Synthesis of a Heparan Sulfate Mimetic Library Targeting FGF and VEGF via Click Chemistry on a Monosaccharide Template

ChemMedChem

Volumn 7, Issue 7, 2012, Pages 1267-1275

  Liu, Ligong ^a,b   Li, Caiping ^a   Cochran, Siska ^a   Jimmink, Shane ^a   Ferro, Vito ^a,b  

^a Progen Pharmaceuticals Limited   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Click chemistry; Drug design; Fibroblast growth factors; Heparin mimetics; Vascular endothelial growth factor

Indexed keywords

ALCOHOL; ALKYNE; AZIDE; COPPER; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; HEPARAN SULFATE; METHYL 6 AZIDO 6 DEOXY ALPHA D MANNOPYRANOSIDE; MONOSACCHARIDE; PROPARGYL ALCOHOL; UNCLASSIFIED DRUG; VASCULOTROPIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; CLICK CHEMISTRY; CYCLOADDITION; HYDROPHOBICITY; PRIORITY JOURNAL; SULFATION; SURFACE PLASMON RESONANCE; SWERN OXIDATION; SYNTHESIS; WITTIG REACTION;

CLICK CHEMISTRY; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; HEPARITIN SULFATE; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; MONOSACCHARIDES; SMALL MOLECULE LIBRARIES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84862854758     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200151     Document Type: Article

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