Cellular mechanisms by which proinsulin C-peptide prevents insulin-induced neointima formation in human saphenous vein

Diabetologia

Volumn 53, Issue 8, 2010, Pages 1761-1771

  Mughal, R S ^a   Scragg, J L ^a   Lister, P ^a   Warburton, P ^a   Riches, K ^a   O'Regan, D J ^a,b   Ball, S G ^a   Turner, N A ^a   Porter, K E ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b LEEDS GENERAL INFIRMARY   (United Kingdom)

Author keywords

C peptide; Endothelial cell; Human; Insulin; Migration; Neointima; Proliferation; Saphenous vein; Signalling; Smooth muscle cell; Sterol regulatory element binding transcription factor 1

Indexed keywords

C PEPTIDE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

AORTA ROOT; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CORONARY ARTERY BYPASS GRAFT; ENDOTHELIUM CELL; ENZYME INHIBITION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; INTIMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SAPHENOUS VEIN GRAFT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; ANALYSIS OF VARIANCE; CELL COUNT; CELL CULTURE; CELL MOTION; DRUG EFFECTS; HYPERPLASIA; METABOLISM; PATHOLOGY; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SAPHENOUS VEIN; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; BLOTTING, WESTERN; C-PEPTIDE; CELL COUNT; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; HYPERPLASIA; INSULIN; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SAPHENOUS VEIN; SIGNAL TRANSDUCTION; TUNICA INTIMA;

EID: 77955518344     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1736-6     Document Type: Article

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