TYPE 2; EATING; FEMALE; GLUCOSE; HUMANS; INSULIN; ISLETS OF LANGERHANS; MALE; METHODS; MIDDLE AGED; MODELS, BIOLOGICAL; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY;

EID: 0031732845     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.3.744     Document Type: Article

References (26)

1. DeFronzo RA, Tobin JD, Andres R. 1979 Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 237:E214-E223.
2. Toffolo G, De Grandi F, Cobelli C. 1995 Estimation of β-cell sensitivity from intravenous glucose tolerance test C-peptide data: knowledge of the kinetics avoids errors in modeling the secretion. Diabetes. 44:845-854.
3. Watanabe RM, Volund A, Roy S, Bergman RN. 1989 Prehepatic β-cell secretion during the intravenous glucose tolerance test in humans: application of a combined model of insulin and C-peptide kinetics. J Clin Endocrinol Metab. 69:790-797.
4. Piatti PM, Monti LD, Caumo A, et al. 1995 The continuous low-dose insulin and glucose-infusion test: a simplified and accurate method for the evaluation of insulin sensitivity and insulin-secretion in population studies. J Clin Endocrinol Metab. 80:34-40.
5. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. 1985 Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 28:412-419.
6. Hosker JP, Matthews DR, Rudenski AS, et al. 1985 Continuous infusion of glucose with model assessment: measurement of insulin resistance and β-cell function in man. Diabetologia. 28:401-411.
7. Eaton RP, Allen RC, Schade DS, Erickson KM, Standefer J. 1980 Prehepatic insulin production in man: kinetic analysis using peripheral connecting peptide behaviour. J Clin Endocrinol Metab. 51:520-528.
8. Hovorka R, Jones RH. 1994 How to measure insulin secretion. Diabetes Metab Rev. 10:91-117.
9. Polonsky KS, Licinio-Paixao J, Given BD, et al. 1986 Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients. J Clin Invest. 77:98-105.
10. Van Cauter E, Mestrez F, Sturis J, Polonsky KS. 1992 Estimation of insulin secretion rates from C-peptide levels: comparison of individual and standard kinetic parameters for C-peptide clearance. Diabetes. 41:368-377.
11. Heding LG. 1973 Radioimmunological determination of human C-peptide in serum. Diabetologia. 11:541-548.
12. Andersen L, Dinesen B, Jorgensen PN, Poulsen F, Roder ME. 1993 Enzyme immunoassay for intact human insulin in serum or plasma. Clin Chem. 39:578-582.
13. Carson ER, Cobelli C, Finkelstein L. 1983 The mathematical modeling of metabolic and endocrine systems. New York: Wiley and Sons.
14. Hovorka R, Young MA, Soons PA. 1996 ISEC: a program to calculate insulin secretion. Comput Methods Progr Biomed. 50:253-264.
15. Twomey S. 1965 The application of numerical filtering to the solution of integral equations encountered in indirect sensing measurements. J Franklin Inst. 279:95-109.
16. Zar JH. 1984 Biostatistical analysis, 2nd ed. Englewood Cliffs: Prentice-Hall.
17. Yang YJ, Youn JH, Bergman RN. 1987 Modified protocols improve insulin sensitivity estimation using the minimal model. Am J Physiol. 253:E595-E602.
18. Byrne MM, Sturis J, Polonsky KS. 1995 Insulin secretion and clearance during low-dose graded glucose infusion. Am J Physiol. 268:E21-E27.
19. Bech K, Damsbo P, Eldrup E, et al. 1996 β-Cell function, and glucose and lipid oxidation in graves-disease. Clin Endocrinol (Oxf). 44:59-66.
20. Christiansen E, Andersen HB, Rasmussen K, et al. 1993 Pancreatic beta-cell function and glucose metabolism in human segmental pancreas and kidney transplantation. Am J Physiol. 264:E441-E449.
21. Thorens B. 1995 Glucagon-like peptide-1 and control of insulin-secretion. Diabetes Metab. 21:311-318.
22. Nauck MA, Homberger E, Siegel EG, et al. 1986 Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses. J Clin Endocrinol Metab. 63:492-498.
23. Nauck MA, Bartels E, Orskov C, Ebert R, Creutzfeldt W. 1993 Additive insulinotropic effects of exogenous synthetic human gastric-inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose-concentrations. J Clin Endocrinol Metab. 76:912-917.
24. DeFronzo RA, Bonadonna RC, Ferrannini E. 1992 Pathogenesis of NIDDM. A balanced overview. Diabetes Care. 15:318-368.
25. Castillo MJ, Scheen AJ, Lefebvre PJ. 1995 Modified glucagon test allowing simultaneous estimation of insulin-secretion and insulin sensitivity: application to obesity, insulin-dependent diabetes-mellitus, and noninsulin-dependent diabetes-mellitus. J Clin Endocrinol Metab. 80:393-399.
26. Elahl D. 1996 In praise of the hyperglycemic clamp: a method for assessment of β-cell sensitivity and insulin-resistance. Diabetes Care. 19:278-286.